A5088365375- Muscle activation and electromyography studies
- Schizophrenia research and treatment
- Sports injuries and prevention
- Lower Extremity Biomechanics and Pathologies
- Coronary Interventions and Diagnostics
- Knee injuries and reconstruction techniques
- Foot and Ankle Surgery
- Cerebral Palsy and Movement Disorders
- Children's Physical and Motor Development
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Aquatic Invertebrate Ecology and Behavior
- Phonocardiography and Auscultation Techniques
- Cardiac Arrhythmias and Treatments
- Streptococcal Infections and Treatments
- Stroke Rehabilitation and Recovery
- Cardiac Imaging and Diagnostics
- Respiratory Support and Mechanisms
- Neuroscience and Music Perception
- Mollusks and Parasites Studies
- Balance, Gait, and Falls Prevention
- Pharmaceutical studies and practices
- Bipolar Disorder and Treatment
- Cardiovascular Effects of Exercise
- Parkinson's Disease Mechanisms and Treatments
- Motor Control and Adaptation
KU Leuven
2016-2025
Janssen (Belgium)
2005-2021
Imelda Hospital
2003-2019
Isala
2016
Janssen (United States)
2012
Johnson & Johnson (United States)
2006-2007
Universitair Ziekenhuis Leuven
1991
Royal Museum for Central Africa
1990
We hypothesized that percutaneous coronary intervention (PCI) preceded by early treatment with abciximab plus half-dose reteplase (combination-facilitated PCI) or alone (abciximab-facilitated would improve outcomes in patients acute ST-segment elevation myocardial infarction, as compared administered immediately before the procedure (primary PCI).In this international, double-blind, placebo-controlled study, we randomly assigned infarction who presented 6 hours less after onset of symptoms...
Freezing in Parkinson's disease is a severe and disabling problem of unknown aetiology.The aim this study was to analyse the temporal pattern magnitude electromyographic activity lower limb muscles just before freezing compare with voluntary stop ongoing gait.We recruited 11 patients mean age 64.8 years (SD 5.1) Uni®ed Parkinson Disease Rating Scale (part IIIÐoff) score 29 7.9).Within standard 3D gait laboratory setting, surface (EMG) data tibialis anterior (TA) gastrocnemius (GS) were...
The aim of this study was to investigate the clinical outcomes patients deferred from coronary revascularization on basis instantaneous wave-free ratio (iFR) or fractional flow reserve (FFR) measurements in stable angina pectoris (SAP) and acute syndromes (ACS). Assessment stenosis severity with pressure guidewires is recommended determine need for myocardial revascularization. safety deferral pooled per-protocol population (n = 4,486) DEFINE-FLAIR (Functional Lesion Intermediate Stenosis...
Background Biatrial, extensive, and complex ablation strategies have been published for the treatment of neurally mediated syncope, sinus node dysfunction, functional atrioventricular block. We developed a less extensive more specific approach compared with previously cardioneuroablation strategies, called cardio-neuromodulation. It is based on tailored vagolysis sinoatrial through partial anterior right-ganglionated plexus, preferentially right-sided approach. Methods Patients syncope were...
Abstract Background Atabecestat, a potent brain-penetrable inhibitor of BACE1 activity that reduces CSF amyloid beta (Aβ), was developed for oral treatment Alzheimer’s disease (AD). The long-term safety and effect atabecestat on cognitive performance in participants with predementia AD two phase 2 studies were assessed. Methods In the placebo-controlled double-blind parent ALZ2002 study, aged 50 to 85 years randomized (1:1:1) placebo or 10 mg once daily (later reduced 5 25 mg) 6 months....
Impaired muscle activation may predispose subjects to develop chronic ankle instability. It has been suggested that impairments are found not only in structures around the injured but also more proximal joint complexes.Subjects with instability were expected show later onset times for lower limb and trunk when compared control subjects. They less variability patterns group.Controlled laboratory study.Thirty 10 participated study. The of activity 14 muscles was measured during transition from...
Abstract Freezing of gait (FOG) is an incapacitating problem in Parkinson's disease that difficult to manage therapeutically. We tested the hypothesis impaired rhythm and amplitude control a common mechanism freezing which also present during other rhythmic tasks. Therefore, we compared occurrence spatiotemporal profiles episodes upper limb motion, lower FOG. Eleven freezers, 12 non‐freezers, 11 controls performed bilateral finger movement task. The triggering effect speed, amplitude,...
This open-label, randomized, 2-way crossover study characterized the pharmacokinetics and pharmacodynamics of a transdermal contraceptive patch norgestimate-containing oral contraceptive. Healthy women (n = 34) applied once weekly for 3 consecutive weeks during each 2 cycles received an 21 days cycles. Plasma concentrations norelgestromin ethinyl estradiol peaked waned after daily administration, whereas they rose reached steady-state levels first application. Norelgestromin exposure was...
Background Unilateral diaphragm dysfunction (UDD) is an underdiagnosed cause of dyspnoea. Inspiratory muscle training (IMT) the only conservative treatment for UDD, but mechanisms improvement are unknown. We characterised effects IMT on dyspnoea, exercise tolerance and respiratory function in people with UDD. Methods 15 UDD (73% male, 61±8 years) were randomised to 6 months (50% maximal inspiratory mouth pressure ( P I,max ), n=10) or sham (10% , n=5) (30 breaths twice per day). was...
Increases in serum prolactin concentrations after administration of risperidone have been attributed, by some, to the availability paliperidone plasma. This double-blind, randomized, parallel-group study patients with schizophrenia compared following extended-release and immediate-release tablets. At steady state, doses administered resulted a similar exposure pharmacologically active fraction (i.e. + paliperidone), respectively. Eligible were randomized either 12 mg on days 1—6 or 2 day 1 4...
Cognition is important in many sports, for example, making split-second-decisions under pressure, or memorising complex movement sequences. The dual-task (DT) paradigm an ecologically valid approach the assessment of cognitive function conjunction with motor demands. This study aimed to determine impact impaired intelligence on DT performance. task required balancing one leg a beam, and was multiple-object-tracking (MOT) assessing dynamic visual-search capacity. sample included 206...
<h3>Importance</h3> Invasive physiologic indices such as fractional flow reserve (FFR) and instantaneous wave-free ratio (iFR) are used in clinical practice. Nevertheless, comparative prognostic outcomes of iFR-guided FFR-guided treatment patients with type 2 diabetes have not yet been fully investigated. <h3>Objective</h3> To compare 1-year or without the Functional Lesion Assessment Intermediate Stenosis to Guide Revascularization (DEFINE-FLAIR) trial. <h3>Design, Setting,...
Evaluating respiratory drive presents challenges due to the obtrusiveness and impracticality of current methods like functional magnetic resonance imaging (fMRI). Electromyography (EMG) offers a surrogate measure muscles, allowing determination both magnitude timing muscle activation. The reflects level activation, while indicates onset offset activity relative specific events, such as inspiratory flow activation other muscles. These metrics are critical for understanding coordination...
This study aimed to characterize scapular muscle timing in stroke patients with and without shoulder pain. Muscle activity of upper trapezius, lower serratus anterior, infraspinatus anterior deltoid was measured (Delsys Trigno surface EMG system, US) 14 healthy controls (dominant side) 30 (hemiplegic whom 10 had impingement-like Participants performed 45° full range anteflexion, two load conditions. The impact group, anteflexion height, condition assessed for onset offset the different...
Study Design Controlled laboratory study with a prospective cohort design. Background Postural stability deficits during single-leg stance have been reported in persons anterior cruciate ligament (ACL) injury, ACL reconstruction, and chronic ankle instability. It remains unclear whether impaired postural is consequence or cause of these injuries. Objectives To prospectively investigate predict noncontact lower extremity Methods Fifty injury-free female athletes performed transition task from...
Pelvic floor exercises are invaluable for regaining continence but mechanisms not fully understood. To contribute to the understanding of these we investigated contraction sequence superficial vs deep pelvic muscles in 6 positions continent and incontinent women.The onset was recorded by perineal intravaginal surface electromyography 32 50 women. The agreement between recordings calculated with kappa statistic percent agreement. Differences muscle contractions reported as median IQR.Perineal...
Paliperidone extended‐release tablet (paliperidone ER) is a centrally active dopamine D 2 ‐ and serotonergic 5‐HT 2A ‐receptor antagonist that registered for the treatment of schizophrenia. The controlled rate release paliperidone from ER formulation designed to have slower absorption rate, which results in gradual ascending plasma concentrations with observed maximum occurring at 24 hours after dosing on first day. On subsequent days, provides minimal fluctuations concentrations. eliminated...