Nobuhiro Tanaka
A5037059275- Coronary Interventions and Diagnostics
- Cardiac Imaging and Diagnostics
- Acute Myocardial Infarction Research
- Cardiovascular Function and Risk Factors
- Antiplatelet Therapy and Cardiovascular Diseases
- Cerebrovascular and Carotid Artery Diseases
- Cardiac Valve Diseases and Treatments
- Peripheral Artery Disease Management
- Cardiac electrophysiology and arrhythmias
- Cardiovascular Health and Disease Prevention
- Cardiac, Anesthesia and Surgical Outcomes
- Vascular Procedures and Complications
- Advanced MRI Techniques and Applications
- Cardiac Arrest and Resuscitation
- Blood Pressure and Hypertension Studies
- Mechanical Circulatory Support Devices
- Cardiac Structural Anomalies and Repair
- Cardiac Arrhythmias and Treatments
- Cardiac pacing and defibrillation studies
- Venous Thromboembolism Diagnosis and Management
- Heart Rate Variability and Autonomic Control
- Atrial Fibrillation Management and Outcomes
- Cardiac Ischemia and Reperfusion
- Cardiomyopathy and Myosin Studies
- Health Systems, Economic Evaluations, Quality of Life
Tokyo Medical University Hachioji Medical Center
2016-2025
Tokyo Medical University
2014-2024
Ajou University
2023
Amsterdam University Medical Centers
2022
Japanese Circulation Society
2015-2021
Kokura Memorial Hospital
2015-2020
Seoul Medical Center
2019
Gifu Heart Center
2018
Kyushu Hospital
2017
Tokyo Medical University Hospital
2013-2015
To evaluate the clinical application of second derivative fingertip photoplethysmogram waveform, we performed drug administration studies (study 1) and epidemiological 2). In study 1, ascending aortic pressure was recorded simultaneously with its in 39 patients a mean+/-SD age 54+/-11 years. The augmentation index defined as ratio height late systolic peak to that early pulse. consists an a, b, c, d wave systole e diastole. Ascending increased after injection 2.5 microg angiotensin from...
Background: Coronary microvascular dysfunction (CMD) is an important contributor to angina syndromes.Recently, two distinct endotypes were identified using combined assessment of coronary flow reserve (CFR) and minimal resistance (MR), termed structural functional CMD. Aims:We aimed assess the relevance CFR MR in patients with no obstructive arteries.Methods: Patients chronic syndromes (CCS) non-obstructive artery disease (fractional [FFR] ≥0.80) selected (N=1,102).Functional CMD was defined...
The microvascular resistance reserve (MRR) was introduced as a means to characterize the vasodilator capacity of coronary microcirculation while accounting for influence concomitant epicardial disease and impact administration potent vasodilators on aortic pressure. This study aimed evaluate diagnostic prognostic performance MRR.A total 1481 patients with stable symptoms clinical indication angiography were included from global ILIAS Registry. MRR derived function flow (CFR) divided by...
Background Although a very simple method of measuring brachial - ankle pulse wave velocity (baPWV) has become available in clinical setting, whether baPWV can predict future cardiovascular events remains uncertain. We examined is predictor patients with acute coronary syndrome (ACS). Methods and Results measurement was performed 215 consecutive ACS. During the follow-up period (26±10 months), 46 experienced post-hospitalization (18 major event (eg, stroke, re-admission for heart failure or...
Background Normal values for echocardiographic measurements and the relationship between these parameters age in a large Japanese population are still unknown. Methods Results A total of 700 healthy aged 20-79 years underwent 2-dimensional Doppler echocardiography at collaborating institutions. The respective mean obtained men women were as follows: septal wall thickness, 0.9±0.1 0.8±0.1 cm; posterior left ventricular (LV) diastolic diameter, 4.8±0.4 4.4±0.3 LV systolic 3.0±0.4 2.8±0.3...
The aim of this study was to investigate the clinical outcomes patients deferred from coronary revascularization on basis instantaneous wave-free ratio (iFR) or fractional flow reserve (FFR) measurements in stable angina pectoris (SAP) and acute syndromes (ACS). Assessment stenosis severity with pressure guidewires is recommended determine need for myocardial revascularization. safety deferral pooled per-protocol population (n = 4,486) DEFINE-FLAIR (Functional Lesion Intermediate Stenosis...
There are limited data on the clinical implications of total physiologic atherosclerotic burden assessed by invasive studies in patients with coronary artery disease. We investigated prognostic sum fractional flow reserve (FFR) three vessels (3V-FFR). A 1136 underwent FFR measurement (3V FFR-FRIENDS study, NCT01621438). The were classified into high and low 3V-FFR groups according to median value (2.72). primary endpoint was major adverse cardiac events (MACE, a composite death, myocardial...
Background Scarce data exist about the outcomes after percutaneous coronary intervention ( PCI ) in old patients. This study sought to provide an overview of elderly patients, especially nonagenarians, a Japanese large prospective nationwide registry. Methods and Results We analyzed 562 640 patients undergoing (≥60 years age) from 1018 hospitals between 2014 2016 J-PCI (Japanese intervention) Among them, 10 628 (1.9%), including 6780 (1.2%) with acute syndrome ACS 3848 (0.7%) stable artery...
Background: Fractional flow reserve (FFR)-guided percutaneous coronary intervention (PCI) is superior to angiography-guided PCI.The clinical uptake of FFR has been limited, however, by the need advance a wire in artery, additional time required and for hyperaemic agents which can cause patient discomfort.FFR derived from routine angiography eliminates these issues. Aims:The aim this study was assess diagnostic performance accuracy three-dimensional quantitative (3D-QCA)-based vessel (vFFR)...
Background In the absence of obstructive coronary stenoses, abnormality noninvasive stress tests (NIT) in patients with chronic syndromes may indicate myocardial ischemia nonobstructive arteries (INOCA). The differential prognosis INOCA according to presence microvascular dysfunction (CMD) and incremental prognostic value CMD intracoronary physiologic assessment on top NIT information remains unknown. Methods Results From international multicenter registry (ILIAS [Inclusive Invasive...
To determine why upper limb blood pressure measurement underestimates the vasodilator effects of nitroglycerin on lowering ascending aortic systolic pressure, we studied 24 patients (58 +/- 11 years, mean SD). Ascending and radial artery pulse calibrated by cuff at brachial were recorded simultaneously before 5 minutes after sublingual administration 0.3 mg nitroglycerin. Waves analyzed a signal processor, fourth derivative wave was used to find early (S1) late (S2) shoulders (S1 corresponds...
Background: The recently developed real-time 3-dimensional echocardiography (RT3DE) is a promising imaging method to quantify cardiac chamber volumes and their functions in clinical practice. However, normal reference values of RT3DE parameters have not been fully investigated large, healthy Japanese population. Methods Results: This study consisted 410 subjects aged from 20 69 years who had at one the 23 collaborating institutions. All no history disease risk factors. mean men women were as...
To evaluate the first experience of real-time instantaneous wave-free ratio (iFR) measurement by clinicians.