Thomas Harbo
A5075020182- Peripheral Neuropathies and Disorders
- Hereditary Neurological Disorders
- Long-Term Effects of COVID-19
- Peripheral Nerve Disorders
- Myasthenia Gravis and Thymoma
- Acute Ischemic Stroke Management
- Stroke Rehabilitation and Recovery
- Cerebrovascular and Carotid Artery Diseases
- Nerve injury and regeneration
- Multiple Sclerosis Research Studies
- Parkinson's Disease and Spinal Disorders
- Venous Thromboembolism Diagnosis and Management
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Autoimmune Neurological Disorders and Treatments
- Monoclonal and Polyclonal Antibodies Research
- COVID-19 and Mental Health
- Muscle and Compartmental Disorders
- Psychosomatic Disorders and Their Treatments
- Botulinum Toxin and Related Neurological Disorders
- Neurobiology of Language and Bilingualism
- Antifungal resistance and susceptibility
- Intensive Care Unit Cognitive Disorders
- Myofascial pain diagnosis and treatment
- Protein Tyrosine Phosphatases
- Sports Performance and Training
Aarhus University Hospital
2016-2025
Aarhus University
2012-2025
Erasmus MC
2018-2023
Health and Education Research Management and Epidemiologic Services (United States)
2023
University of Michigan
2023
Capital Region of Denmark
2023
Columbia University
2022
University of Milano-Bicocca
2022
Aalborg University
2021
Rigshospitalet
2021
To revise the 2010 consensus guideline on chronic inflammatory demyelinating polyradiculoneuropathy (CIDP). Seventeen disease experts, a patient representative, and two Cochrane methodologists constructed 12 Population/Intervention/Comparison/Outcome (PICO) questions regarding diagnosis treatment to guide literature search. Data were extracted summarized in GRADE summary of findings (for PICOs) or evidence tables diagnostic PICOs). Statements prepared according Evidence-to-Decision...
To revise the 2010 consensus guideline on chronic inflammatory demyelinating polyradiculoneuropathy (CIDP).Seventeen disease experts, a patient representative, and two Cochrane methodologists constructed 12 Population/Intervention/Comparison/Outcome (PICO) questions regarding diagnosis treatment to guide literature search. Data were extracted summarized in GRADE summary of findings (for PICOs) or evidence tables diagnostic PICOs).Statements prepared according Evidence-to-Decision frameworks....
Guillain-Barré syndrome is a heterogeneous disorder regarding the clinical presentation, electrophysiological subtype and outcome. Previous single country reports indicate that may differ among regions, but no systematic comparative studies have been conducted. Comparative are required to identify factors determining disease susceptibility, variation prognosis, improve diagnostic criteria. The International Syndrome Outcome Study prospective, observational cohort study including all patients...
Abstract Background and purpose Among post‐COVID‐19 symptoms, fatigue is reported as one of the most common, even after mild acute infection, cause fatigue, myopathy diagnosed by electromyography has been proposed in previous reports. This study aimed to explore histopathological changes patients with fatigue. Methods Sixteen (mean age = 46 years) complaints myalgia, or weakness persisting for up 14 months were included. In all patients, quantitative muscle biopsies analyzed light electron...
Guillain-Barré syndrome (GBS) is an acute polyradiculoneuropathy. Symptoms may vary greatly in presentation and severity. Besides weakness sensory disturbances, patients have cranial nerve involvement, respiratory insufficiency, autonomic dysfunction pain. To develop evidence-based guideline for the diagnosis treatment of GBS, using Grading Recommendations, Assessment, Development Evaluation (GRADE) methodology a Task Force (TF) European Academy Neurology (EAN) Peripheral Nerve Society (PNS)...
Background and purpose: For treatment of multifocal motor neuropathy (MMN), we hypothesized that (i) infusion equivalent dosages subcutaneous immunoglobulin (SCIG) is as effective intravenous (IVIG) (ii) at home associated with a better quality life. Methods: In randomized single‐blinded cross‐over study, nine IVIG responsive patients were allocated to receive either SCIG or for period three intervals and, subsequently, crossed over the other treatment. Primary end‐points dynamometric...
We hypothesized that subcutaneous administration of immunoglobulins (SCIG) in chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) is feasible, safe and superior to treatment with saline for the performance muscle strength.Thirty patients motor involvement maintenance therapy intravenous immunoglobulin (IVIG) fulfilling EFNS/PNS criteria CIDP, aged 18-80 years, were randomized either SCIG at a dose corresponding their pre-study IVIG or given twice thrice weekly 12 weeks home. At...
Abstract Guillain‐Barré syndrome (GBS) is an acute polyradiculoneuropathy with a highly variable clinical presentation, course, and outcome. The factors that determine the variation of GBS are poorly understood which complicates care treatment individual patients. protocol ongoing International Outcome Study (IGOS), prospective, observational, multicenter cohort study aims to identify biological determinants predictors disease onset, subtype, course outcome presented here. Patients...
To investigate the peripheral nerve and muscle function electrophysiologically in patients with persistent neuromuscular symptoms following Coronavirus disease 2019 (COVID-19).Twenty consecutive from a Long-term COVID-19 Clinic referred to electrophysiological examination suspicion of mono- or polyneuropathy were included. Examinations performed 77 255 (median: 216) days after acute COVID-19. None had received treatment at intensive care unit. Of these, 10 not even hospitalized. Conventional...
In the wake of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic, an increasing number patients with neurological disorders, including Guillain-Barré (GBS), have been reported following this infection. It remains unclear, however, if these cases are coincidental or not, as most publications were case reports small regional retrospective cohort studies. The International GBS Outcome Study is ongoing prospective observational study enrolling within weeks from onset...
<h3>Background and Objectives</h3> Infections play a key role in the development of Guillain-Barré syndrome (GBS) have been associated with specific clinical features disease severity. The variation GBS across geographical regions has suggested to be related differences distribution preceding infections, but this not studied on large scale. <h3>Methods</h3> We analyzed first 1,000 patients included International Outcome Study available biosamples (n = 768) for presence recent infection...
Abstract Guillain-Barré syndrome is an acute polyradiculoneuropathy in which preceding infections often elicit the production of antibodies that target peripheral nerve antigens, principally gangliosides. Anti-ganglioside are thought to play a key role clinical diversity disease and can be helpful practice. Extensive research into associations individual anti-ganglioside antibody specificities has been performed. Recent highlighted glycolipid complexes, combinations may alter binding, as...
<h3>Background:</h3> In multifocal motor neuropathy (MMN), high dose of IV immunoglobulin (IVIg) is the only established treatment. Subcutaneous self-infusion with G (IgG) (SCIG) increases patient autonomy and treatment flexibility, might be associated fewer side effects due to lower peak IgG levels. a recent study 9 patients MMN, we reported that SCIG preserves muscle strength for few months Five preferred continue after trial another chose apply SCIG. <h3>Methods:</h3> this case series 6...
<h3>Objective</h3> To define the current treatment practice of Guillain-Barré syndrome (GBS). <h3>Methods</h3> The study was based on prospective observational data from first 1,300 patients included in International GBS Outcome Study. We described general, and for (1) severe forms (unable to walk independently), (2) no recovery after initial treatment, (3) treatment-related fluctuations, (4) mild (able (5) variant including Miller Fisher syndrome, taking patient characteristics hospital...
To investigate CSF findings in relation to clinical and electrodiagnostic subtypes, severity, outcome of Guillain-Barré syndrome (GBS) based on 1,500 patients the International GBS Outcome Study.
To describe neurophysiological abnormalities in Long COVID and correlate quantitative electromyography (qEMG) single fiber EMG (sfEMG) results to clinical scores histopathology. 84 patients with non-improving musculoskeletal symptoms were examined qEMG sfEMG. Muscle biopsies taken a subgroup. Mean motor unit potential (MUP) duration was decreased ≥ 1 muscles 52 % of the patients. jitter increased 17 tibialis anterior 25 extensor digitorum communis. Increased seen or without myopathic qEMG....
Background and purpose Subcutaneous immunoglobulin ( SCIG ) is superior to placebo treatment for maintenance of muscle strength during 12 weeks in patients with chronic inflammatory demyelinating polyneuropathy CIDP ). The present study evaluated whether preserves 1 year an open‐label follow‐up study. Methods Seventeen responders intravenous IVIG who had participated the previous versus were included. After one infusion 2 prior baseline, all continued on at weekly equal dosage after 3, 6...
To compare disease course in patients with Guillain-Barré syndrome (GBS) a poor prognosis who were treated one or two intravenous immunoglobulin (IVIg) courses.From the International GBS Outcome Study, we selected whose modified Erasmus Score at week 1 predicted prognosis. We compared those IVIg to courses. The primary endpoint, disability scale 4 weeks, was assessed multivariable ordinal regression.Of 237 eligible patients, 199 received single course. Twenty an 'early' second (1-2 weeks...
<h3>Background and Objectives</h3> The clinical course outcome of the Guillain-Barré syndrome (GBS) are diverse vary among regions. modified Erasmus GBS Outcome Score (mEGOS), developed with data from Dutch patients, is a model that predicts risk walking inability in patients GBS. study objective was to validate mEGOS International Study (IGOS) cohort improve its performance region specificity. <h3>Methods</h3> We used prospective first 1,500 included IGOS, aged ≥6 years unable walk...
Abstract Background Current proposed criteria for functional cognitive disorder (FCD) have not been externally validated. We sought to analyse the current perspectives of specialists in diagnosis and management FCD comparison with neurodegenerative conditions. Methods International experts disorders were invited assess seven illustrative clinical vignettes containing history bedside characteristics alone. Participants assigned a probable selected appropriate investigation treatment....
Abstract Background and purpose Various electrodiagnostic criteria have been developed in Guillain–Barré syndrome (GBS). Their performance a broad representation of GBS patients has not evaluated. Motor conduction data from the International Outcome Study (IGOS) cohort were used to compare two widely criterion sets relate these diagnostic amyotrophic lateral sclerosis criteria. Methods From first 1500 IGOS, nerve studies 1137 (75.8%) available for current study. These classified according...
High dose intravenous immunoglobulin (IVIG) is an established treatment for various neuromuscular disorders. Recently, cases of hemolytic anemia following IVIG have been observed. The objective this study was to determine the extent and hemolysis after its relationship AB0 blood type system.In a prospective 34 de novo treated patients were given 2.0 g/kg bodyweight Privigen 50 received either [n = 28; 1.53 ± 0.4 (mean SD)] or Kiovig (n 22; 1.7 g/kg) as maintenance therapy. all had post-polio...