A5007461026- Platelet Disorders and Treatments
- Venous Thromboembolism Diagnosis and Management
- Sepsis Diagnosis and Treatment
- Antiplatelet Therapy and Cardiovascular Diseases
- Atrial Fibrillation Management and Outcomes
- Blood properties and coagulation
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Blood Coagulation and Thrombosis Mechanisms
- Immune Cell Function and Interaction
- Inflammatory Biomarkers in Disease Prognosis
- Acute Ischemic Stroke Management
- Heparin-Induced Thrombocytopenia and Thrombosis
- Cell Adhesion Molecules Research
- COVID-19 Clinical Research Studies
- Extracellular vesicles in disease
- Cancer-related molecular mechanisms research
- Adipokines, Inflammation, and Metabolic Diseases
- Immune Response and Inflammation
- Central Venous Catheters and Hemodialysis
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Atherosclerosis and Cardiovascular Diseases
- Acute Myocardial Infarction Research
- Blood groups and transfusion
- Complement system in diseases
- Systemic Lupus Erythematosus Research
University of Utah
2016-2025
Huntsman Cancer Institute
2025
Geriatric Research Education and Clinical Center
2017-2024
George E. Wahlen Department of VA Medical Center
2015-2024
VA Salt Lake City Healthcare System
2020-2023
General Department of Preventive Medicine
2004-2021
Centre hospitalier de l'Université Laval
2020
Centre hospitalier universitaire de Québec
2020
University of Colorado Anschutz Medical Campus
2020
Health Center
2020
Tissue factor (TF) is an essential cofactor for the activation of blood coagulation in vivo. We now report that quiescent human platelets express TF pre-mRNA and, response to activation, splice this intronic-rich message into mature mRNA. Splicing associated with increased protein expression, procoagulant activity, and accelerated formation clots. Pre-mRNA splicing controlled by Cdc2-like kinase (Clk)1, interruption Clk1 signaling prevents from accumulating activated platelets. Elevated...
Significance Immune complexes (ICs) form when antibodies encounter their antigens. ICs are present in blood multiple pathological conditions. Given the abundance of platelets and that they express a receptor for ICs, called Fcγ IIA (FcγRIIA), we examined impact mouse model. We found circulating induced systemic shock, characterized by loss consciousness, activating platelet FcγRIIA. Shock was mediated liberation serotonin, molecule better known its role brain, from granules. During were...
Abstract Thrombotic antiphospholipid syndrome (TAPS) is characterized by venous, arterial, or microvascular thrombosis. Patients with TAPS merit indefinite anticoagulation, and warfarin has historically been the standard treatment. Apixaban an oral factor Xa inhibitor anticoagulant that requires no dose adjustment monitoring. The efficacy safety of apixaban compared for patients remain unknown. This multicenter prospective randomized open-label blinded endpoint study assigned anticoagulated...
Neutrophil granulocytes, also called polymorphonuclear leukocytes (PMNs), extrude molecular lattices of decondensed chromatin studded with histones, granule enzymes, and antimicrobial peptides that are referred to as neutrophil extracellular traps (NETs). NETs capture contain bacteria, viruses, other pathogens. Nevertheless, experimental evidence indicates cause inflammatory vascular tissue damage, suggesting identifying pathways inhibit NET formation may have therapeutic implications. Here,...
Coronavirus disease 2019 (COVID-19) is associated with derangement in biomarkers of coagulation and endothelial function has been likened to the coagulopathy sepsis. However, clinical laboratory metrics suggest key differences these pathologies. We sought determine whether plasma fibrinolytic potential patients COVID-19 differ compared healthy donors critically ill Approach Results: performed comparative studies on plasmas from a single-center, cross-sectional observational study 99...
Age-related microvascular dysfunction is well characterized in rodents and humans, but little known about the properties of endothelial glycocalyx advanced age. We examined microvessels young old male C57BL6 mice (young: 6.1 ± 0.1 mo vs. old: 24.6 0.2 mo) using intravital microscopy transmission electron human participants 29 1 yr 60 2 yr) microscopy. Glycocalyx thickness mesenteric skeletal muscle was 51-54% lower compared with mice. also observed 33% sublingual microcirculation humans The...