A5051674313- Cardiac Imaging and Diagnostics
- Coronary Interventions and Diagnostics
- Acute Myocardial Infarction Research
- Lipoproteins and Cardiovascular Health
- Health Systems, Economic Evaluations, Quality of Life
- Cardiovascular Function and Risk Factors
- Cardiac, Anesthesia and Surgical Outcomes
- Cardiac Health and Mental Health
- Cardiovascular Disease and Adiposity
- Blood Pressure and Hypertension Studies
- Heart Failure Treatment and Management
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Antiplatelet Therapy and Cardiovascular Diseases
- Cardiovascular Health and Risk Factors
- Diverticular Disease and Complications
- Anorectal Disease Treatments and Outcomes
- Pharmaceutical Economics and Policy
- Colorectal Cancer Surgical Treatments
- Cardiovascular and exercise physiology
- Radiation Dose and Imaging
- Advanced X-ray and CT Imaging
- Cerebrovascular and Carotid Artery Diseases
- Medication Adherence and Compliance
- Peripheral Artery Disease Management
- Advanced MRI Techniques and Applications
Stanford University
2016-2025
Cardiovascular Institute of the South
2016-2024
New York University
2011-2024
Icahn School of Medicine at Mount Sinai
2024
University of California, Irvine
2024
National Heart Lung and Blood Institute
2024
The University of Texas Health Science Center at Houston
2024
Stanford Medicine
2015-2024
Palo Alto University
2024
University of Louisville Hospital
2024
In patients with stable coronary artery disease, it remains unclear whether an initial management strategy of percutaneous intervention (PCI) intensive pharmacologic therapy and lifestyle (optimal medical therapy) is superior to optimal alone in reducing the risk cardiovascular events.We conducted a randomized trial involving 2287 who had objective evidence myocardial ischemia significant disease at 50 U.S. Canadian centers. Between 1999 2004, we assigned 1149 undergo PCI (PCI group) 1138...
Among patients with stable coronary disease and moderate or severe ischemia, whether clinical outcomes are better in those who receive an invasive intervention plus medical therapy than alone is uncertain.
Background— Extent and severity of myocardial ischemia are determinants risk for patients with coronary artery disease, reduction is an important therapeutic goal. The Clinical Outcomes Utilizing Revascularization Aggressive Drug Evaluation (COURAGE) nuclear substudy compared the effectiveness percutaneous intervention (PCI) added to optimal medical therapy (OMT) use perfusion single photon emission computed tomography (MPS). Methods Results— Of 2287 COURAGE patients, 314 were enrolled in...
BACKGROUND Recent clinical trials have shown that modification of plasma lipoprotein concentrations can favorably alter progression coronary atherosclerosis, but no data exist on the effects a comprehensive program risk reduction involving both changes in lifestyle and medications. This study tested hypothesis intensive multiple factor over 4 years would significantly reduce rate atherosclerosis arteries men women compared with subjects randomly assigned to usual care their physician....
It has not been clearly established whether percutaneous coronary intervention (PCI) can provide an incremental benefit in quality of life over that provided by optimal medical therapy among patients with chronic artery disease.We randomly assigned 2287 stable disease to PCI plus or alone. We assessed angina-specific health status (with the use Seattle Angina Questionnaire) and overall physical mental function RAND 36-item survey [RAND-36]).At baseline, 22% were free angina. At 3 months, 53%...
Clinical trials that have assessed the effect of revascularization in patients with stable coronary disease routinely excluded those advanced chronic kidney disease.
In the ISCHEMIA trial, an invasive strategy with angiographic assessment and revascularization did not reduce clinical events among patients stable ischemic heart disease moderate or severe ischemia. A secondary objective of trial was to assess angina-related health status these patients.
<h3>Importance</h3> Statins decrease mortality in those with atherosclerotic cardiovascular disease (ASCVD), but statin adherence remains suboptimal. <h3>Objective</h3> To determine the association between and patients ASCVD who have stable prescriptions. <h3>Design, Setting, Participants</h3> This retrospective cohort analysis included were ages 21 85 years had 1 or more<i>International Classification of Diseases, Ninth Revision, Clinical Modification</i>codes for on 2 more dates previous...
Percutaneous coronary intervention (PCI) relieves angina in patients with stable ischemic heart disease, but clinical trials have not shown that it improves survival. Between June 1999 and January 2004, we randomly assigned 2287 disease to an initial management strategy of optimal medical therapy alone (medical-therapy group) or plus PCI (PCI did find a significant difference the rate survival during median follow-up 4.6 years. We now report among who were followed for up 15 years.We...
The ISCHEMIA trial (International Study of Comparative Health Effectiveness With Medical and Invasive Approaches) postulated that patients with stable coronary artery disease (CAD) moderate or severe ischemia would benefit from revascularization. We investigated the relationship between severity CAD outcomes, overall by management strategy. In total, 5179 were randomized to an initial invasive conservative Blinded, core laboratory-interpreted computed tomographic angiography was used assess...
Indocyanine green fluoroscopy has been shown to improve anastomotic leak rates in early phase trials.We hypothesized that the use of ensure perfusion may decrease after low anterior resection.We performed a 1:1 randomized controlled parallel study. Recruitment 450 1000 patients was planned over 2 years.This multicenter trial.Included were those undergoing resection defined as anastomosis within 10 cm anal verge.Patients underwent standard evaluation tissue versus conjunction with using...
Coronary artery disease (CAD), the most common manifestation of cardiovascular disease, remains cause mortality in United States. Risk assessment is key for primary prevention coronary events and calcium (CAC) scoring using computed tomography (CT) one such non-invasive tool. Despite proven clinical value CAC, current practice implementation CAC has limitations as lack insurance coverage test, need capital-intensive CT machines, specialized imaging protocols, accredited 3D labs analysis...
The ISCHEMIA trial (International Study of Comparative Health Effectiveness With Medical and Invasive Approaches) compared an initial invasive versus conservative management strategy for patients with chronic coronary disease moderate or severe ischemia, no major difference in most outcomes during a median 3.2 years. Extended follow-up mortality is ongoing.
Background: Coronary artery calcium (CAC) can be identified on nongated chest computed tomography (CT) scans, but this finding is not consistently incorporated into care. A deep learning algorithm enables opportunistic CAC screening of CT scans. Our objective was to evaluate the effect notifying clinicians and patients incidental statin initiation. Methods: NOTIFY-1 (Incidental Calcification Quality Improvement Project) a randomized quality improvement project in Stanford Health Care System....
Abstract Background and Aims The aim of this study was to determine the prognostic value coronary computed tomography angiography (CCTA)–derived atherosclerotic plaque analysis in ISCHEMIA. Methods Atherosclerosis imaging quantitative (AI-QCT) performed on all available baseline CCTAs quantify volume, composition, distribution. Multivariable Cox regression used examine association between risk factors (age, sex, smoking, diabetes, hypertension, ejection fraction, prior disease, estimated...