A5065107885- Peripheral Neuropathies and Disorders
- Botulinum Toxin and Related Neurological Disorders
- Pain Mechanisms and Treatments
- Hereditary Neurological Disorders
- Acute Myocardial Infarction Research
- Parkinson's Disease Mechanisms and Treatments
- Myasthenia Gravis and Thymoma
- Coronary Interventions and Diagnostics
- Cardiac Imaging and Diagnostics
- Cardiac Valve Diseases and Treatments
- Peripheral Nerve Disorders
- Infective Endocarditis Diagnosis and Management
- Diabetic Foot Ulcer Assessment and Management
- Cardiac pacing and defibrillation studies
- Long-Term Effects of COVID-19
- Parkinson's Disease and Spinal Disorders
- Genetic Neurodegenerative Diseases
- Cardiac Arrhythmias and Treatments
- Atrial Fibrillation Management and Outcomes
- Diabetes Management and Research
- Heart Failure Treatment and Management
- Lysosomal Storage Disorders Research
- Multiple Sclerosis Research Studies
- Neurological disorders and treatments
- Amyotrophic Lateral Sclerosis Research
Aarhus University Hospital
2016-2025
Aarhus University
2015-2025
Odense University Hospital
2011-2024
University of Southern Denmark
2024
Steno Diabetes Centers
2021-2024
Ludwig-Maximilians-Universität München
2024
Friedrich Baur Stiftung
2024
Erasmus MC
2022-2023
University of Michigan
1995-2023
Columbia University
2022
For the treatment of myocardial infarction with ST-segment elevation, primary angioplasty is considered superior to fibrinolysis for patients who are admitted hospitals facilities. Whether this benefit maintained require transportation from a community hospital center where invasive available uncertain.We randomly assigned 1572 acute or accelerated intravenous alteplase; 1129 were enrolled at 24 referral and 443 5 invasive-treatment centers. The study end point was composite death, clinical...
We hypothesized that percutaneous coronary intervention (PCI) preceded by early treatment with abciximab plus half-dose reteplase (combination-facilitated PCI) or alone (abciximab-facilitated would improve outcomes in patients acute ST-segment elevation myocardial infarction, as compared administered immediately before the procedure (primary PCI).In this international, double-blind, placebo-controlled study, we randomly assigned infarction who presented 6 hours less after onset of symptoms...
A new artificial aortic valve prosthesis was developed for implantation by the transluminal catheter technique without thoracotomy or extracorporal circulation. The heart prepared mounting a porcine into an expandable stent. Before implantation, stent-valve mounted on balloon and compressed around deflated balloon. then advanced retrogradely to ascending aorta root in anaesthetized pigs. Implantation performed inflation which expanded diameter exceeding internal of vesselemdash thus ensuring...
Motor function in type 2 diabetes is largely unknown. In 36 diabetic patients and control subjects matched for sex, age, weight, height, physical activity, strength of flexors extensors at elbow, wrist, knee, ankle was assessed isokinetic dynamometry. The degree neuropathy determined by clinical scores, nerve conduction studies, quantitative sensory testing. Eventually, all results were summed to obtain a rank-sum score (NRSS). nephropathy retinal condition also evaluated. Diabetic had 17...
Guillain-Barré syndrome is a heterogeneous disorder regarding the clinical presentation, electrophysiological subtype and outcome. Previous single country reports indicate that may differ among regions, but no systematic comparative studies have been conducted. Comparative are required to identify factors determining disease susceptibility, variation prognosis, improve diagnostic criteria. The International Syndrome Outcome Study prospective, observational cohort study including all patients...
Eculizumab is effective and well tolerated in patients with antiacetylcholine receptor antibody-positive refractory generalized myasthenia gravis (gMG; REGAIN; NCT01997229). We report an interim analysis of open-label extension REGAIN, evaluating eculizumab's long-term safety efficacy.Eculizumab (1,200 mg every 2 weeks for 22.7 months [median]) was administered to 117 patients.The profile eculizumab consistent no cases meningococcal infection were reported during the period. Myasthenia...
OBJECTIVE To study incident diabetic polyneuropathy (DPN) prospectively during the first 13 years after a screening-based diagnosis of type 2 diabetes and determine associated risk factors for development DPN. RESEARCH DESIGN AND METHODS We assessed DPN longitudinally in Danish arm Anglo-Danish-Dutch Intensive Treatment Diabetes Primary Care (ADDITION) using Michigan Neuropathy Screening Instrument questionnaire (MNSIQ), defining with scores ≥4. Risk present at were estimated Cox...
Background— Early stent valve thrombosis after transcatheter aortic implantation (TAVI) is a rare complication, which diagnosed based on the appearance of clinical symptoms heart failure and echocardiographic findings. After TAVI, transthoracic echocardiography performed to assess (THV) function. However, preliminary reports indicate potential additive value multidetector computed tomography (MDCT) for diagnosis THV thrombosis. We sought determine MDCT frequency this complication...
Abstract Background and purpose Among post‐COVID‐19 symptoms, fatigue is reported as one of the most common, even after mild acute infection, cause fatigue, myopathy diagnosed by electromyography has been proposed in previous reports. This study aimed to explore histopathological changes patients with fatigue. Methods Sixteen (mean age = 46 years) complaints myalgia, or weakness persisting for up 14 months were included. In all patients, quantitative muscle biopsies analyzed light electron...
Aims Acute myocardial infarction (AMI) is categorized, according to the presenting electrocardiogram, into non-ST-elevation (non-STEMI), ST-elevation (STEMI), or bundle branch block (BBBMI). Data on prognostic significance of these categories mainly originate from voluntary based registries large-scale clinical trials and may be hampered by selection information bias. The aim this historical cohort study was evaluate different AMI in an unselected cohort. Methods results From 1 November 1999...
Distal embolization during primary percutaneous coronary intervention (PCI) for ST-elevation myocardial infarction may result in reduced perfusion, infarct extension, and impaired prognosis.In a prospective randomized trial, we studied the effect of routine thrombectomy 215 patients with ST-segment-elevation lasting <12 hours undergoing PCI. Patients were to pretreatment or standard The end point was salvage measured by sestamibi SPECT, calculated as difference between area at risk final...
Aims The majority of patients with ST-elevation myocardial infarction (STEMI) are admitted to local hospitals without primary percutaneous coronary intervention (primary PCI) facilities. Acute transferral an interventional centre is necessary treat these PCI. present study assessed the reduction in treatment delay achieved by pre-hospital diagnosis and referral directly centre.