A5113813002- Multiple Sclerosis Research Studies
- Peripheral Neuropathies and Disorders
- Systemic Sclerosis and Related Diseases
- Reproductive System and Pregnancy
- Neurological and metabolic disorders
- Pharmacological Effects and Toxicity Studies
- Myasthenia Gravis and Thymoma
- Endometriosis Research and Treatment
- Magnesium in Health and Disease
- Metabolism and Genetic Disorders
- Skin Diseases and Diabetes
- Biochemical Acid Research Studies
- Parkinson's Disease and Spinal Disorders
- Facial Nerve Paralysis Treatment and Research
- Migraine and Headache Studies
- Water-Energy-Food Nexus Studies
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Neurological Complications and Syndromes
- Wastewater Treatment and Reuse
- Effects of Environmental Stressors on Livestock
- Assisted Reproductive Technology and Twin Pregnancy
- Protein Tyrosine Phosphatases
- Thyroid and Parathyroid Surgery
- Acute Ischemic Stroke Management
- Alcoholism and Thiamine Deficiency
University of Coimbra
2023
Hospitais da Universidade de Coimbra
2023
Hospital Braga
2011-2022
Centro Hospitalar do Porto
2021
Centro Hospitalar Tondela-Viseu
2020
John Radcliffe Hospital
2015
Hospital de São Marcos
2014-2015
Tohoku University
2015
University of Oxford
2015
Hospital de Santo António
2015
To investigate the association between neuromyelitis optica spectrum disorder (NMOSD) and pregnancy outcome.An international cohort of women with aquaporin-4 antibody-positive NMOSD ≥1 was studied retrospectively. Multivariate logistic regression used to whether after onset associated an increased risk miscarriage (cohort 40 women) or preeclampsia 57 women).Miscarriage rate higher in pregnancies (42.9% [95% confidence interval 17.7%-71.1%] vs. 7.04% [2.33%-15.7%]). Pregnancies conceived...
In this study we estimated the prevalence, incidence, and mortality of myasthenia gravis (MG) in northern Portugal characterized clinical features patients identified.We used 2 data sources: records from hospitals pyridostigmine prescription registers.On December 31, 2013, a point prevalence 111.7 per million population. The highest was observed group >65 years age, especially men (288.1 million). During an incidence rate 6.3 year. Among women, 15-49-year age group; men, increased with up to...
ObjectiveAnalyze the cases of posterior reversible encephalopathy syndrome (PRES) admitted in a Neurology Department during an 8-year period.MethodRetrospective observational study central hospital north Portugal.Results14 patients were identified, mean age 52.3 years. Precipitating factors included: eclampsia, isolated arterial hypertension, spinal trauma and autonomic dysreflexia, Guillain-Barré syndrome, sepsis, sarcoidosis pulmonary cryptococcosis drugs. Most presented...
Abstract Magnesium is the second most abundant intracellular cation, and involved in a multitude of cellular enzymatic reactions that are essential for life. Hypomagnesemia has been associated with various neurological symptoms. We report an intriguing case 68‐year‐old woman hypomagnesemia cerebellar syndrome transient lesion vermis selectively involving nodulus. Immediate replacement magnesium determined reversibility clinical picture.
It was suggested that intravenous thrombolysis (IT) leads to larger extent recanalization in cardioembolic stroke. In this work we assess if has beneficial clinical traduction.We evaluated 177 patients undergoing IT, which were categorized into (CE) and non-cardioembolic (NCE). National Institutes of Health Stroke Scale (NIHSS) modified Rankin scale compared.The mean age 67.4 ± 12.01 53.8% male. The NIHSS was: 14 (admission), 9 (24 h) 6 (discharge), similar subgroups. difference between at...
Alfentanil is used for chronic pain relief in palliative care. However, there a dearth of data on its use. For this reason, decision was made to review the use alfentanil Retrospective study carried out care service. The files patients who received as an intravenous or subcutaneous continuous infusion relief, between January 2018 and April 2019. In total, 111 113 admissions. Of them, 56 were male, median age 70 years. number days 6 (range 1 129). most frequent primary reasons switching...
Calcinosis cutis is a rare and potentially disabling condition characterized by calcium deposition in soft tissues. When associated with autoimmune connective tissue diseases, calcinosis classified as Dystrophic Cutis (DCC), being its occurrence systemic lupus erythematosus (SLE) patients fairly uncommon. We report case of DCC 49 years old woman eleven evolution SLE that presented two history multiple painful skin lesions, some them ulcerated exhibiting chalky white-yellow floor, both hands,...
<h3>Objective</h3> Neuromyelitis Optica Spectrum Disorder (NMOSD) predominantly affects women and is often active during childbearing years. We investigated the association between NMOSD pregnancy outcome. <h3>Methods</h3> Multivariate logistic regression was used to investigate whether pregnancies after onset were at an increased risk of miscarriage or preeclampsia in international cohort 60 with aquaporin-4 antibody-positive least one pregnancy. <h3>Results</h3> Miscarriage rates 12.9%...
OBJECTIVE: To investigate the association between neuromyelitis optica spectrum disorder (NMOSD) and pregnancy outcome. BACKGROUND: NMOSD is a chronic severe recurrent antibody-mediated of central nervous system associated with aquaporin-4 antibodies (AQP4-IgG), which predominantly affects women. The mean age onset estimated at 37-45 years it often active during childbearing years. DESIGN/METHODS: An international cohort 60 women AQP4-IgG positive 蠅1 was studied retrospectively. Multivariate...
IntroductIonThe WHO estimates that in 50% of couples with infertility issues, the male factor isolated is found 30% cases and combination female factors 20%. [1]][3][4][5] In last decades, several studies have described a substantial decline sperm counts, namely one systematic review claimed decrease 50-60% (1973-2011). 3 fact, over 90% due to poor quality, low or these two concomitantly. 2 Various conditions can account for infertility, anatomical defects, genetic abnormalities, systemic...
A long-chain 3-hydroxyacyl-CoA dehydrogenase (LCHAD) deficiency constitutes a very rare autosomal recessive disease, affecting long fatty acids’ metabolism. In the prenatal period, it is difficult to suspect this diagnosis in absence of family history, as there are no specific sonographic signs disease. 32-year-old pregnant woman was receiving follow-up care, she carrier for Duchenne muscular dystrophy (DMD). The fetus female, and pregnancy progressed normally until 29th week gestation. At...
Abstract The Ramsay Hunt's syndrome (RHS), caused by the reactivation of varicella-zoster virus (VZV), is an infrequent cause peripheral facial palsy in pediatric patients. A 16-year-old adolescent boy presented with headache, right earache, and signs lower motor neuron type palsy. He was medicated deflazacort. Four days later, he developed blurry vision eye, gait imbalance, vesicular lesions ear decreased ipsilateral hearing acuity. diagnosis RHS considered. Cerebrospinal fluid (CSF)...