A5020389640- Dementia and Cognitive Impairment Research
- Neurology and Historical Studies
- Health Systems, Economic Evaluations, Quality of Life
- Alzheimer's disease research and treatments
- Epilepsy research and treatment
- Frailty in Older Adults
- Mental Health and Psychiatry
- Migraine and Headache Studies
- History of Medicine Studies
- Cerebrovascular and genetic disorders
- Neurological and metabolic disorders
- Parkinson's Disease Mechanisms and Treatments
- Genetic Neurodegenerative Diseases
- Psychosomatic Disorders and Their Treatments
- Neurological disorders and treatments
- Memory and Neural Mechanisms
- Neurological diseases and metabolism
- Neurobiology of Language and Bilingualism
- History of Medical Practice
- Genetics and Neurodevelopmental Disorders
- Prion Diseases and Protein Misfolding
- Pharmacological Effects and Toxicity Studies
- Functional Brain Connectivity Studies
- Ophthalmology and Eye Disorders
- Clinical practice guidelines implementation
University College London
1998-2025
Walton Centre
2016-2025
University of Liverpool
2016-2025
Royal London Hospital
2024
University of Lisbon
2024
GTx (United States)
2018
Monash University
2016
Eastern Health
2015-2016
National Health Service
2010-2014
Center Point
2014
ABSTRACT Background: This aim of this study was to assess the clinical utility Montreal Cognitive Assessment (MoCA) as a screening instrument for cognitive impairment in patients referred memory clinic, alone and combination with Mini-Mental State Examination (MMSE). Methods: pragmatic prospective consecutive referrals attending clinic (n = 150) over an 18-month period. Patients were diagnosed using standard diagnostic criteria dementia (DSM-IV) mild (MCI; prevalence 43%) independent MoCA...
The clinical syndromes of frontotemporal dementia are clinically and neuropathologically heterogeneous, but processes such as neuroinflammation may be common across the disease spectrum. We investigated how relates to localization tau TDP-43 pathology, heterogeneity disease. used PET in vivo with (i) 11C-PK-11195, a marker activated microglia proxy index neuroinflammation; (ii) 18F-AV-1451, radioligand increased binding pathologically affected regions tauopathies TDP-43-related disease,...
<i>Background/Aims:</i> To investigate the frequency of epilepsy at time diagnosis Alzheimer’s disease (AD). <i>Methods:</i> Observational study, Cognitive Function Clinic population, over a 6-year period (2000–2005 inclusive). <i>Results:</i> In cohort 177 patients with newly diagnosed clinically probable AD, 12 (6.8%) had history seizure disorder and/or were using anti-epileptic medications diagnosis. 6 these cases (3.4%), onset was approximately...
<h3>Background</h3> Voltage-gated potassium channel antibody-positive limbic encephalitis (VGKC+LE) frequently improves with immunotherapy, although the optimum regimen is unknown. The effectiveness of a combination immunomodulatory was tested in consecutive VGKC+LE patients. <h3>Methods</h3> This an open-label prospective study nine All patients had plasma exchange (50 ml/kg), intravenous immunoglobulin (2 g/kg) and methylprednisolone (1 g×3), followed by maintenance oral prednisolone...
Abstract Background Test Your Memory (TYM) test is a recently described cognitive instrument designed to be self‐administered under medical supervision. The pragmatic role of such tests in clinics has not previously been examined. We investigated the diagnostic utility TYM as an independent differentiate patients with and without dementia at initial clinical interview dedicated memory clinics. Methods was administered consecutive new patient referrals two other [Mini‐Mental State Examination...
Many cognitive screening instruments (CSI) are available to clinicians assess function. The optimal method comparing the diagnostic utility of such tests is uncertain. effect size (Cohen's d), calculated as difference means two groups divided by weighted pooled standard deviations these groups, may permit comparisons.Datasets from five pragmatic accuracy studies, which examined Mini-Mental State Examination (MMSE), Parkinson (MMP), Six-Item Cognitive Impairment Test (6CIT), Montreal...
Objectives Cognitive screening is recommended in stroke, but test completion may be complicated by stroke related impairments. We described feasibility of three commonly used cognitive tools and the effect on scoring properties when testing was entirely/partially incomplete. Methods performed a cross-sectional study, recruiting sequential patient admissions from two University Hospital rehabilitation services. assessed Folstein's mini-mental state examination (MMSE), Montreal assessment...
The six-item cognitive impairment test (6CIT) is a brief screening instrument (CSI) recommended for use in primary care settings. There are very few studies of 6CIT performance secondary settings.We undertook pragmatic diagnostic accuracy study consecutive patients referred over the course one year to neurology-led function clinic, and compared its diagnosis dementia mild (MCI) that simultaneously administered Mini-Mental State Examination (MMSE).In cohort 245 with prevalence around 20%,...
SummaryObservations are presented on nine selected patients with chronic upper limb demyelinating neuropathy to illustrate the range of manifestations that may be observed. In three, involvement was purely motor, in five, mixed motor and sensory and, one, virtually sensory; seven symptoms were unilateral two bilateral. The presence reduced nerve conduction velocity block response treatment cases indicate they represented examples inflammatory polyneuropathy (CIDP) focal involvement. This...