A5052586324- Sepsis Diagnosis and Treatment
- Hemodynamic Monitoring and Therapy
- Respiratory Support and Mechanisms
- Nosocomial Infections in ICU
- Intensive Care Unit Cognitive Disorders
- Climate Change and Health Impacts
- Renal function and acid-base balance
- Cardiac Arrest and Resuscitation
- Thermal Regulation in Medicine
- Advanced Image and Video Retrieval Techniques
- Immune Response and Inflammation
- Data Management and Algorithms
- Clinical Reasoning and Diagnostic Skills
- Recommender Systems and Techniques
- Non-Invasive Vital Sign Monitoring
- Image Retrieval and Classification Techniques
- Exercise and Physiological Responses
- Machine Learning and Algorithms
- Machine Learning in Healthcare
- Machine Learning and Data Classification
- Ultrasound in Clinical Applications
- Cardiac, Anesthesia and Surgical Outcomes
- Bacterial Identification and Susceptibility Testing
- Telemedicine and Telehealth Implementation
- Maternal and Neonatal Healthcare
Universidade Estadual da Paraíba
2025
Hospital Israelita Albert Einstein
2010-2020
Norwegian University of Science and Technology
2017-2019
Universidade de São Paulo
2004-2015
Universidade Estadual de Campinas (UNICAMP)
2014
Hospital São Paulo
2009-2013
Albert Einstein College of Medicine
2006-2013
Latin American Sepsis Institute
2008-2013
Associação de Medicina Intensiva Brasileira
2011
Biology of Infection
2011
Objective: Early identification and treatment of severe sepsis can significantly reduce mortality rate. We hypothesized that a risk prediction model based on early (baseline to day 1 study) response standard care should be related 28-day survival. Design: Analysis organ dysfunction data from two placebo-controlled trials (PROWESS secretory phospholipase A2 inhibitor trials). Setting: Research laboratory. Patients: The placebo arms randomized, double-blind were combined (n = 1036). These...
The IL-1 receptor-associated kinase (IRAK-1) plays a central role in TLR2- and TLR4-induced activation of nuclear factor (NF)-kappaB, critical event the transcriptional regulation many sepsis-associated proinflammatory mediators. There are two haplotypes for IRAK-1 gene Caucasians, with variant haplotype consisting five intron single-nucleotide polymorphisms (SNPs) three exon SNPs.To examine functional significance modifying translocation NF-kappaB affecting outcomes from sepsis.One hundred...
Recomendações brasileiras de ventilação mecânica 2013. Parte
In this study, our aims were to evaluate the reactive oxygen species (ROS) and nitric oxide (NO) generation by monocytes neutrophils from septic patients correlate their levels with clinical outcomes. Forty-nine 19 healthy volunteers enrolled in study. The ROS NO production was quantified whole blood flow cytometry, constitutively, after stimulation Staphylococcus aureus Pseudomonas aeruginosa. Nitric higher compared for all conditions at baseline, than conditions. decreased day 7 that...
Background Previous studies showed higher sepsis mortality rates in Brazil compared to other developed or developing countries. Moreover, another trial demonstrated an increased rate public hospitals private Brazil. The reasons for these findings may include delayed recognition and inadequate treatment of facilities. We designed this study evaluate the factors associated with septic patients admitted intensive care units a network institutions. Materials Methods This is retrospective...
Abstract Introduction The benefits and use of low-dose corticosteroids (LDCs) in severe sepsis septic shock remain controversial. Surviving campaign guidelines suggest LDC for patients poorly responsive to fluid resuscitation vasopressor therapy. Their is suspected be wide-spread, but paucity data regarding global practice exists. purpose this study was compare baseline characteristics clinical outcomes treated or not with from the international PROGRESS (PROmoting Global Research Excellence...
Background A shift from Th1 to Th2 as well an increase in Treg CD4+T cell subsets has been reported septic patients (SP). Furthermore, these display modulation of monocyte function, with reduced production pro-inflammatory cytokines upon LPS stimulus, which resembles the phenotype alternatively activated macrophages. In this study, we evaluated percentages T cells differentiated into Th1, Th17 and subsets, percentage monocytes expressing markers monocytes/macrophages (AAM) SP....
The objective of this study is to evaluate blood glucose (BG) control efficacy and safety 3 insulin protocols in medical intensive care unit (MICU) patients.This was a multicenter randomized controlled trial involving 167 MICU patients with at least one BG measurement >or=150 mg/dL or more the following: mechanical ventilation, systemic inflammatory response syndrome, trauma, burns. interventions were computer-assisted protocol (CAIP), infusion maintaining between 100 130 mg/dL; Leuven...
Abstract Severe acute arterial hypertension can be associated with significant morbidity and mortality. After excluding a reversible etiology, choice of therapeutic intervention should based on evaluation number factors, such as age, comorbidities, other ongoing therapies. A rational pathophysiological approach then applied that integrates the effects drug blood volume, vascular tone, determinants cardiac output. Vasodilators, calcium channel blockers, beta-blocking agents all decrease...
In recent years session-based recommendation has emerged as an increasingly applicable type of recommendation. As sessions consist sequences events, this is a natural fit for Recurrent Neural Networks (RNNs). Several additions have been proposed extending such models in order to handle specific problems or data. Two extensions are 1.) modeling inter-session relations catching long term dependencies over user sessions, and 2.) temporal aspects user-item interactions. The former allows the...
BackgroundGeoeconomic variations in epidemiology, the practice of ventilation, and outcome invasively ventilated intensive care unit (ICU) patients without acute respiratory distress syndrome (ARDS) remain unexplored. In this analysis we aim to address these gaps using individual patient data four large observational studies.MethodsIn pooled harmonised from ERICC, LUNG SAFE, PRoVENT, PRoVENT-iMiC prospective studies, which were conducted June, 2011, December, 2018, 534 ICUs 54 countries. We...
To compare variations of plethysmographic wave amplitude (DeltaPpleth) and to determine the percent difference between inspiratory expiratory pulse pressure (DeltaPp) cutoff values for volume responsiveness in a homogenous population postoperative cardiac surgery patients.Intra-thoracic interfere with stroke variation. Pulse through arterial lines during mechanical ventilation have been recommended estimation fluid responsiveness. oximetry may offer non-invasive method evaluate pressure;...
Oxidative stress plays an important role in skeletal muscle damage sepsis. Aerobic exercise can decrease oxidative and enhance antioxidant defenses. Therefore, it was hypothesized that aerobic training before a sepsis stimulus could attenuate by modulating stress. Thus, the aim of this study to evaluate effects physical preconditioning on different mechanisms are involved sepsis-induced myopathy.Male Wistar rats were randomly assigned either untrained or trained group. The protocol consisted...