A5028271549- Synthesis and biological activity
- Glycosylation and Glycoproteins Research
- Synthesis and Characterization of Heterocyclic Compounds
- T-cell and Retrovirus Studies
- Bioactive Natural Diterpenoids Research
- Synthesis and Biological Evaluation
- Cancer therapeutics and mechanisms
- Animal Genetics and Reproduction
- Bioactive Compounds and Antitumor Agents
- Berberine and alkaloids research
- Carbohydrate Chemistry and Synthesis
- Education during COVID-19 pandemic
- Evasion and Academic Success Factors
- Reproductive System and Pregnancy
- Traditional and Medicinal Uses of Annonaceae
- Mast cells and histamine
- Cell death mechanisms and regulation
- Esophageal Cancer Research and Treatment
- Plant-derived Lignans Synthesis and Bioactivity
- Insect Resistance and Genetics
- Garlic and Onion Studies
- Enzyme Production and Characterization
- Computational Drug Discovery Methods
- Science and Education Research
Universidade Federal de Campina Grande
2022
Universidade Federal da Paraíba
2011-2020
The antiproliferative activity of lectins Canavalia ensiformis (ConA) and brasiliensis (ConBr) were studied using human leukemia MOLT-4 HL-60 cell lines. It was revealed that both ConA ConBr markedly cytotoxic to cells MTT NAC assays. IC(50) values approximately 3 20 μg/mL for ConBr, respectively, cells. However, in normal peripheral blood lymphocytes, the not cytotoxic, even when tested at concentrations as high 200 μg/ml. Using comet assay, produced a rate DNA damage exceeding 80%...
Abstract Canavalia ensiformis (ConA), brasiliensis (Conbr), and Cratylia floribunda (CFL) lectins have exhibited glucose‐mannose binding specificity. We investigated the effect of fetal bovine serum (FBS) concentrations (1, 5, 10, 20%) on cytotoxic these against breast tumor cell line MCF‐7. Cell viability was examined using MTT reduction assay. When cells were grown in a medium supplemented with higher concentration (10 or 20%), all much less toxic. we used 1% FBS, it possible to achieve...
Abstract Objectives The aim of this study was to investigate the cytotoxic effect new 1,4-naphthoquinone- 1,2,3-triazoles, named C2 C8 triazole derivatives, towards human cancer cell lines. Methods on viability assessed by MTT and propidium iodide assays. C3 in K562 HL-60 cells were analyzed flow cytometry, DNA fragmentation reactive oxygen species (ROS) production. Western blot q-PCR procedures also performed. Key findings inhibited both growth a concentration-dependent manner. presented...
In this paper we present the convenient syntheses of six new guanylhydrazone and aminoguanidine tetrahydropyran derivatives 2-7. The 2, 3 4 were prepared in 100% yield, starting from corresponding aromatic ketones 8a-c hydrochloride accessed by microwave irradiation. 5, 6 7 reduction 2-4 with sodium cyanoborohydride (94% yield 7). Barbier reaction followed Prins cyclization (two steps, 63%-65% 95%-98%). Cytotoxicity studies have demonstrated effects compounds 2-7 various cancer normal cell...
The Morita-Baylis-Hillman reaction is an organocatalyzed chemical transformation that allows access to small poly-functionalized molecules and has considerable synthetic potential promising biological profiles. adducts (MBHA) are a new class of bioactive compounds highlight its potentialities the discovery cheaper efficient drugs, e.g. as anti-Leishmania chagasi Leishmania amazonensis, anti- Trypanosoma cruzi, anti-Plasmodium falciparum Plasmodium berghei, lethal against Biomphalaria...
Inflammatory response plays an important role not only in the normal physiology but also pathologies such as cancers. The Morita-Baylis-Hillman adducts (MBHA) are a novel group of synthetic molecules that have demonstrated many biological activities against some parasitic cells Plasmodium falciparum , Leishmania amazonensis and chagasi antimitotic activity sea urchin embryonic was related . However, little is known about mechanisms induced by MBHA inflammatory process its relation with...
Background: The natural products constitute an important source of antitumor and cytotoxic agents. Naphthoquinones are effectively quinones present in different plants, with demonstrated anticancer activities. A recent study conducted by our group the antileukemic potential two novel triazol-1,4- naphthoquinones derivatives, PTN (2-(4-Phenyl-1H-1,2,3-triazol-1-yl)-1,4-naphthoquinone) MPTN (2-[4- (4-Methoxyphenyl)-1H-1,2,3-triazol-1-yl]-1,4-naphthoquinone). Although, mechanisms underlying...
Despite advances in oncology research, cancer is one of the leading causes death worldwide. Thus, there a demand for development more selective and effective antitumor agents. This study showed that A398, novel podophyllotoxin analogue, was cytotoxic to HT-29, MCF-7, MOLT-4 HL-60 tumor cell lines, being less active human peripheral blood mononuclear cells normal lines FGH IEC-6. Tests using HepG2 lineage indicated its metabolites do not contribute cytotoxicity. In cells, A398 induced...
A pandemia desencadeada pelo novo coronavírus, no ano de 2020, acarretou vários impactos nos setores sociais, dentre estes a educação. Neste cenário, para que fosse possível continuidade do processo ensino-aprendizagem, diversas instituições ensino optaram por instaurar o remoto, através da adoção recursos digitais viabilizaram esta modalidade ensino. No atual período pandêmico, monitoria demonstrou-se essencial auxiliar fornecendo suporte ao docente e aos discentes disciplina. Sendo assim,...