A5043725329- COVID-19 Clinical Research Studies
- Adipokines, Inflammation, and Metabolic Diseases
- Inflammasome and immune disorders
- Long-Term Effects of COVID-19
- Regulation of Appetite and Obesity
- Adipose Tissue and Metabolism
- Extracellular vesicles in disease
- Animal Virus Infections Studies
- Dermatological and COVID-19 studies
- Inflammatory Biomarkers in Disease Prognosis
- Complement system in diseases
- Platelet Disorders and Treatments
- Chromosomal and Genetic Variations
- Heparin-Induced Thrombocytopenia and Thrombosis
- Nerve injury and regeneration
- PARP inhibition in cancer therapy
- Atherosclerosis and Cardiovascular Diseases
- Digestive system and related health
- Obstructive Sleep Apnea Research
- Protein Kinase Regulation and GTPase Signaling
- Biotechnology and Related Fields
- Biochemical Analysis and Sensing Techniques
- Viral Infections and Immunology Research
- Blood Coagulation and Thrombosis Mechanisms
- Vibrio bacteria research studies
Fundação Oswaldo Cruz
2018-2025
Faculdades Oswaldo Cruz
2022
Infection by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been associated with leukopenia and uncontrolled inflammatory response in critically ill patients. A better comprehension of SARS-CoV-2-induced monocyte death is essential for identification therapies capable to control hyper-inflammation reduce viral replication patients 2019 disease (COVID-19). Here, we show that SARS-CoV-2 engages inflammasome triggers pyroptosis human monocytes, experimentally infected,...
Background: Leptin is an adipokine with well-known effects on the central nervous system including induction of energy expenditure and satiety. also has major relevance when activating immune cells modulating inflammatory response. In obesity, increases in white adipose tissue accumulation leptin levels are accompanied by hypothalamic resistance to leptin. Even though a leptin-rich environment, local actions regarding adipogenesis were not thoroughly investigated until now. Here we evaluate...
Accumulating evidence into the pathogenesis of COVID-19 highlights a hypercoagulability state with high risk life-threatening thromboembolic complications. However, mechanisms and their link to hyperinflammation remain poorly understood. Here, we investigate functions platelet activation platelet-monocyte interactions in inflammatory amplification during SARS-CoV-2 infection. We used combination immunophenotyping, single-cell analysis, functional assays, pharmacological approaches gain...
Coronavirus disease 2019 (COVID-19) is currently a worldwide emergency caused by Severe Acute Respiratory Syndrome 2 (SARS-CoV-2). In observational clinical studies, statins have been identified as beneficial to hospitalized patients with COVID-19. However, experimental evidence of underlying protection against SARS-CoV-2 remains elusive. Here we reported for the first-time protective effects simvastatin treatment both in vitro and vivo . We found that significantly reduced viral replication...
Genetic obesity is considered a rare disease, affecting up to 10% of patients with severe early-onset obesity. Over the past years, significant advances have been made; however, majority are misdiagnosed polygenic Thus, this study aimed identify deleterious copy number variations (CNVs) linked and explore clinical phenotypes. The sample comprised 195 adults (BMI≥35kg/m2) who developed phenotype during childhood or adolescence. We investigated CNV using Multiplex Ligation-dependent Probe...
Abstract Cardiovascular diseases and thrombotic events became major clinical problems in the combined antiretroviral therapy (cART) era. Although precise mechanisms behind these have not been fully elucidated, a persistent pro-inflammatory state plays central role. As platelets play important roles on both, thrombus formation inflammatory/immune response, we aimed at investigating platelet function HIV-infected subjects virologically controlled through cART. We evaluate parameters of...
Critically ill 2019 coronavirus disease (COVID-19) patients under invasive mechanical ventilation (IMV) are 10 to 40 times more likely die than the general population. Although progression from mild severe COVID-19 has been associated with hypoxia, uncontrolled inflammation, and coagulopathy, mechanisms involved in severity poorly understood.The virome of tracheal aspirates (TA) 25 IMV was assessed through unbiased RNA sequencing (RNA-seq), correlation analyses were conducted using available...
Obesity is a complex disease caused by combination of genetic, environmental, and epigenetic factors, associated with an increased risk chronic diseases. The leptin-melanocortin pathway integrates peripheral signals about the body's energy stores central neuronal circuit in hypothalamus. This has been extensively studied over years, as genetic variations genes related to it may play crucial role determining individual's susceptibility obesity. Therefore, we analyzed association between...
Lipid droplets (LDs), crucial organelles in lipid homeostasis and inflammation, have an understudied role antibacterial immunity. This study investigates LD accumulation triglyceride synthesis sepsis-related In E. coli-infected macrophages, formation, tied to immunometabolic reprogramming, was reduced by DGAT1 inhibition or knockdown, impairing bacterial clearance, pro-inflammatory responses (nitric oxide, PGE2, CCL2, IL-6, IFN-β), interferon-stimulated gene expression (e.g., viperin, iNOS)....
Brain-derived neurotrophic factor (BDNF) is a pro-survival in the brain that also regulates energy balance. BDNF loss-of-function point mutations are responsible for haploinsufficiency, causing severe early-onset obesity. Up to date, only few studies have sequenced this gene search rare related In study, we aimed investigate prevalence of variants cohort adults with obesity from Brazil.This study comprised 201 (BMI ≥ 35.0 kg/m2) onset during childhood- or adolescence/youth. As controls, 73...
The original version of this article unfortunately contained a mistake. authors noticed an accidental duplication Fig. 1E. correct figure can be found below. has been corrected. © 2021 Author(s).
Introduction Obesity is a multifactorial disease associated with the development of many comorbidities. This several metabolic alterations; however, it has been shown that some individuals obesity do not exhibit syndrome. Adipose tissue neutralizes detrimental effects circulating fatty acids, ectopic deposition, and inflammation, among others, through its esterification into neutral lipids are stored in adipocyte. However, when adipocyte overloaded, i.e., expansion capacity exceeded, this...
Intracerebral hemorrhage associated with vaccine-induced thrombotic thrombocytopenia
Abstract Leptin is a pleiotropic adipokine that regulates immunometabolism centrally and peripherally. Obese individuals present increased levels of leptin in the blood develop hypothalamic resistance to this adipokine. Here we investigated whether effects on periphery are maintained despite resistance. We previously reported injection induces vivo neutrophil migration peritoneal macrophage activation lean mice through TNF-α- CXCL1-dependent mechanisms. However, leukocyte biology during...
Reports of side effects vaccines against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are increasing worldwide. Capillary leak and vaccine-induced immune thrombotic thrombocytopenia very rare but life-threatening adverse events that should be identified early treated. However, isolated can indicate pseudothrombocytopenia. In certain people, ethylenediaminetetraacetic acid (EDTA) induces an in vitro platelet aggregation, resulting misleading underestimation counts. It is...
The melanocortinergic pathway orchestrates the energy homeostasis and impairments in this system often lead to an increase body weight. Rare variants melanocortin 4 receptor (MC4R) gene resulting partial or complete loss of function have been described with autosomal co-dominant inheritance. These mutations are most common cause non-syndromic monogenic obesity. In context, study aimed sequence MC4R a Brazilian cohort adults severe obesity.This included 163 unrelated probands Body Mass Index...
Abstract Infection by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been associated with leukopenia and uncontrolled inflammatory response in critically ill patients. A better comprehension of SARS-CoV-2-induced monocytes death is essential for identification therapies capable to control hyper-inflammation reduce viral replication patients COVID-19. Here, we show that SARS-CoV-2 induces inflammasome activation cell pyroptosis human monocytes, experimentally infected...
Listeriosis, caused by Listeria monocytogenes (L.m.), poses a significant public health concern as one of the most severe foodborne diseases. The pathogenesis L.m. involves critical steps such phagosome rupture and escape upon internalization. Throughout infection, influences various host processes, including lipid metabolism pathways, yet role droplets (LDs) remains unclear. Here, we reported rapid, time-dependent increase in LD formation macrophages induced biogenesis was found to be...
Este documento apresenta uma versão parcial do estudo em desenvolvimento sobre o processo de acumulação capacidades tecnológicas para atividades produção e inovação, suas fontes impactos na performance competitiva, nível empresas, no setor biotecnologia saúde humana Brasil. Considerando a alta importância estratégica dessas indústrias economia brasileira, sua capacidade inovar competir internacionalmente impacta diretamente grau extensão socioeconômico A despeito da quantidade estudos essas...