A5070701813- Heart Failure Treatment and Management
- Cardiac pacing and defibrillation studies
- Cardiovascular Function and Risk Factors
- Public Health in Brazil
- Healthcare Regulation
- Cardiovascular and exercise physiology
- Protease and Inhibitor Mechanisms
- Cardiac Fibrosis and Remodeling
- Cardiac electrophysiology and arrhythmias
- Cardiac Structural Anomalies and Repair
- Cardiovascular Health and Disease Prevention
- Cerebrovascular and Carotid Artery Diseases
- Hemodynamic Monitoring and Therapy
- Mechanical Circulatory Support Devices
- Blood Pressure and Hypertension Studies
- Health Systems, Economic Evaluations, Quality of Life
- Cardiac Arrhythmias and Treatments
- Cardiovascular Disease and Adiposity
- Congenital Heart Disease Studies
- Hormonal Regulation and Hypertension
- Viral Infections and Immunology Research
- Vitamin K Research Studies
- Atrial Fibrillation Management and Outcomes
- Cardiac Imaging and Diagnostics
- Cardiac Ischemia and Reperfusion
Universidade Federal do Rio Grande do Sul
2016-2025
Hospital de Clínicas de Porto Alegre
2016-2025
Hospital Moinhos de Vento
2017-2025
Heinrich Heine University Düsseldorf
2025
Harvard University
1997-2024
Beth Israel Deaconess Medical Center
2024
British Heart Foundation
2023
University of Glasgow
2023
Direction Générale Déléguée aux Ressources
2022
Brigham and Women's Hospital
1997-2021
Matrix metalloproteinase-9 (MMP-9) is prominently overexpressed after myocardial infarction (MI). We tested the hypothesis that mice with targeted deletion of MMP9 have less left ventricular (LV) dilation experimental MI than do sibling wild-type (WT) mice. Animals survived ligation coronary artery underwent echocardiographic studies MI; all analyses were performed without knowledge mouse genotype. By day 8, knockout (KO) had significantly smaller increases in end-diastolic and end-systolic...
Background: Major surgical procedures are performed with increasing frequency in elderly persons, but the impact of age on resource use and outcomes is uncertain. Objective: To evaluate influence perioperative cardiac noncardiac complications length stay patients undergoing surgery. Design: Prospective cohort study. Setting: Urban academic medical center. Patients: Consecutive sample 4315 50 years or older who underwent nonemergent major procedures. Measurements: (cardiac noncardiac),...
Background —Extracellular matrix synthesis and degradation contribute to the morphological changes that occur after myocardial infarction (MI). Methods Results —We tested hypothesis inhibition of metalloproteinases (MMPs) attenuates left ventricular remodeling in experimental MI. Seventy-one male FVB mice survived ligation anterior coronary artery were randomized a broad-spectrum MMP inhibitor (CP-471,474) or placebo by gavage. Echocardiographic studies performed before randomization (within...
Parte 1: Diretriz Brasileira de Insuficiencia Cardiaca Cronica […] e Aguda
Abstract Background Treatment of atrial fibrillation (AF) with catheter ablation (CA) has evolved significantly. However, real-world data on long-term outcomes are limited, particularly in low- and middle-income countries. Objective This multicenter prospective cohort consecutive patients aimed to evaluate the safety efficacy first-time CA for AF Southern Brazil from 2009 2024. Methods The primary outcome was any tachyarrhythmia (ATA) recurrence. Multivariable Cox proportional hazards model...
Abstract —Although cellular adhesion molecules (CAMs) are hypothesized to play an important role in atherogenesis, the relationship between CAMs and systemic atherosclerosis is uncertain. Among 92 outpatients (48 men; mean±SD age, 65±9 years), we evaluated association of soluble vascular CAM-1 (sVCAM-1) intercellular molecule-1 (sICAM-1) with carotid intimal-medial thickness (IMT), index early atherosclerosis. All subjects underwent a 2-dimensional ultrasound examination both arteries at...
The benefits of fluid and sodium restriction in patients hospitalized with acute decompensated heart failure (ADHF) are unclear.To compare the effects a fluid-restricted (maximum intake, 800 mL/d) sodium-restricted dietary mg/d) diet (intervention group [IG]) vs no such restrictions (control [CG]) on weight loss clinical stability during 3-day period ADHF.Randomized, parallel-group trial blinded outcome assessments.Emergency room, wards, intensive care unit.Adult inpatients ADHF, systolic...
The aim of this study was to evaluate echocardiography-based indices myocardial function and markers vascular inflammation endothelial dysfunction in the early phases severe sepsis.Forty-five adult patients (67% women; age 51 ± 18 years; Acute Physiology Chronic Health Disease Classification System II score, 23 7) admitted intensive care unit up 24 hours after fulfilling criteria for sepsis or septic shock were studied. Clinical, laboratorial (endothelin 1 [ET1], cellular adhesion molecule...
1. Introdução Nos últimos anos, foram consolidados avanços expressivos no conhecimento de amiloidose cardíaca (AC), trazendo uma profunda reformulação do seu significado clínico. Além haver evidências convincentes que AC seja causa relativamente comum insuficiência com fração ejeção preservada (ICFEP), assistimos o surgimento terapias específicas modificadoras curso natural da doença, capazes prolongar a sobrevida dos pacientes acometidos. Em paralelo, relevantes progressos nas técnicas...
Treatment of atrial fibrillation (AF) with catheter ablation (CA) has evolved significantly. However, real-world data on long-term outcomes are limited, particularly in low- and middle-income countries. This multicenter prospective cohort consecutive patients aimed to evaluate the safety efficacy first-time CA for AF Southern Brazil from 2009 2024. The primary outcome was any tachyarrhythmia (ATA) recurrence. Multivariable Cox proportional hazards model assessed independent predictors Among...
Abstract —An elevated plasma concentration of the soluble intercellular adhesion molecule-1 (sICAM-1) is associated with increased risk for future coronary events. However, data exploring interrelations sICAM-1 known cardiovascular factors are sparse. We determined levels in 948 middle-aged men no prior history disease. age ( P <0.001) and were significantly smoking <0.001), hypertension <0.05), frequent alcohol consumption =0.006). Positive correlations observed between...