A5034515665- Psychosomatic Disorders and Their Treatments
- Dementia and Cognitive Impairment Research
- Neurological disorders and treatments
- Autoimmune Neurological Disorders and Treatments
- Neurobiology of Language and Bilingualism
- Long-Term Effects of COVID-19
- COVID-19 Clinical Research Studies
- Parkinson's Disease Mechanisms and Treatments
- Mental Health and Psychiatry
- Cancer Genomics and Diagnostics
- Otitis Media and Relapsing Polychondritis
- Vestibular and auditory disorders
- Body Image and Dysmorphia Studies
- Genetic factors in colorectal cancer
- Genetics and Neurodevelopmental Disorders
- Vasculitis and related conditions
- Multiple Sclerosis Research Studies
- Digital Mental Health Interventions
- Heavy Metal Exposure and Toxicity
- Maternal Mental Health During Pregnancy and Postpartum
- Alzheimer's disease research and treatments
- Delphi Technique in Research
- Hate Speech and Cyberbullying Detection
- Neuroscience, Education and Cognitive Function
- Sarcoidosis and Beryllium Toxicity Research
University of Edinburgh
2023-2025
Universidade do Porto
2018-2025
Hospital de São João
2018-2024
Edinburgh Royal Infirmary
2024
Instituto Português de Oncologia Francisco Gentil
2016-2017
IPO Porto
2016-2017
Abstract Background Current proposed criteria for functional cognitive disorder (FCD) have not been externally validated. We sought to analyse the current perspectives of specialists in diagnosis and management FCD comparison with neurodegenerative conditions. Methods International experts disorders were invited assess seven illustrative clinical vignettes containing history bedside characteristics alone. Participants assigned a probable selected appropriate investigation treatment....
Abstract Despite all the knowledge already gathered, picture of somatic genetic changes in colorectal tumorigenesis is far from complete. Recently, germline and mutations exonuclease domain polymerase epsilon, catalytic subunit ( POLE ) gene have been reported a small subset microsatellite‐stable hypermutated carcinomas CRC s), affecting proofreading activity enzyme leading to misincorporation bases during DNA replication. To evaluate role carcinogenesis, namely advanced , we searched for by...
Functional cognitive disorder (FCD) poses a diagnostic challenge due to its resemblance other neurocognitive disorders and limited biomarker accuracy. We aimed develop new checklist identify FCD versus disorders. The clinical was developed through mixed methods: (1) literature review, (2) three-round Delphi study with 45 clinicians from 12 countries (3) pilot discriminative accuracy in consecutive patients attending seven memory services across the UK. Items gathering consensus were...
The underlying mechanisms of functional cognitive disorder (FCD) are still poorly understood. This hinders diagnostic identification and establishment personalised effective treatments. We aimed to describe the precipitating factors for new-onset FCD explore differences between acute gradual onset groups. Retrospective analysis a consecutive sample patients seen in three dedicated clinics United Kingdom September 2023 March 2024. Only with at least one-year symptom duration were included....
<sec> <title>BACKGROUND</title> Functional cognitive disorder (FCD) is a common and disabling condition for which accessible evidence-based treatments are urgently needed. </sec> <title>OBJECTIVE</title> We describe the planning development stages of new self-help mobile app intervention FCD. <title>METHODS</title> The UK Medical Research Council's Complex Interventions framework was followed. Theory- user-centered approaches were adopted to develop Mementum – 6-week programme rooted on...
The recently published Alzheimer's Association Workgroup diagnostic criteria for Alzheimer disease and consensus-based workflows the use of biomarkers in neurocognitive disorders promote further normalization purely biological approaches to disorders. In this commentary, we reflect on dangers reductionist positions lacking solid scientific evidence proven cost-effectiveness benefits, particular its inability offer a meaningful formulation large number people with functional cognitive This,...
Functional neurological disorder (FND) is a common cause of disability. Despite recent advances in pathophysiological understanding and treatments, application this knowledge to clinical practice variable limited.
Abstract Cognitive symptoms are prevalent across neuropsychiatric disorders, increase distress and impair quality of life. Self-guided digital interventions offer accessibility, scalability, may overcome the research-to-practice treatment gap. Seventy-six trials with 5214 participants were identified. A random-effects meta-analysis investigated effects all self-guided interventions, compared to controls, at post-treatment. We found a small-to-moderate positive pooled effect on cognition ( k...
Primary Central Nervous System Vasculitis (PCNSV) is responsible for 3%-5% of strokes before age 50. It presents with clinical, radiological, and pathological variability. Optimal management unknown given the absence randomized clinical trials.Explore whether tocilizumab, an anti-interleukin-6 monoclonal antibody, effective treatment refractory PCNSV.Patients PCNSV treated tocilizumab in a single tertiary center were reviewed.Three patients identified. In two them, MRI-revealed ischemic...