A5098656556- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Mosquito-borne diseases and control
- Phagocytosis and Immune Regulation
- Immune cells in cancer
- Obstructive Sleep Apnea Research
- Extracellular vesicles in disease
- COVID-19 Clinical Research Studies
- Inflammatory Biomarkers in Disease Prognosis
- SARS-CoV-2 and COVID-19 Research
- Venous Thromboembolism Diagnosis and Management
- Eosinophilic Disorders and Syndromes
- Inflammasome and immune disorders
Universidade Federal do Rio de Janeiro
2024-2025
ABSTRACT Mayaro virus (MAYV) is an arthritogenic arbovirus that causes a debilitating illness can progress to chronic rheumatic disease characterized by persistent viral replication in macrophages within joint tissues. Here, we report MAYV‐infected release decondensed DNA traps (DNA extracellular traps, DETs) through mechanism driven the production of reactive oxygen species and peptidyl arginine deiminase activation, resembling classical pathogen clearance activated neutrophils. Unlike...
Neutrophils interact with Leishmania when the sandfly vector inoculates these parasites in host saliva and promastigotes-derived extracellular vesicles (EVs). It has been shown that this co-injection induces inflammation exacerbates leishmaniasis lesions. EVs are a heterogeneous group of released by cells play crucial role intercellular communication. among first to release neutrophil traps (NETs) ensnare kill promastigotes. Here, we show amazonensis induce NET formation identify molecular...
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