A5002334573- Cardiac Imaging and Diagnostics
- Cardiac pacing and defibrillation studies
- Advanced MRI Techniques and Applications
- Cardiovascular Function and Risk Factors
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Advanced X-ray and CT Imaging
- Cardiac Arrhythmias and Treatments
- Radiation Dose and Imaging
- Cardiovascular and exercise physiology
- Cardiac electrophysiology and arrhythmias
- Parathyroid Disorders and Treatments
- Acute Myocardial Infarction Research
- Cardiomyopathy and Myosin Studies
- COVID-19 and healthcare impacts
- Coronary Interventions and Diagnostics
- Ultrasound in Clinical Applications
- Cardiovascular Effects of Exercise
- Artificial Intelligence in Healthcare and Education
- Cardiac Health and Mental Health
- Transplantation: Methods and Outcomes
- Heart Rate Variability and Autonomic Control
- Sarcoidosis and Beryllium Toxicity Research
- Mesenchymal stem cell research
- Cardiac Structural Anomalies and Repair
- Pericarditis and Cardiac Tamponade
Universidade Federal Fluminense
2016-2025
Hospital Universitário Antônio Pedro
2016-2025
Hospital Pró-Cardíaco
2016-2025
Universidade Federal do Estado do Rio de Janeiro
2016-2024
Sociedade Brasileira de Pediatria
2022
Hospital Samaritano de São Paulo
2021-2022
Hospital Estadual Centra
2021
Sociedade Brasileira de Cardiologia
2020-2021
Instituto Federal de Educação, Ciência e Tecnologia de Minas Gerais
2021
Carnival Corporation (United Kingdom)
2019
Background— This study evaluated the hypothesis that transendocardial injections of autologous mononuclear bone marrow cells in patients with end-stage ischemic heart disease could safely promote neovascularization and improve perfusion myocardial contractility. Methods Results— Twenty-one were enrolled this prospective, nonrandomized, open-label (first 14 patients, treatment; last 7 control). Baseline evaluations included complete clinical laboratory evaluations, exercise stress (ramp...
Background— We recently reported the safety and feasibility of autologous bone marrow mononuclear cell (ABMMNC) injection into areas ischemic myocardium in patients with end-stage cardiomyopathy. The present study evaluated efficacy this therapy at 6- 12-month follow-up. Methods Results— Twenty follow-up (11 treated subjects; 9 controls) were enrolled prospective, nonrandomized, open-label study. Complete clinical laboratory evaluations as well exercise stress (ramp treadmill), 2-dimensional...
The ISCHEMIA trial (International Study of Comparative Health Effectiveness With Medical and Invasive Approaches) compared an initial invasive versus conservative management strategy for patients with chronic coronary disease moderate or severe ischemia, no major difference in most outcomes during a median 3.2 years. Extended follow-up mortality is ongoing.
1. Introdução Nos últimos anos, foram consolidados avanços expressivos no conhecimento de amiloidose cardíaca (AC), trazendo uma profunda reformulação do seu significado clínico. Além haver evidências convincentes que AC seja causa relativamente comum insuficiência com fração ejeção preservada (ICFEP), assistimos o surgimento terapias específicas modificadoras curso natural da doença, capazes prolongar a sobrevida dos pacientes acometidos. Em paralelo, relevantes progressos nas técnicas...
Placing the left ventricular (LV) lead in a viable segment with latest mechanical activation (vSOLA) may be associated optimal cardiac resynchronization therapy (CRT) response. We assessed role of gated SPECT myocardial perfusion imaging (gSPECT MPI) predicting clinical outcomes at 6 months patients submitted to CRT. Ten centers from 8 countries enrolled 195 consecutive patients. All underwent gSPECT MPI before and after The procedure was performed as per current guidelines, operators being...
The objective of this study was to investigate safety and feasibility autologous bone marrow mononuclear cells (BMMNC) transplantation in ST elevation myocardial infarction (STEMI), comparing anterograde intracoronary artery (ICA) delivery with retrograde vein (ICV) approach. An open labeled, randomized controlled trial 30 patients admitted STEMI used. Patients were enrolled if they 1) successfully reperfused within 24 h from symptoms onset 2) had infarct size larger than 10% the left...
1. Introduction Scientific knowledge of hypertrophic cardiomyopathy (HCM) has significantly improved in the past decades. A better understanding its pathogenesis, significant advances use imaging methods, and more common application genetic analysis, addition to a characterization natural history this myocardial disease, have profoundly reformulated clinical prognostic significance. Conversely, these processes were accompanied by development new medications addressing molecular mechanisms...
Background— Cell-based therapies for treatment of ischemic heart disease are currently under investigation. We previously reported the results a phase I trial transendocardial injection autologous bone marrow mononuclear (ABMM) cells in patients with end-stage disease. The current report focuses on postmortem cardiac findings from one treated patients, who died 11 months after cell therapy. Methods and Results— Anatomicopathologic, morphometric, immunocytochemical anterolateral ventricular...
Objective: To evaluate the feasibility of monitoring autologous mononuclear bone marrow (ABMMN) cells implanted into brain after acute ischemic stroke by technique labeling with Tc-99m-HMPAO. Case Report: A 37-year-old man presented aphasia, right-side hypoesthesia, and right homonymous hemianopsia an left middle cerebral artery. He was included in cell-based therapy research protocol about safety intra-arterial cell transplantation for stroke. Nine days he received 3.0 × 107 ABMMN delivered...
Clinical parameters measured from gated single-photon emission computed tomography myocardial perfusion imaging (SPECT MPI) have value in predicting cardiac resynchronization therapy (CRT) patient outcomes, but still show limitations. The purpose of this study is to combine clinical variables, features electrocardiogram (ECG), and assessment function with polar maps SPECT MPI through deep learning (DL) predict CRT response. A total 218 patients who underwent rest-gated were enrolled study....
Os recentes avanços ao nível de hardware e a crescente exigência personalização dos cuidados associados às necessidades urgentes criação valor para os pacientes contribuíram que Inteligência Artificial (IA) promovesse uma mudança significativa paradigma nas mais diversas áreas do conhecimento médico, em particular Cardiologia, por sua capacidade apoiar tomada decisões melhorar o desempenho diagnóstico prognóstico. Nesse contexto, presente trabalho faz revisão não-sistemática principais...
Background . Glomerular filtration rate (GFR) is usually estimated from equations using serum creatinine (sCr), with adjustment for gender, age, and race (black or nonblack). The Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) the preferred equation adults, but it was validated United States population. We intended to evaluate if race-ethnicity proposed sCr-based CKD-EPI appropriate Brazilian Methods CKD outpatients had blood samples collected determination of sCr cystatin C...
1. Introdução O conhecimento médico científico sobre a cardiomiopatia hipertrófica (CMH) recebeu grande avanço nas últimas décadas. melhor entendimento da sua patogênese, os avanços expressivos no emprego dos métodos de imagem e aplicação mais corriqueira análise genética, além caracterização história natural dessa doença miocárdica, trouxeram uma profunda reformulação do seu significado clínico prognóstico. Por outro lado, esses progressos foram acompanhados desenvolvimento novas drogas...
Resumo Fundamento A patisirana reduziu rapidamente a transtirretina e preservou capacidade funcional em pacientes com amiloidose por cardiomiopatia (ATTR-CM) no estudo Fase 3 APOLLO-B (NCT03997383). Objetivos Avaliar eficácia segurança da (análise post hoc) na subpopulação brasileira do APOLLO-B. Métodos Pacientes foram randomizados 1:1 para 0,3 mg/kg ou placebo uma vez cada semanas 12 meses. O desfecho primário foi alteração relação ao período basal (ARPB) (teste de caminhada 6 minutos...