A5101570626- Liver Disease Diagnosis and Treatment
- Cardiac Imaging and Diagnostics
- Hepatocellular Carcinoma Treatment and Prognosis
- Hepatitis C virus research
- Liver Disease and Transplantation
- Alzheimer's disease research and treatments
- Hepatitis B Virus Studies
- Coronary Interventions and Diagnostics
- Medical Imaging Techniques and Applications
- Lipoproteins and Cardiovascular Health
- Cholinesterase and Neurodegenerative Diseases
- Acute Myocardial Infarction Research
- Atherosclerosis and Cardiovascular Diseases
- Immune Cell Function and Interaction
- Gastric Cancer Management and Outcomes
- Spine and Intervertebral Disc Pathology
- Pelvic and Acetabular Injuries
- Hematopoietic Stem Cell Transplantation
- Cardiovascular Disease and Adiposity
- Neuroscience and Neuropharmacology Research
- Cancer, Hypoxia, and Metabolism
- Radiomics and Machine Learning in Medical Imaging
- Lung Cancer Diagnosis and Treatment
- Cancer Immunotherapy and Biomarkers
- Ultrasound and Hyperthermia Applications
Tokyo Medical University
2020-2025
Kumamoto City Hospital
2021-2025
Kasugai Municipal Hospital
2023-2025
University of Tsukuba
2021-2025
Fukushima Medical University
2013-2025
Research Organization of Information and Systems
2024-2025
Fuji Electric (Japan)
2024
Fujita Health University
2024
Nihon University
2002-2021
Iwate Prefectural Central Hospital
2016-2021
Aliment Pharmacol Ther 2010; 32: 1080–1090 Summary Background Hepatic encephalopathy has a negative effect on patient health‐related quality of life (HRQOL). Zinc supplementation been effective with regard to altered nitrogen metabolism. Aim To investigate the effectiveness oral zinc hepatic and HRQOL. Methods Seventy‐nine cirrhotic patients were randomized receive 225 mg polaprezinc in addition standard therapies protein‐restricted diet including branched‐chain amino acid lactulose, or...
The pathogenesis of sepsis-induced acute lung injury (ALI)/acute respiratory distress syndrome (ARDS) has not yet been fully elucidated. Growth arrest-specific 6 (Gas6) marked effects on hemostasis and reduces inflammation through its interaction with receptor tyrosine kinases the TAM family: Tyro3, Axl, Mer. Here, we found that plasma concentrations Gas6 soluble Mer were greater in patients severe sepsis or septic ALI/ARDS compared those normal healthy donors. To determine whether Gas6-Mer...
Despite the diversity of thermal ablations, such as radiofrequency ablation (RFA) and microwave (MWA), non-thermal ablation, irreversible electroporation (IRE) cross-comparisons multiple ablative modalities for hepatocellular carcinoma (HCC) treatment remain scarce. Thus, we investigated therapeutic outcomes different three in early stage HCC.A total 322 consecutive patients with 366 HCCs (mean tumor size ± standard deviation: 1.7 0.9 cm) who underwent RFA (n = 216, 59.0%), MWA 91, 28.3%),...
To investigate changes in skeletal muscle mass and fat fraction patients with metabolic dysfunction-associated steatotic liver disease (MASLD) type 2 diabetes mellitus (T2DM) undergoing treatment Semaglutide for 6months. This single-arm pilot study included 21 MASLD who received semaglutide T2DM. Body weight, parameters, enzymes, fibrosis markers, index (cm2/m2), (%) at the L3 level using two-point Dixon method on magnetic resonance imaging (MRI), as well steatosis stiffness assessed...
The Contrast-Enhanced Ultrasound Liver Imaging Reporting and Data System (CEUS LI-RADS) was introduced for classifying suspected hepatocellular carcinoma (HCC). However, it cannot be applied to Sonazoid. We assessed the diagnostic usefulness of a modified CEUS LI-RADS HCC non-HCC malignancies based on sensitivity, specificity, positive predictive value (PPV), negative (NPV). Patients with chronic liver disease at risk were evaluated retrospectively. Nodules ≥1 cm arterial phase...
Background Nonalcoholic fatty liver disease (NAFLD) is common in the general population but identifying patients with high-risk nonalcoholic steatohepatitis (NASH) who are candidates for pharmacologic therapy remains a challenge. Purpose To develop score to identify NASH, defined as NASH an NAFLD activity (NAS) of 4 or greater and clinically significant fibrosis (stage 2 [F2] higher). Materials Methods This was cross-sectional secondary analysis data prospectively collected between April...
A retrospective analysis.
The aim of this study was to compare the diagnostic performance Contrast-Enhanced US Liver Imaging Reporting and Data System (CEUS LI-RADS) version 2017, which includes portal- late-phase washout as a major imaging feature, with that modified CEUS LI-RADS, Kupffer-phase findings feature. Participants at risk hepatocellular carcinoma (HCC) treatment-naïve hepatic lesions (≥1 cm) were recruited underwent Sonazoid-enhanced US. Arterial phase hyperenhancement (APHE), time, echogenicity in...
ABSTRACT Stereotactic body radiation therapy (SBRT) is a highly effective treatment for lung cancer; however, challenges arise from tumor motion induced by respiration. The CyberKnife system, incorporating both fiducial‐based and fiducial‐free tracking modalities, aims to mitigate these challenges, yet recognition can be compromised overlapping bone structures. This study introduces novel suppression imaging technique kilovolt X‐ray using generative adversarial networks (GANs) enhance in...
Abstract A 61-year-old female patient with advanced intrahepatic cholangiocarcinoma diagnosed based on imaging and tumor biopsy findings was treated combination therapy comprising gemcitabine, cisplatin, durvalumab. After eight cycles of durvalumab two subsequent maintenance immunotherapy, significant shrinkage enabled conversion surgery R0 resection. The immune microenvironment has a critical role in predicting the efficacy combined immunotherapy some types cancer; however, its remains...
Breast implant-associated anaplastic large cell lymphoma (BIA-ALCL) is a type of lymphoma, that was first described in the revised 4th edition WHO Classification Tumors released 2017. The textured implants are thought to form bacterial biofilm and cause chronic inflammation, which may be associated with tumorigenesis. We present 50-year-old woman who had past medical history breast reconstruction implant 20 years ago. She presented abdominal distension caused by intraperitoneal...
Abstract A 76‐year‐old man underwent an operation for lung squamous cell carcinoma in the right lower lobe, followed by initial adjuvant therapy with atezolizumab, antibody against anti‐programmed death‐ligand 1 (PD‐L1). On day 4 after atezolizumab treatment, patient developed general malaise and fatigue. He was diagnosed atezolizumab‐induced sclerosing cholangitis. Steroid treatment started, patient's condition, including symptoms, laboratory data imaging findings, improved. Antibiotic...
Background: The purpose of this study was to explore the effect lifestyle modification, mainly daily aerobic exercise, on coronary atherosclerosis in patients with artery disease (CAD). Methods and Results: A 6-month prospective observational conducted 84 CAD receiving pravastatin treatment order evaluate relationship between particular plaque volume as assessed by intravascular ultrasound (IVUS). Lifestyle during period the-lifestyle modification score. significant decrease 12.9% observed...
CD4+CD25highFOXP3+ regulatory T (Treg) cells, which include thymus-derived and peripherally induced play a central role in immune regulation, are therefore crucial to prevent graft-versus-host disease (GVHD). The increasing use of allogeneic hematopoietic stem cell transplantation (allo-HSCT) for elderly patients with thymus regression, our case allo-HSCT shortly after total thymectomy, raised questions about the activity Treg cells otherwise indistinguishable.We found that despite...
To compare the diagnostic performance based on modified CEUS Liver Imaging Reporting and Data System (LI-RADS), which includes Kupffer-phase findings as a major imaging feature, with that of CT MRI (CT/MRI) LI-RADS for liver nodules in patients at high risk HCC.A total 120 were included this retrospective study. The median size lesions was 20.0 mm (interquartile range, 14.0-30.8 mm). Of these lesions, 90.0% (108 120) confirmed HCCs, 6.7% (8 intrahepatic cholangiocarcinomas, 1.7% (2...
Currently, transnasal esophagogastroduodenoscopy using an ultrathin endoscope is being widely carried out as a screening test for early gastric cancer. We compared the diagnostic utility of with that conventional in detecting 42 lesions cancer had diameter ≤20 mm. Only 27 (64%) could be accurately diagnosed esophagogastroduodenoscopy. In nine (22%), we failed to discern whether they were malignant. Six (14%) not even detected. found was inadequate, especially case located upper third region...
Abstract Forty-four angiograms, which were performed within three weeks of the onset hypertensive cerebral haemorrhage, have been reviewed. Leakage contrast material from vessels into haematoma was observed in five cases angiography a few hours after apoplectic attack. It appears reasonable to presume that shorter interval between haemorrhage and angiography, higher incidence extravasation haematoma.
Background In the S pectra apheresis instrument ( T erumo BCT ), both manual pectra‐ MNC ) and automated A uto) programs have been widely used to collect peripheral blood progenitor cells PBPC s). However, direct comparison of these remains extremely limited. Study Design Methods We investigated 188 collections products from autologous (patient) allogeneic (donor) subjects analyzed a subset 89 products. Twenty‐nine who received for 2 consecutive days using were also evaluated with paired...