A5041490876- Intensive Care Unit Cognitive Disorders
- Intracranial Aneurysms: Treatment and Complications
- Traumatic Brain Injury and Neurovascular Disturbances
- Sepsis Diagnosis and Treatment
- Anesthesia and Sedative Agents
- Intracerebral and Subarachnoid Hemorrhage Research
- COVID-19 Clinical Research Studies
- Family and Patient Care in Intensive Care Units
- Neurological Disorders and Treatments
- Nosocomial Infections in ICU
- Long-Term Effects of COVID-19
- Global Maternal and Child Health
- Animal Virus Infections Studies
- Health Systems, Economic Evaluations, Quality of Life
- Cardiac Arrest and Resuscitation
- Respiratory Support and Mechanisms
- Geriatric Care and Nursing Homes
- Cerebrospinal fluid and hydrocephalus
- Neurosurgical Procedures and Complications
- Extracellular vesicles in disease
- Chromosomal and Genetic Variations
- Viral Infections and Immunology Research
- Anesthesia and Neurotoxicity Research
- Acute Ischemic Stroke Management
- Neuroinflammation and Neurodegeneration Mechanisms
Instituto Estadual do Cérebro Paulo Niemeyer
2016-2025
Fundação Oswaldo Cruz
2017-2024
D’Or Institute for Research and Education
2008-2024
University of Milano-Bicocca
2023
National Institute of Infectious Diseases
2020
FHU Neurovasc
2020
Instituto Evandro Chagas
2016-2019
Instituto Nacional do Câncer
2009-2014
Acute respiratory distress syndrome (ARDS) due to coronavirus disease 2019 (COVID-19) is associated with substantial mortality and use of health care resources. Dexamethasone might attenuate lung injury in these patients.
Importance Blood transfusions are commonly administered to patients with acute brain injury. The optimal hemoglobin transfusion threshold is uncertain in this patient population. Objective To assess the impact on neurological outcome of 2 different thresholds guide red blood cell Design, Setting, and Participants Multicenter, phase 3, parallel-group, investigator-initiated, pragmatic, open-label randomized clinical trial conducted 72 intensive care units across 22 countries. Eligible had...
Accumulating evidence into the pathogenesis of COVID-19 highlights a hypercoagulability state with high risk life-threatening thromboembolic complications. However, mechanisms and their link to hyperinflammation remain poorly understood. Here, we investigate functions platelet activation platelet-monocyte interactions in inflammatory amplification during SARS-CoV-2 infection. We used combination immunophenotyping, single-cell analysis, functional assays, pharmacological approaches gain...
To define the incidence of ventriculostomy-associated infections and their impact on mortality functional outcomes patients with aneurysmal subarachnoid hemorrhage. We prospectively included all consecutive adult hemorrhage admitted to neurological intensive care units Instituto Estadual do Cérebro Paulo Niemeyer (Rio de Janeiro, Brazil) Hospital Cristo Redentor Grande Sul, who required external ventricular drains from July 2015 December 2020. Daily clinical laboratory variables were...
Critically ill 2019 coronavirus disease (COVID-19) patients under invasive mechanical ventilation (IMV) are 10 to 40 times more likely die than the general population. Although progression from mild severe COVID-19 has been associated with hypoxia, uncontrolled inflammation, and coagulopathy, mechanisms involved in severity poorly understood.The virome of tracheal aspirates (TA) 25 IMV was assessed through unbiased RNA sequencing (RNA-seq), correlation analyses were conducted using available...
Introduction Delirium and coma are a frequent source of morbidity for ICU patients. Several factors associated with the prognosis mechanically ventilated (MV) cancer patients, but no studies evaluated delirium (acute brain dysfunction). The present study frequency impact acute dysfunction on mortality. Methods was performed at National Cancer Institute, Rio de Janeiro, Brazil. We prospectively enrolled patients >48 h diagnosis cancer. Acute assessed during first 14 days using RASS/CAM-ICU....
BackgroundGeoeconomic variations in epidemiology, the practice of ventilation, and outcome invasively ventilated intensive care unit (ICU) patients without acute respiratory distress syndrome (ARDS) remain unexplored. In this analysis we aim to address these gaps using individual patient data four large observational studies.MethodsIn pooled harmonised from ERICC, LUNG SAFE, PRoVENT, PRoVENT-iMiC prospective studies, which were conducted June, 2011, December, 2018, 534 ICUs 54 countries. We...
Cerebral infarction from delayed cerebral ischemia (DCI) is a leading cause of poor neurological outcome after aneurysmal subarachnoid hemorrhage (aSAH). We performed an international clinical practice survey to identify monitoring and management strategies for vasospasm associated with DCI in aSAH patients requiring intensive care unit admission.
To evaluate the relationships of brain iron and heme with inflammatory response systemic central nervous systems to investigate role defensive against toxicity in system.We assessed a prospective cohort patients presenting intracerebral subarachnoid hemorrhage. We assayed plasma cerebrospinal fluid samples for presence iron, heme, hemopexin, haptoglobin, enolase, S100-β cytokines first three days following hemorrhagic stroke. also analyzed dynamic changes these components within both fluids...
Background: Convalescent plasma is a potential therapeutic option for critically ill patients with coronavirus disease 19 (COVID-19), yet its efficacy remains to be determined. The aim was investigate the effects of convalescent (CP) in COVID-19. Methods: This single-center prospective observational study conducted Rio de Janeiro, Brazil, from March 17th May 30th, final follow-up on June 30th. We included 113 laboratory-confirmed COVID-19 respiratory failure. Primary outcomes were time...
Aneurysmal subarachnoid hemorrhage (SAH) is an acute cerebrovascular disease associated with high mortality and long-term functional impairment among survivors. Systemic inflammatory responses after injury nosocomial infections are frequent complications, making the management of these patients challenging. Here, we hypothesized that sepsis might be early outcomes. Our objective was to define incidence sepsis, diagnosed prospectively Sepsis-3 criteria, determine its impact on outcomes SAH....
Abstract Objectives Critically ill patients with COVID-19 may suffer from a cytokine release syndrome (CRS) characterized by remarkably high levels of interleukin 6 (IL-6). We assessed the effects tocilizumab, an IL-6 receptor antagonist, on intra-hospital mortality and development positive cultures in admitted to ICU. Design Patients COVID 19 ICU who were treated tocilizumab plus standard care enrolled compared controls. Setting severe disease Interventions Tocilizumab 400 mg IV two doses....
Delirium is an acute confusional state associated with increased mortality in the intensive care unit and long-term impaired functional recovery. Despite its elevated incidence major impact outcomes of critically ill patients, delirium remains under-diagnosed. Presently, there are validated instruments to diagnose monitor delirium, allowing detection early organ dysfunction treatment initiation. Beyond patient's non-modifiable risk factors, modifiable clinical environmental aspects that...