A5001421629- Atrial Fibrillation Management and Outcomes
- Coronary Interventions and Diagnostics
- Cardiac Imaging and Diagnostics
- Cardiac Arrhythmias and Treatments
- Cardiac electrophysiology and arrhythmias
- Lipoproteins and Cardiovascular Health
- Antiplatelet Therapy and Cardiovascular Diseases
- Acute Myocardial Infarction Research
- Venous Thromboembolism Diagnosis and Management
- Cardiovascular Function and Risk Factors
- Heart Failure Treatment and Management
- Cardiac pacing and defibrillation studies
- Cerebrovascular and Carotid Artery Diseases
- Aortic Thrombus and Embolism
- Advanced MRI Techniques and Applications
- ECG Monitoring and Analysis
- Cardiac Valve Diseases and Treatments
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Cardiac Arrest and Resuscitation
- Cardiac Structural Anomalies and Repair
- Aortic aneurysm repair treatments
- Blood Pressure and Hypertension Studies
- Health Systems, Economic Evaluations, Quality of Life
- Ion channel regulation and function
- Cardiac, Anesthesia and Surgical Outcomes
Osaka Police Hospital
2006-2024
Osaka University
1982-2024
Uji Hospital
2024
Fukujuji Hospital
2023-2024
Nihon University
2012-2021
National Cerebral and Cardiovascular Center
2021
Nihon University Itabashi Hospital
2017-2020
Japanese Circulation Society
2013-2019
Osaka Ekisaikai Hospital
2019
Doshisha University
2015-2019
There are limited data from randomized trials evaluating the use of antithrombotic therapy in patients with atrial fibrillation and stable coronary artery disease.
Current guidelines call for high-intensity statin therapy in patients with cardiovascular disease on the basis of several previous "more versus less statins" trials. However, no clear evidence more statins has been established an Asian population. In this prospective, multicenter, randomized, open-label, blinded end point study, 13 054 Japanese stable coronary artery who achieved low-density lipoprotein cholesterol (LDL-C) <120 mg/dL during a run-in period (pitavastatin 1 mg/d) were...
Background: It has been suggested that intensive lipid-lowering therapy using statins significantly decreases atheromatous plaque volume. The effect of rosuvastatin on volume in patients with stable coronary artery disease (CAD), including those receiving prior therapy, was examined the present study. Methods and Results: A 76-week open-label trial performed at 37 centers Japan. Eligible began treatment 2.5 mg/day, which could be increased 4-week intervals to ≤20 mg/day. total 214 underwent...
Background: Whether epicardial adipose tissue (EAT) is independently associated with atrial fibrillation (AF) and outcome after catheter ablation (CA) for AF remains unclear. Methods Results: Three-dimensional volume-rendering reconstructed images of EAT (total EAT) surrounding the left atrium (LA-EAT) were measured on 320-row multidetector computed tomography in 40 patients (paroxysmal [PAF], n=24; persistent [PerAF], n=16) who underwent CA, 37 age-matched control patients. volumes as...
Background: YUKAWA is a 12-week, randomized, double-blind, placebocontrolled, phase 2 study evaluating the efficacy and safety of evolocumab (AMG 145) in statin-treated Japanese patients at high cardiovascular risk. Methods Results: 310 eligible receiving stable statin (±ezetimibe) therapy were randomized to 1 6 treatments: placebo every weeks (Q2W) or monthly (QM), 70mg 140mg Q2W, 280mg 420mg QM. The primary endpoint was percentage change from baseline low-density lipoprotein cholesterol...
Evolocumab (AMG 145), a fully human monoclonal antibody against PCSK9, significantly reduced low-density lipoprotein cholesterol (LDL-C) levels in phase 2 and 3 studies. This study evaluated the efficacy safety of evolocumab plus atorvastatin Japanese patients with hyperlipidemia or mixed dyslipidemia high cardiovascular risk. Patients were randomized to 5 20 mg/day for 4 weeks. Subsequently, underwent second randomization 140 mg biweekly (Q2W) 420 monthly (QM) placebo Q2W QM. Coprimary end...
The global EINSTEIN DVT and PE studies compared rivaroxaban (15 mg twice daily for 3 weeks followed by 20 once daily) with enoxaparin/vitamin K antagonist therapy demonstrated non-inferiority efficacy superiority major bleeding. Owing to differences in targeted anticoagulant intensities Japan, Japanese patients were not enrolled into the studies. Instead, a separate study of deep vein thrombosis (DVT) and/or pulmonary embolism (PE) was conducted, which standard care reduced dose...
Abstract Background Large‐scale investigations on the use of oral anticoagulants including direct (DOACs) in patients with atrial fibrillation (AF) have not included Japanese patients. Methods We established multicenter SAKURA AF Registry to support prospective observational research status anticoagulation treatment, especially DOAC, for Japan. enrolled 3266 treated warfarin ( n =1577) or any 4 DOACs =1689) from 63 institutions (2 cardiovascular centers, 13 affiliated hospitals community...
Abstract Aims To clarify the real-world clinical status and prognosis of elderly very non-valvular atrial fibrillation (NVAF) patients, more than 30 000 patients with NVAF aged ≥75 years were enrolled in ANAFIE Registry. Methods results This multicentre, prospective, observational study followed Japan for ∼2 years. Among 32 275 (mean age, 81.5 years; men, 57.3%; mean CHA2DS2-VASc score, 4.5), 2445 (7.6%) not receiving oral anticoagulants (OACs) 29 830 (92.4%) given OACs. Of these, 21 585...
Recently, it has been reported that the luminal diameter shows phasic changes after stenting: progression of narrowing followed by its regression. To elucidate mechanisms involved in stenting, we examined neointimal thickness and appearance neointima a series angiographic angioscopic observations for 3 years stent implantation.In 12 patients who received Wiktor coronary stent, serial examinations were performed immediately, 2 to 4 weeks, months, 6 stenting without repetition angioplasty....
Although increased epicardial adipose tissue (EAT) volume is known to be associated with prevalence of atrial fibrillation (AF), the exact mechanisms are unclear. Therefore, we investigated whether EAT locations were high dominant frequency (DF) sites or complicated fractionated electrogram during AF.Three-dimensional reconstruction computed tomography images depicting volumes (obtained by 320-detector-row multislice tomography) merged NavX-based DF and maps obtained AF for 16 patients...
Background: The aim of this study was to elucidate the time course atorvastatin-induced changes in vulnerable plaque using angioscopy and intravascular ultrasound (IVUS). Methods Results: Fifty-seven hypercholesterolemic patients with coronary artery disease (CAD) were treated atorvastatin (10-20 mg/day) for 80 weeks then plaques evaluated IVUS. Angioscopic images classified into 6 grades (0-5) based on yellow color intensity. A 20-mm segment containing angioscopically-identified also...
Off-label dosing of direct oral anticoagulants (DOACs) is encountered clinically among patients with atrial fibrillation (AF), although data on the clinical outcomes over- and under-dosing are lacking in Japan.
Acute decompensated heart failure (ADHF) is often accompanied by liver congestion through increased right atrial pressure (RAP). Liver stiffness (LS) assessed non-invasively using transient elastography related to RAP and in patients with general HF. We investigated the relationship of LS clinical echocardiographic variables outcomes ADHF.Methods Results:The subjects were 105 ADHF admitted hospital between October 2016 June 2017. Patients divided into 2 groups based on median at admission...