A5034323610- COVID-19 Clinical Research Studies
- Long-Term Effects of COVID-19
- SARS-CoV-2 and COVID-19 Research
- Mosquito-borne diseases and control
- COVID-19 and healthcare impacts
- Infectious Encephalopathies and Encephalitis
- Viral Infections and Vectors
- Bacterial Infections and Vaccines
- Neuroinflammation and Neurodegeneration Mechanisms
- Antibiotic Use and Resistance
- COVID-19 and Mental Health
- Respiratory viral infections research
- COVID-19 Impact on Reproduction
- Retinal and Optic Conditions
- Sepsis Diagnosis and Treatment
- Disaster Response and Management
- Nosocomial Infections in ICU
- Respiratory Support and Mechanisms
- COVID-19 epidemiological studies
- Malaria Research and Control
- Bacillus and Francisella bacterial research
- Vagus Nerve Stimulation Research
- Genetic Associations and Epidemiology
- Amyotrophic Lateral Sclerosis Research
- Community Development and Social Impact
Health Protection Research Unit in Emerging and Zoonotic Infections at University of Liverpool
2020-2025
University of Liverpool
2018-2025
Clinical Trial Investigators
2025
St Mary's Hospital
2023
International Severe Acute Respiratory and Emerging Infection Consortium
2023
National Institute for Health Research
2020-2022
University of Edinburgh
2022
Centre for Inflammation Research
2022
The Queen's Medical Research Institute
2022
Salford Royal NHS Foundation Trust
2015
Background: The COVID-19 pandemic, caused by SARS-CoV-2, is of a scale not seen since the 1918 influenza pandemic. Although predominant clinical presentation with respiratory disease, neurological manifestations are being recognised increasingly. Based on knowledge other coronaviruses, especially those that SARS and MERS epidemics, we might expect to see rare cases central nervous system (CNS) peripheral (PNS) disease SARS-CoV-2.Recent developments: A growing number case reports series...
BackgroundSince 2015, the arthropod-borne viruses (arboviruses) Zika and chikungunya have spread across Americas causing outbreaks, accompanied by increases in immune-mediated infectious neurological disease. The spectrum of manifestations linked to these viruses, importance dual infection, are not known fully. We aimed investigate whether presentations differed according infecting arbovirus, patients with infection had a different disease or severity.MethodsWe report prospective...
Brain infections pose substantial challenges in diagnosis and management carry high mortality morbidity, especially low-income middle-income countries. We aimed to improve the early of patients admitted hospital (adults aged 16 years older children >28 days) with suspected acute brain at 13 hospitals Brazil, India, Malawi. With stakeholders, policy makers, patient public representatives, we co-designed a multifaceted clinical laboratory intervention, informed by an evaluation routine...
Aims Pathological heterogeneity within patients with frontotemporal lobar degeneration ( FTLD ) in general precludes the accurate assignment of diagnostic subtype life. The aim this study was to assess extent microglial cell activation order determine whether it might be possible employ as a marker vivo using PET ligand [11 C ]( R )‐ PK 11195 differentiate cases according histological subtype. Methods distribution and assessed semi‐quantitatively cortical grey subcortical white matter CD 68...
ObjectiveTo determine the clinical phenotype of Guillain-Barré syndrome (GBS) after Zika virus (ZIKV) infection, anti-glycolipid antibody signature, and role other circulating arthropod-borne viruses, we describe a cohort GBS patients identified during ZIKV chikungunya (CHIKV) outbreaks in Northeast Brazil.MethodsWe prospectively recruited from regional neurology center Brazil between December 2014 February 2017. Serum CSF were tested for ZIKV, CHIKV, dengue (DENV), by RT-PCR antibodies,...
We describe how COVID-19-related policy decisions and guidelines impacted healthcare workers (HCWs) during the UK’s first COVID-19 pandemic phase. Guidelines in aim to streamline processes, improve quality manage risk. However, we argue that this time studied often fell short of these goals practice. analysed 74 remote interviews with 14 UK HCWs over 6 months (February–August 2020). Reframing through Mol’s lens ‘enactment’, reveal embodied, relational material impacts some had for HCWs....
Determining the likelihood of causation by a pathogen in brain infections such asencephalitis and meningitis is challenging. While case definitions published forencephalitis for UK-based study 2010 have been used widely, there havebeen advances diagnostic methods clinical understanding since then, theywere not designed use globally nor patients with or abscess. Wepresent an update to these definitions, based on systematic review theliterature each pathogen, extend them include pathogens...
Abstract Background As COVID-19 death rates have risen and health-care systems experienced increased demand, national testing strategies come under scrutiny. Utilising qualitative interview data from a larger study, this paper provides insights into influences on the enactment of for health care workers (HCWs) in English NHS settings during wave one pandemic (March–August 2020). Through findings we aim to inform learning about policies practices; future diagnostic preparedness. Methods A...
<h3>Background/introduction</h3> We describe a case of 34 yr old Black African women fully suppressed on HAART for 9 yrs presenting with recurrent episodes HIV encephalopathy abnormal MRI brain scan and detectable in CSF. Following ARV switch her cognitive function scans had improved remains undetectable <h3>Aim(s)/objectives</h3> Started 2005 remained asymptomatic (Kivexa/Atvr/rit) CD4 > 500 mm. Presented initially 2014 to Neurology acute confusion, headaches convulsions. CSF revealed...
Background: Elderly people have largely been vaccinated against severe acute respiratory syndrome coronavirus 2 (SARSCoV-2) because of their higher risk disease 2019 (COVID-19). Little is known about the efficacy such vaccines in elderly with cerebrovascular diseases. Method: Here, we present preliminary results serology (IgA and IgG) molecular testing for SARS-CoV-2 a case series patients who were admitted an stroke had received single dose COVID-19 vaccine city northeastern Brazil....