Renato Hideo Nakagawa Santos
A5059003763- Nutritional Studies and Diet
- Obesity, Physical Activity, Diet
- Cardiac Imaging and Diagnostics
- Nuts composition and effects
- Diet and metabolism studies
- COVID-19 Clinical Research Studies
- Acute Myocardial Infarction Research
- Coronary Interventions and Diagnostics
- Consumer Attitudes and Food Labeling
- Lipoproteins and Cardiovascular Health
- Nosocomial Infections in ICU
- Fatty Acid Research and Health
- Transplantation: Methods and Outcomes
- Global Public Health Policies and Epidemiology
- SARS-CoV-2 and COVID-19 Research
- Cardiac Valve Diseases and Treatments
- Renal Transplantation Outcomes and Treatments
- Acute Kidney Injury Research
- Infection Control in Healthcare
- Cardiac Arrest and Resuscitation
- Antibiotic Use and Resistance
- Pneumocystis jirovecii pneumonia detection and treatment
- Nutrition and Health in Aging
- Atrial Fibrillation Management and Outcomes
- Heart Failure Treatment and Management
Hospital do Coração
2017-2025
Universidade Estadual de Londrina
2025
i3S - Instituto de Investigação e Inovação em Saúde, Universidade do Porto
2024
Universidade de São Paulo
2018-2020
Hospital São Paulo
2018
The effects of rivaroxaban in patients with atrial fibrillation and a bioprosthetic mitral valve remain uncertain.
The effects of loading doses statins on clinical outcomes in patients with acute coronary syndrome (ACS) and planned invasive management remain uncertain.To determine if periprocedural atorvastatin decrease 30-day major adverse cardiovascular events (MACE) ACS management.Multicenter, double-blind, placebo-controlled, randomized trial conducted at 53 sites Brazil among 4191 evaluated angiography to proceed a percutaneous intervention (PCI) anatomically feasible. Enrollment occurred between...
Appropriate dietary recommendations represent a key part of secondary prevention in cardiovascular disease (CVD). We evaluated the effectiveness implementation nutritional program on quality diet, events, and death patients with established CVD.In this open-label, multicenter trial conducted 35 sites Brazil, we randomly assigned (1:1) aged 45 years or older to receive either BALANCE Program (experimental group) conventional nutrition advice (control group). The included unique education...
Loading doses of atorvastatin did not show reduction on clinical outcomes in the overall population patients with acute coronary syndrome (ACS) enrolled Statins Evaluation Coronary Procedures and Revascularization (SECURE-PCI) trial, but a potential benefit was identified who subsequently underwent percutaneous intervention (PCI).To determine whether periprocedural loading are associated decreased 30-day major adverse cardiovascular events (MACE) ACS undergoing PCI according to type timing...
Limited data is available to evaluate the burden of device associated healthcare infections (HAI) [central line bloodstream infection (CLABSI), catheter urinary tract (CAUTI), and ventilator pneumonia (VAP)] in low and-middle-income countries. Our aim investigate population attributable mortality fraction absolute difference HAI a broad critically ill patients from Brazil. Multicenter cohort study September 2019 December 2023 with prospective individual patient collection. VAP, CLABSI, CAUTI...
This study aimed to evaluate the impact of Brazilian Cardioprotective Nutrition Program (BALANCE Program) on plasma levels various apolipoproteins (A-I, A-II, B, C-II, C-III, and E) lipid biomarkers over a three-year follow-up period in individuals undergoing secondary cardiovascular prevention. exploratory analysis included 276 patients aged 45 years or older with history disease within preceding decade. Participants were randomly assigned one two groups monitored three years: BALANCE group...
international guidelines recommend that national societies establish their own database on the practice and results of CABG and, in anticipation this, BYPASS registry was introduced 2015 [2,3] .To provide a comprehensive understanding scenario cardiovascular surgery Brazil, this analysis presents clinical profile outcomes patients undergoing enrolled project, assessing data harvested from initial cohort included. METHODSThis study approved by Research Ethics Committee Universidade Federal de...
There is a lack of information from Brazil regarding therapies used and outcomes in patients with acute coronary syndrome ST elevation (STEMI).
Abstract Objectives To identify predictors of outcomes in severe twin oligo‐polyhydramnios sequence (TOPS) with or without anemia‐polycythemia (TAPS) and/or selective fetal growth restriction (SFGR) treated by laser ablation placental vessels (LAPV). Methods Analysis cases from 2011 to 2022. Variables evaluated Prenatal predictors: stages TOPS, presence TAPS SFGR; pre‐LAPV ultrasound parameters; peri‐LAPV variables. Perinatal GA at birth; birthweight; Apgar scores; transfontanellar...
Background Halofuginone (PJS-539) is an oral prolyl-tRNA synthetase inhibitor that has a potent in vitro activity against SARS-CoV-2 virus. The safety and efficacy of halofuginone Covid-19 patients not been studied. Methods We conducted phase II, randomized, double-blind, placebo-controlled, dose ranging, tolerability trial symptomatic (≤ 7 days), mostly vaccinated, non-hospitalized adults with mild to moderate Covid-19. Patients were randomized 1:1:1 ratio receive 0.5mg, 1mg or placebo...
Resumo Fundamento: A adesão à uma alimentação adequada em macronutrientes é fundamental para a prevenção secundária de doenças cardiovasculares. Objetivo: Avaliar prevalência às recomendações consumo ácidos graxos e tratamento cardiovasculares, estimar se presença determinados fatores risco cardiovascular estaria associada adesão. Métodos: Estudo transversal com os dados linha base 2358 participantes do estudo "Brazilian Cardioprotective Nutritional Program Trial". Dados alimentar, foram...
A adesão a uma alimentação saudável depende de fatores como os preços dos alimentos, sendo que alguns estudos conduzidos em países desenvolvidos apontam para um maior custo melhor qualidade nutricional. O objetivo do presente trabalho foi avaliar o direto da indivíduos adultos com doença cardiovascular no Brasil, investigando relação entre e dieta. Foram utilizados dados ensaio clínico randomizado, BALANCE Program. investigação atual é análise transversal momento inicial participantes alta...
More than 30% of major depressive disorder patients fail to respond adequate trials medications and psychotherapy. While modern neuromodulation approaches (ie, vagal nerve stimulation, deep brain stimulation) are yet prove their efficacy for such cases in large randomized controlled trials, trigeminal stimulation (TNS) has emerged as an alternative with promising effects on mood disorders.To assess efficacy, safety, tolerability, placebo effect duration continuous subcutaneous TNS (sTNS)...
Abstract Objective: To analyze the profile and outcomes of patients who underwent valve heart surgery in Brazil, using information retrieved from Brazilian Registry Cardiovascular Surgeries Adults (BYPASS Registry) database. Methods: This is a multicenter cohort study, evaluating 920 submitted to surgery. Demographics postoperative clinical were assessed compared estimate mortality risk European System for Cardiac Operative Risk Evaluation (EuroSCORE). Results: Isolated aortic replacement...
Repurposed drugs for treatment of new onset disease may be an effective therapeutic shortcut. We aimed to evaluate the efficacy repurposed antivirals compared placebo in lowering SARS-CoV2 viral load COVID-19 patients.REVOLUTIOn is a randomised, parallel, blinded, multistage, superiority and controlled randomised trial conducted 35 centres Brazil. include patients aged 18 years or older admitted hospital with laboratory-confirmed SARS-CoV-2 infection, symptoms 9 days less SpO2 94% lower at...
Readmissions after an index heart failure (HF) hospitalization are a major contemporary health care problem.
To investigate the association between body mass index (BMI), obesity, clinical outcomes, and mortality following coronary artery bypass grafting (CABG) in Brazil using a large sample with one year of follow-up from Brazilian Registry Cardiovascular Surgeries Adults (or BYPASS) database.
Abstract BACKGROUND Human morbid obesity is increasing worldwide in an alarming way. The hypothalamus known to mediate its mechanisms. Deep brain stimulation (DBS) of the ventromedial (VMH) may be alternative treat patients refractory standard medical and surgical therapies. OBJECTIVE To assess safety, identify possible side effects, optimize parameters continuous VMH-DBS. Additionally, this study aims determine if VMH-DBS will lead weight loss by causing changes body composition, basal...