A5042481489- Respiratory Support and Mechanisms
- Intensive Care Unit Cognitive Disorders
- Cardiac, Anesthesia and Surgical Outcomes
- Sepsis Diagnosis and Treatment
- Cardiac Arrest and Resuscitation
- Hemodynamic Monitoring and Therapy
- Long-Term Effects of COVID-19
- COVID-19 Clinical Research Studies
- Nosocomial Infections in ICU
- Traumatic Brain Injury and Neurovascular Disturbances
- Trauma and Emergency Care Studies
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Acute Kidney Injury Research
- Family and Patient Care in Intensive Care Units
- Ultrasound in Clinical Applications
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Antibiotic Resistance in Bacteria
- Pneumonia and Respiratory Infections
- COVID-19 and Mental Health
- Muscle and Compartmental Disorders
- Antibiotics Pharmacokinetics and Efficacy
- Brazilian Legal Issues
- Diabetes Treatment and Management
- Advanced X-ray and CT Imaging
- Organ Transplantation Techniques and Outcomes
Universidade Federal do Paraná
2010-2024
Hospital de Clínicas Universidade Federal do Paraná
1998-2024
Robert Bosch (Netherlands)
2024
Associação de Medicina Intensiva Brasileira
2006-2020
Centro de Estudos e Pesquisa em Saúde Coletiva
2001-2014
Hospital Israelita Albert Einstein
2010
Brazilian Research in Intensive Care Network
2010
Latin American Sepsis Institute
2010
Schiller International University
2008
Friedrich Schiller University Jena
2008
In November 2001, the Food and Drug Administration (FDA) approved drotrecogin alfa (activated) (DrotAA) for adults who had severe sepsis a high risk of death. The FDA required study to evaluate efficacy DrotAA low death.We randomly assigned adult patients with death (defined by an Acute Physiology Chronic Health Evaluation [APACHE II] score <25 or single-organ failure) receive intravenous infusion placebo (24 microg per kilogram body weight hour) 96 hours in double-blind, placebo-controlled,...
Objective: To evaluate the characteristics and outcomes of patients with cancer admitted to several intensive care units. Knowledge on requiring is mostly restricted single-center studies. Design: Prospective, multicenter, cohort study. Setting: Intensive units from 28 hospitals in Brazil. Patients: A total 717 consecutive included over a 2-mo period. Interventions: None. Measurements Main Results: There were 667 (93%) solid tumors 50 (7%) had hematologic malignancies. The main reasons for...
ABSTRACT Carbapenem-resistant Acinetobacter baumannii isolates were obtained from eight patients in two hospitals Curitiba, Brazil. The multiresistant, belonged to a single strain, and produced the OXA-23 carbapenemase. Treatment options limited, although susceptible polymyxin B vitro. strain contributed deaths of five patients.
Abstract Introduction Contemporary information on mechanical ventilation (MV) use in emerging countries is limited. Moreover, most epidemiological studies ventilatory support were carried out before significant developments, such as lung protective or broader application of non-invasive (NIV). We aimed to evaluate the clinical characteristics, outcomes and risk factors for hospital mortality failure NIV patients requiring Brazilian intensive care units (ICU). Methods In a multicenter,...
Sedation overuse is frequent and possibly associated with poor outcomes in the intensive care unit (ICU) patients. However, association of early oversedation clinical has not been thoroughly evaluated. The aim this study was to assess sedation strategies critically ill adult patients under mechanical ventilation (MV). A secondary analysis a multicenter prospective cohort conducted 45 Brazilian ICUs, including requiring ventilatory support first 48 hours ICU admissions, performed. depth...
Occurrence of hyperglycemia upon infection is associated with worse clinical outcome in COVID-19 patients. However, it still unknown whether SARS-CoV-2 directly triggers hyperglycemia. Herein, we interrogated and how causes by infecting hepatocytes increasing glucose production. We performed a retrospective cohort study including patients that were admitted at hospital suspicion COVID-19. Clinical laboratory data collected from the chart records daily blood values analyzed to test hypothesis...
Sodium-glucose cotransporter 2 (SGLT-2) inhibitors improve outcomes in patients with type diabetes, heart failure, and chronic kidney disease, but their effect on of critically ill organ failure is unknown.
Objective: Doripenem is a new carbapenem that has broad-spectrum activity against bacterial pathogens commonly responsible for nosocomial pneumonia (NP). It several advantages over currently available carbapenems and other classes of drugs used in this indication. This prospective, randomized, open-label, multicenter study was designed to establish whether doripenem noninferior piperacillin/tazobactam NP.Methods: Adults (n = 448) with signs symptoms NP, including non-ventilated patients...
Background Previous studies showed higher sepsis mortality rates in Brazil compared to other developed or developing countries. Moreover, another trial demonstrated an increased rate public hospitals private Brazil. The reasons for these findings may include delayed recognition and inadequate treatment of facilities. We designed this study evaluate the factors associated with septic patients admitted intensive care units a network institutions. Materials Methods This is retrospective...
Despite several studies designed to evaluate the efficacy of chloroquine and hydroxychloroquine in treatment coronavirus disease 2019 (COVID-19), there is still doubt about effects these drugs, especially patients with severe forms disease. This randomized, open-label, controlled, phase III trial assessed or for five days combination standard care compared alone hospitalized COVID-19. Chloroquine 450 mg BID on day 1 once daily from 2 5 400 were administered intervention group. Patients...
Ceftolozane/tazobactam is approved for treatment of hospital-acquired/ventilator-associated bacterial pneumonia (HABP/VABP) at double the dose other infection sites. Among nosocomial subtypes, ventilated HABP (vHABP) associated with lowest survival. In ASPECT-NP randomized, controlled trial, participants vHABP treated ceftolozane/tazobactam had lower 28-day all-cause mortality (ACM) than those receiving meropenem. We conducted a series post hoc analyses to explore clinical significance this...
The gold-standard method for establishing a microbiological diagnosis of COVID-19 is reverse-transcriptase polymerase chain reaction (RT-PCR). This study aimed to evaluate the accuracy, sensitivity, specificity, positive predictive value (PPV), and negative (NPV) set clinical-radiological criteria screening in patients with severe acute respiratory failure (SARF) admitted intensive care units (ICUs), using (RT-PCR) as reference standard.
Traumatic brain injury (TBI) has substantial physical, psychological, social and economic impacts, with high rates of morbidity mortality. Considering its incidence, the aim this study was to identify epidemiological clinical characteristics that predict mortality in patients hospitalized for TBI intensive care units (ICUs).A retrospective cohort carried out over 18 years old admitted an ICU a Brazilian trauma referral hospital between January 2012 August 2019. compared other traumas terms...
BackgroundGeoeconomic variations in epidemiology, the practice of ventilation, and outcome invasively ventilated intensive care unit (ICU) patients without acute respiratory distress syndrome (ARDS) remain unexplored. In this analysis we aim to address these gaps using individual patient data four large observational studies.MethodsIn pooled harmonised from ERICC, LUNG SAFE, PRoVENT, PRoVENT-iMiC prospective studies, which were conducted June, 2011, December, 2018, 534 ICUs 54 countries. We...
OBJECTIVE:To evaluate the effects of physiotherapeutic respiratory maneuvers on cerebral and cardiovascular hemodynamics blood gas variables.METHOD: A descriptive, longitudinal, prospective, nonrandomized clinical trial that included 20 critical patients with severe craniocerebral trauma who were receiving mechanical ventilation admitted to intensive care unit.Each patient was subjected vibrocompression increased manual expiratory flow (5 minutes each hemithorax), along subsequent airway...