A5058867677- Multiple Sclerosis Research Studies
- Peripheral Neuropathies and Disorders
- Myasthenia Gravis and Thymoma
- Autoimmune Neurological Disorders and Treatments
- Systemic Lupus Erythematosus Research
- Ocular Diseases and Behçet’s Syndrome
- Cerebral Venous Sinus Thrombosis
- Retinal and Optic Conditions
- Long-Term Effects of COVID-19
- Neuroinflammation and Neurodegeneration Mechanisms
- Sarcoidosis and Beryllium Toxicity Research
- Genetic Neurodegenerative Diseases
- Pituitary Gland Disorders and Treatments
- Neurological disorders and treatments
- Rheumatoid Arthritis Research and Therapies
- Reproductive System and Pregnancy
- Systemic Sclerosis and Related Diseases
- Mitochondrial Function and Pathology
- Otitis Media and Relapsing Polychondritis
- T-cell and B-cell Immunology
- Parkinson's Disease and Spinal Disorders
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Vasculitis and related conditions
- Thyroid and Parathyroid Surgery
- Ophthalmology and Eye Disorders
Hospital de Santo António
2014-2025
Universidade do Porto
2016-2025
Universidade Federal da Bahia
2025
UNIFAVIP
2025
Universidade Federal do Rio Grande do Norte
2025
Institute of Biomedical Science
2024
National University Health System
2024
Universidade Estadual da Paraíba
2024
Administração Regional de Saúde de Lisboa e Vale do Tejo
2024
Centro Hospitalar do Porto
2014-2023
Objective: To describe 16 patients with a coincidence of 2 rare diseases: aquaporin-4 antibody (AQP4-Ab)–mediated neuromyelitis optica spectrum disorder (AQP4-NMOSD) and acetylcholine receptor (AChR-Ab)–mediated myasthenia gravis (AChR-MG). Methods: The clinical details results AChR-MG AQP4-NMOSD were analyzed retrospectively. Results: All had early-onset AChR-MG, the majority mild generalized disease, high proportion achieved remission. Fifteen female; 11 Caucasian. In 14/16, MG preceded...
<h3>Objective:</h3> To investigate the influence of pregnancy on patients with neuromyelitis optica spectrum disorder (NMOSD). <h3>Methods:</h3> A total 190 women NMOSD were enrolled from 7 referral hospitals in 4 countries. We reviewed medical records and used a structured questionnaire to gravidity, parity, number relapses during 2 years before pregnancy, each trimester first second trimesters after delivery, for 6 months thereafter. The annualized relapse rate (ARR) was calculated period....
To investigate the association between neuromyelitis optica spectrum disorder (NMOSD) and pregnancy outcome.An international cohort of women with aquaporin-4 antibody-positive NMOSD ≥1 was studied retrospectively. Multivariate logistic regression used to whether after onset associated an increased risk miscarriage (cohort 40 women) or preeclampsia 57 women).Miscarriage rate higher in pregnancies (42.9% [95% confidence interval 17.7%-71.1%] vs. 7.04% [2.33%-15.7%]). Pregnancies conceived...
Recent data suggest that cognitive reserve modulates the adverse effects of multiple sclerosis (MS) pathology on functioning; however, protective education in MS are still unclear.To explore as an indicator reserve, while controlling for demographic, clinical and genetic features.A total 419 patients 159 healthy comparison (HC) subjects underwent a comprehensive neuropsychological (NP) assessment, answered Hospital Anxiety Depression Scale. Based HC data, patients' NP scores were adjusted...
Autoimmune diseases (AIDs) are characterized by a multifactorial aetiology and complex genetic background, with the MHC region playing major role. We genotyped for HLA-DRB1 locus 1228 patients AIDs-213 Systemic Lupus Erythematosus (SLE), 166 Psoriasis or Psoriatic Arthritis (Ps + PsA), 153 Rheumatoid (RA), 67 Sclerosis (SSc), 536 Multiple (MS), 93 Myasthenia Gravis (MG) 282 unrelated controls. confirmed previously established associations of HLA-DRB1(∗)15 (OR = 2.17) HLA-DRB1(∗)03 1.81)...
Multiple sclerosis (MS) is a long-lasting disabling disease with psychological implications. Hospital Anxiety and Depression Scale (HADS) questionnaire developed to screen anxiety depression among patients in hospital settings. The objective of this report was study the metric properties Portuguese version HADS regarding MS.This cross-sectional study. Three hundred eighty individuals diagnosis MS, according revised McDonald criteria, were recruited from an outpatient Neuroimmunology Clinic...
Objective To develop and validate the evidence-based consensus-based Behçet’s Syndrome Overall Damage Index (BODI). Methods Starting from 120 literature-retrieved preliminary items, BODI underwent multiple Delphi rounds with an international multidisciplinary panel consisting of rheumatologists, internists, ophthalmologists, neurologists, patient delegates until consensus was reached on final content. The validated in a cross-sectional multicentre cohort 228 patients syndrome (BS) through...
Abstract Background Myasthenia gravis (MG) is a rare autoimmune disorder. Several new treatment concepts have emerged in recent years, but access to these treatments varies due differing national reimbursement regulations, leading disparities across Europe. This highlights the need for high-quality data collection by stakeholders establish MG registries. A European registry could help bridge gap different countries, offering critical support regulatory decisions, foster international...
<h3>Background</h3> Neurological involvement in sarcoidosis is serious and often aggressive. Many patients respond to steroids but some show a progressive course despite treatment with even more potent immunosuppressive drugs. <h3>Objective</h3> The aim of this study was describe our experience the refractory neurosarcoidosis Infliximab—its effect on disease side effects. <h3>Methods</h3> A series four are reported combined various drugs whom Infliximab used. <h3>Results</h3> good response,...
Objective: The Brief Smell Identification Test (B-SIT) was used to explore odour identification capacities in multiple sclerosis (MS). Methods: In total, 153 consecutive patients with MS and 165 healthy controls (HC) participated the study. All participants were asked answer B-SIT Hospital Anxiety Depression Scale (HADS). Expanded Disability Status (EDSS), Multiple Sclerosis Severity (MSSS), Mini-Mental State Examination (MMSE) for patients’ clinical cognitive characterization. Results:...
In this study we estimated the prevalence, incidence, and mortality of myasthenia gravis (MG) in northern Portugal characterized clinical features patients identified.We used 2 data sources: records from hospitals pyridostigmine prescription registers.On December 31, 2013, a point prevalence 111.7 per million population. The highest was observed group >65 years age, especially men (288.1 million). During an incidence rate 6.3 year. Among women, 15-49-year age group; men, increased with up to...
To analyze the effects of pregnancy on neuromyelitis optica spectrum disorder (NMOSD) according to patients' serostatus and immunosuppressive therapy (IST).We performed a retrospective multicenter international study patients with NMOSD. Patients were tested for aquaporin-4 (AQP4) myelin oligodendrocyte glycoprotein (MOG) antibodies (Ab). Informative pregnancies reported when NMOSD onset occurred before or during up 12 months postpartum. The mean annualized relapse rate (ARR) was calculated...
Myasthenia gravis is an autoimmune neuromuscular disease, usually affecting women in the second and third decades. The course unpredictable during pregnancy puerperium. can cause major interference labour partum exacerbations of disease frequently occur. aim this series cases to analyse retrospectively anaesthetic management myasthenia patients complications peripartum period.Retrospective, single centre study from clinical files female who delivered between 1985 2007 at Hospital de Santo...
The Face-Name Associative Memory Exam (FNAME) is a paired associative memory test created to detect deficits in individuals with preclinical Alzheimer's disease (AD). Worse performance on FNAME cognitively healthy were found related higher amyloid beta (Aβ) burden measured Positron-Emission-Tomography using 11C-PiB (PiB-PET). We previously reported normative data of Spanish version (S-FNAME) Spanish-speaking subjects. aim the present study was determine whether S-FNAME associated Aβ...
The impact of Behçet's disease on higher cognitive functions is still poorly understood. We proposed (1) to characterize the neuropsychological profile patients with (Neuro‐BD) and without (BD) neurological manifestations; (2) identify which clinical, psychopathological, genetic variables are related performance; (3) explore association between functioning neuroimaging findings in BD patients. Fifteen Neuro‐BD 35 nonactive phase their illness underwent a examination, performed comprehensive...
Introduction: We evaluated the clinical course during pregnancy and neonatal outcomes of a cohort Portuguese women with myasthenia gravis (MG). Methods: Retrospective study. Results: Twenty-five patients 30 pregnancies were included. Mean maternal age was 32.4 ± 4.1 years. Miscarriage rate 6.7%, delivery 28 newborns. Deterioration in MG occurred 43.3%, 46.4% at postpartum. Eighty percent medicated pyridostigmine, 43.3% corticosteroids, 40% intravenous immunoglobulin. There no or deaths....
Background: Anti-titin antibodies have been previously associated with thymoma-associated myasthenia gravis (MG) and a more clinically severe form of MG. While currently only serving as disease biomarker, its possible utility an indicator underlying thymus malignancy may be value in clinical practice. Methods: Data was retrospectively collected analyzed from 2013 to 2022 using institutional record MG patients. were assessed Line Blot immunoassay. Results: From 130 cases, 32 (24.6%)...