Israel Silva Maia
A5026650614- Respiratory Support and Mechanisms
- Intensive Care Unit Cognitive Disorders
- Sepsis Diagnosis and Treatment
- Cardiac Arrest and Resuscitation
- Nosocomial Infections in ICU
- COVID-19 Clinical Research Studies
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Long-Term Effects of COVID-19
- Hemodynamic Monitoring and Therapy
- Antibiotic Use and Resistance
- Airway Management and Intubation Techniques
- Family and Patient Care in Intensive Care Units
- Obstructive Sleep Apnea Research
- Vascular Anomalies and Treatments
- COVID-19 and Mental Health
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Neonatal Respiratory Health Research
- Healthcare professionals’ stress and burnout
- Urban Development and Societal Issues
- Thermal Regulation in Medicine
- Infection Control in Healthcare
- Climate Change and Health Impacts
- Neuroscience of respiration and sleep
- Temporomandibular Joint Disorders
- Dysphagia Assessment and Management
Universidade Federal de Santa Catarina
2017-2025
Governador Celso Ramos Hospital
2010-2025
Brazilian Research in Intensive Care Network
2020-2025
Hospital do Coração
2020-2024
Institute of Rural Management Anand
2024
Universidade Federal do Tocantins
2024
Instituto Federal do Tocantins
2024
Universidade de São Paulo
2022-2024
Instituto de Ensino e Pesquisa Santa Casa
2023
Beneficência Portuguesa de São Paulo
2020-2022
Acute respiratory distress syndrome (ARDS) due to coronavirus disease 2019 (COVID-19) is associated with substantial mortality and use of health care resources. Dexamethasone might attenuate lung injury in these patients.
Hydroxychloroquine and azithromycin have been used to treat patients with coronavirus disease 2019 (Covid-19). However, evidence on the safety efficacy of these therapies is limited.We conducted a multicenter, randomized, open-label, three-group, controlled trial involving hospitalized suspected or confirmed Covid-19 who were receiving either no supplemental oxygen maximum 4 liters per minute oxygen. Patients randomly assigned in 1:1:1 ratio receive standard care, care plus...
<h3>Importance</h3> Intravenous fluids are used for almost all intensive care unit (ICU) patients. Clinical and laboratory studies have questioned whether specific fluid types result in improved outcomes, including mortality acute kidney injury. <h3>Objective</h3> To determine the effect of a balanced solution vs saline (0.9% sodium chloride) on 90-day survival critically ill <h3>Design, Setting, Participants</h3> Double-blind, factorial, randomized clinical trial conducted at 75 ICUs...
Rationale: The effects of balanced crystalloid versus saline on clinical outcomes for ICU patients may be modified by the type fluid that received initial resuscitation and admission. Objectives: To assess whether results a randomized controlled trial could affected use before enrollment admission type. Methods: Secondary post hoc analysis BaSICS (Balanced Solution in Intensive Care Study) trial, which compared solution (Plasma-Lyte 148) with 0.9% ICU. Patients were categorized according to...
Background: Mixed trial results suggest that some ventilated patients with acute respiratory distress syndrome (ARDS) benefit from high PEEP while others may be harmed, indicating heterogeneity of treatment effect (HTE). This study applies data-driven predictive approaches to uncover HTE and re-examines previously hypothesized HTE. manuscript serves as a pre-registration planned external validation our trained models. Methods: We identified eight randomized trials, obtained individual...
Mechanical ventilation can be a life-saving intervention, but its implementation requires multidisciplinary approach, with an understanding of indications and contraindications due to the potential for complications. The management mechanical should part curricula during clinical training; however, trainees practicing professionals frequently report low confidence in managing ventilation, often seeking additional sources knowledge. Review articles, consensus statements practice guidelines...
Mechanical ventilation can be a life-saving intervention, but its implementation requires multidisciplinary approach, with an understanding of indications and contraindications due to the potential for complications. The management mechanical should part curricula during clinical training; however, trainees practicing professionals frequently report low confidence in managing ventilation, often seeking additional sources knowledge. Review articles, consensus statements practice guidelines...
Slower intravenous fluid infusion rates could reduce the formation of tissue edema and organ dysfunction in critically ill patients; however, there are no data to support different during challenges for important outcomes such as mortality.To determine effect a slower rate vs control on 90-day survival patients intensive care unit (ICU).Unblinded randomized factorial clinical trial 75 ICUs Brazil, involving 11 052 requiring at least 1 challenge with risk factor worse were from May 29, 2017,...
COVID-19) se referem a uma pneumonia viral com graus variáveis de comprometimento respiratório e até 40% dos pacientes hospitalizados, que podem desenvolver síndrome do desconforto agudo.
Rationale: Evidence from observational studies suggests that driving pressure is strongly associated with pulmonary injury and mortality, regardless of positive end-expiratory (PEEP) levels, tidal volume, or plateau pressure. Therefore, it possible targeting may improve the safety ventilation strategies for patients acute respiratory distress syndrome (ARDS). However, clinical effects a pressure-limited strategy ARDS has not been assessed in randomized controlled trials.Objectives: To...
Objectives The acute respiratory distress syndrome (ARDS) is a heterogeneous condition, and identification of subphenotypes may help in better risk stratification. Our study objective to identify ARDS using new simpler methodology readily available clinical variables. Setting This retrospective Cohort Study trials. Data from the US ARDSNet trials international ART trial. Participants 3763 patients data sets 1010 set. Primary secondary outcome measures primary was 60-day or 28-day mortality,...
Limited data is available to evaluate the burden of device associated healthcare infections (HAI) [central line bloodstream infection (CLABSI), catheter urinary tract (CAUTI), and ventilator pneumonia (VAP)] in low and-middle-income countries. Our aim investigate population attributable mortality fraction absolute difference HAI a broad critically ill patients from Brazil. Multicenter cohort study September 2019 December 2023 with prospective individual patient collection. VAP, CLABSI, CAUTI...
SummaryEarly phase dose-finding (EPDF) trials are key in the development of novel therapies, with their findings directly informing subsequent clinical phases and providing valuable insights for reverse translation. Comprehensive transparent reporting these studies is critical accurate interpretation, which may improve expedite therapeutic development. However, quality design characteristics results from EPDF often variable incomplete. The international consensus-based CONSORT-DEFINE...
A ventilação mecânica é uma intervenção que pode salvar vidas, mas sua implementação requer abordagem multidisciplinar, com a compreensão de suas indicações e contraindicações devido possíveis complicações. O manejo da deveria fazer parte dos currículos durante o estágio clínico; no entanto, os residentes profissionais em exercício frequentemente relatam pouca confiança mecânica, buscando, muitas vezes, fontes conhecimento complementares. Artigos revisão, declarações consenso diretrizes...
Early identification of patients with acute hypoxemic respiratory failure (AHRF) who are at risk failing high-flow nasal cannula (HFNC) therapy could facilitate closer monitoring, and timely adjustment/escalation treatment. We aimed to establish whether machine learning (ML) models predict HFNC outcome, early in the course treatment, greater accuracy than currently used clinical indices. developed ML trained using measurements made within first 2 h treatment from 184 AHRF (37% failures)...
The effect of conservative vs. liberal oxygen therapy on 90-day in-hospital mortality in adults with sepsis receiving unplanned invasive mechanical ventilation the intensive care unit (ICU) is uncertain.
To report data regarding COPD patients admitted to the ICU of a referral hospital for respiratory diseases, including outcomes and treatment evaluation.Study series with failure Nereu Ramos Hospital, located in city Florianópolis, Brazil, between October 2006 2007. Data related demographics, causes hospitalization, pharmacological treatment, ventilatory support, length stay, in-hospital complications, mortality, 28-day mortality were obtained from medical charts patients. Acute Physiology...