A5026172339- Multiple Sclerosis Research Studies
- Peripheral Neuropathies and Disorders
- Genetic Neurodegenerative Diseases
- Neurological disorders and treatments
- Parkinson's Disease Mechanisms and Treatments
- Systemic Lupus Erythematosus Research
- Acute Myocardial Infarction Research
- Vestibular and auditory disorders
- Ophthalmology and Eye Disorders
- Neuroblastoma Research and Treatments
- Blood Pressure and Hypertension Studies
- Adrenal Hormones and Disorders
- Head and Neck Surgical Oncology
- Long-Term Effects of COVID-19
- Pituitary Gland Disorders and Treatments
- Airway Management and Intubation Techniques
- Neuroendocrine Tumor Research Advances
- Vasculitis and related conditions
- Cerebral Venous Sinus Thrombosis
- Cardiovascular Health and Disease Prevention
- Mitochondrial Function and Pathology
- Cardiac, Anesthesia and Surgical Outcomes
- Tracheal and airway disorders
- Sarcoidosis and Beryllium Toxicity Research
- Intraoperative Neuromonitoring and Anesthetic Effects
Hospital de São João
2015-2025
Universidade do Porto
2016-2025
Administração Regional de Saúde de Lisboa e Vale do Tejo
2024-2025
Mendeley (United Kingdom)
2025
University of Buenos Aires
2025
Hospitais da Universidade de Coimbra
2007-2024
Hospital de Santo António
2014-2024
Universidade de Uberaba
2024
Hospital Universitario La Paz
2023
University of Coimbra
2022
In Multiple Sclerosis (MS) prevalence studies of community and clinical samples, indicate that 45–60% patients are cognitively impaired. These cognitive dysfunctions have been traditionally described as heterogeneous, but more recent suggest there is a specific pattern MS-related dysfunctions. With the advent disease-modifying medications for MS emphasis on early intervention treatment, detection impairment at its earliest stage becomes particularly important. this review authors address:...
Anti-CD20 monoclonal antibodies are a class of immunosuppressive drugs widely used in the treatment central nervous system (CNS) inflammatory diseases, with well-established efficacy and safety. Although rare, these therapies can be associated serious adverse events including hematological infectious complications. This study aims to evaluate their safety tolerability profile real-world clinical practice. We conducted retrospective cohort comprising patients diagnosed multiple sclerosis (MS)...
Objective The objective of this study was to report the identification antibodies against glutamate kainate receptor subunit 2 (GluK2‐abs) in patients with autoimmune encephalitis, and describe clinical‐immunological features antibody effects. Methods Two sera from 8 similar rat brain immunostaining were used precipitate antigen neuronal cultures. A cell‐based assay (CBA) GluK2‐expressing HEK293 cells assess 596 different neurological disorders, 23 healthy controls. GluK2‐ab effects...
Background Spectral-domain optical coherence tomography has been used in several neurological conditions, and peripapillary macular measurements have proposed as potential biomarkers these disorders. The aim of this study was to investigate retinal choroidal changes Huntington's disease evaluate any correlation with the stage disease. Methods A cross-sectional observational compared patients controls. Patients were evaluated using Unified Disease Rating Scale. enhanced depth imaging used,...
The descriptions of early axonal damage in patients with multiple sclerosis (MS) prompted the search body fluid markers. However, studies addressing this issue MS present conflicting results.To assess levels tau protein definite MS.Cerebrospinal (CSF) samples from 50 diagnosis (33 F, 17 M; mean age: 33.6 years) and 19 age-matched individuals without organic neurological diseases (11 8 M), entered study. With regard to clinical course, were classified as follows: 32 relapsing-remitting (RR);...
Abstract Dementia is a major public health concern due to its increasing prevalence, substantial caregiver burden, and high financial costs. Currently, the anti-dementia drugs aim only at symptomatic effect. The subject of prescribing these in advanced stages matter considerable debate, with different countries making distinct recommendations. In this review article, we analyzed evidence regarding cognitive functional outcomes, adverse events, health-related costs, burden patients Alzheimer...
Os procedimentos estéticos vêm ocupando um grande lugar na odontologia, sendo o clareamento dental tratamento de escolha para os pacientes, devido à sua abordagem minimamente invasiva e com baixo custo, comparado a outros procedimentos. Normalmente, profissionais optam por géis clareadores peróxido hidrogênio como agente ativo, causa da eficácia. No entanto, quanto maior for concentração do gel, chance ocorrer efeitos adversos, sensibilidade ou irritação gengival. Assim, objetivo estudo é...
The incidence of multiple sclerosis (MS) among older patients is increasing. Some these develop the disease after age 50 years, a condition known as late-onset MS (LOMS). This study aimed to characterize in (50-75 years-old) by comparing LOMS with adult-onset (AOMS). We retrospectively analyzed data from 230 aged 50-75 years who attended Portuguese tertiary referral center. included 189 AOMS 58 [54-63] (median [interquartile range]) and 41 67 [61-70] years. Females predominated both (70.7%)...
Abstract Objective: This study aimed to evaluate the immune cell populations in patients with acute myocardial infarction (AMI). Methods: The keyword “myocardial infarction” was searched Gene Expression Omnibus database, and only transcriptomes from peripheral blood studies of AMI within 12 h symptom onset were included. Patients without same database included control group. differential analysis expressed genes, enrichment metabolic pathways associated significant proportions absolute...
This paper presents the adaptation and translation of Multilingual Assessment Instrument for Narratives (MAIN) to European Portuguese, addressing need linguistically culturally relevant assessment tools in Portuguese-speaking contexts. Following an overview Portuguese its unique linguistic features, we examine key distinctions from Brazilian which MAIN had previously been adapted. We outline process, involved expert review ensure instrument reads naturally speakers resonates with familiar...
Progranulin (PGRN) mutations are associated with different clinical phenotypes, including frontotemporal lobar degeneration (FTLD), corticobasal syndrome (CBS) and Alzheimer's disease (AD). As all pathogenic PGRN identified so far cause through haploinsufficiency, determination of levels has been proposed as a reliable method to identify mutation carriers.To evaluate the accuracy peripheral in identification carriers detected thus our Portuguese cohort.Serum were measured 244 subjects (124...
It is controversial whether high salt intake directly associated with cardiovascular (CV) events and how far this relation independent of blood pressure (BP). As Portugal has higher consumption mortality by stroke than other European countries, we examined could predict the development CV in a hypertensive population.In longitudinal retrospective study cohort 608 adult treated patients 54.1±14.3 years age, BMI 29.3±8.3 kg/m, 56.3% women 17.1% diabetics, evaluate long-term prognostic...