Fátima Farinha
A5068559487- Systemic Lupus Erythematosus Research
- Salivary Gland Disorders and Functions
- Immunodeficiency and Autoimmune Disorders
- T-cell and B-cell Immunology
- Ocular Diseases and Behçet’s Syndrome
- Systemic Sclerosis and Related Diseases
- Monoclonal and Polyclonal Antibodies Research
- Atherosclerosis and Cardiovascular Diseases
- Immune Cell Function and Interaction
- Blood disorders and treatments
- Pregnancy and Medication Impact
- Fungal Infections and Studies
- Vasculitis and related conditions
- Polyomavirus and related diseases
- Eosinophilic Disorders and Syndromes
- Reproductive System and Pregnancy
- Restraint-Related Deaths
- Multiple Sclerosis Research Studies
- Chronic Lymphocytic Leukemia Research
- Infectious Diseases and Tuberculosis
- Liver Diseases and Immunity
- Cytomegalovirus and herpesvirus research
- Mycobacterium research and diagnosis
- Actinomycetales infections and treatment
- Protein Tyrosine Phosphatases
Institute of Biomedical Science
2024
Universidade do Porto
2015-2024
United Nations Industrial Development Organization
2024
University College London
2024
Centro Hospitalar do Porto
2014-2024
Center for Rheumatology
2024
Karolinska Institutet
2024
Hospital de Santo António
2001-2024
Instituto Politécnico de Santarém
2024
Karolinska University Hospital
2024
Clinical heterogeneity, a hallmark of systemic autoimmune diseases, impedes early diagnosis and effective treatment, issues that may be addressed if patients could classified into groups defined by molecular pattern. This study was undertaken to identify clusters for reclassifying diseases independently clinical diagnosis.Unsupervised clustering integrated whole blood transcriptome methylome cross-sectional data on 955 with 7 267 healthy controls undertaken. In addition, an inception cohort...
There is currently no approved treatment for primary Sjögren's syndrome, a disease that primarily affects adult women. The difficulty in developing effective therapies -in part- because of the heterogeneity clinical manifestation and pathophysiology disease. Finding common molecular signatures among patient subgroups could improve our understanding etiology, facilitate development targeted therapeutics. Here, we report, cross-sectional cohort, classification scheme syndrome patients based on...
Systemic lupus erythematosus (SLE) is a chronic autoimmune disease of unknown origin, in which both genetic and environmental factors are involved. One such factor vitamin D, vital hormone that plays specific function the immune system homeostasis, acting through nuclear receptor (VDR) expressed all cells. Several polymorphisms gene encodes this have been described. Though inconsistently, these associated with clinical manifestations SLE development.The aim study was to determine possible...
Autoimmune diseases (AIDs) are characterized by a multifactorial aetiology and complex genetic background, with the MHC region playing major role. We genotyped for HLA-DRB1 locus 1228 patients AIDs-213 Systemic Lupus Erythematosus (SLE), 166 Psoriasis or Psoriatic Arthritis (Ps + PsA), 153 Rheumatoid (RA), 67 Sclerosis (SSc), 536 Multiple (MS), 93 Myasthenia Gravis (MG) 282 unrelated controls. confirmed previously established associations of HLA-DRB1(∗)15 (OR = 2.17) HLA-DRB1(∗)03 1.81)...
IntroductionCurrent therapeutic management of lupus nephritis (LN) fails to induce long-term remission in over 50% patients, highlighting the urgent need for additional options.MethodsWe analysed differentially expressed genes peripheral blood from active LN (n=41) and non-renal (n=62) patients versus healthy controls (n=497) European PRECISESADS project (NTC02890121), dysregulated gene modules a discovery (n=26) replication (n=15) set cases.ResultsReplicated qualified correlation analyses...
Abstract One of the most challenging objective for clinical cytometry in prospective multicenter immunomonitoring trials is to compare frequencies, absolute numbers leukocyte populations and further mean fluorescence intensities cell markers, especially when data are generated from different instruments. Here, we describe an innovative standardization workflow all carry out any large-scale, multicentric flow analysis whatever duration, number or type instruments required realization such projects.
Systemic lupus erythematosus (SLE) is a life-threatening disorder that affects women at reproductive age. We evaluate the clinical impact of pregnancy in cohort Portuguese SLE patients and risk factors associated with maternal fetal adverse outcomes.A retrospective observational study included all pregnant managed tertiary hospital, between January 1993 December 2019. Baseline information was collected, maternal-fetal neonatal outcomes were evaluated. Disease activity before during...
Abstract Primary Sjögren’s syndrome (SS) is a systemic autoimmune disease characterized by lymphocytic infiltration and damage of exocrine salivary lacrimal glands. The etiology SS complex with environmental triggers genetic factors involved. By conducting an integrated multi-omics study, we confirmed vast coordinated hypomethylation overexpression effects in IFN-related genes, what known as the IFN signature. Stratified conditional analyses suggest strong interaction between SS-associated...
Anti-Ro autoantibodies are among the most frequently detected extractable nuclear antigen autoantibodies, mainly associated with primary Sjögren's syndrome (SS), systemic lupus erythematosus (SLE), and undifferentiated connective tissue disease (UCTD). This study was undertaken to determine if there is a common signature for all patients expressing anti-Ro 60 regardless of their phenotype.
Hemophagocytic syndrome is an unusual but fatal disorder characterized by pancytopenia and activation of macrophages. We describe one case acute systemic lupus erythematosus with presentation hemophagocytic not related to infection. The patient presented increasing activity histiocytes in the bone marrow. Concomitant class IV World Health Organization nephritis, serositis, high titer antinuclear factor positive test for anti-DNA antibody fitted diagnostic criteria erythematosus. She also...
Eosinophilic fasciitis (EF) was described in 1974 by Shulman as a rare fibrosing connective tissue disease of unknown etiology. An undetermined trigger is thought to lead the degranulation eosinophils that interact with fibroblasts and express fibrogenic cytokines including transforming factor tumor growth b interleukins 1 6. The purpose this study summarize seven cases EF central hospital.This retrospective descriptive population hospital. All patients diagnosed hospital unit were admitted...
Systemic lupus erythematosus (SLE) is a clinically heterogeneous disease translating the different genetic and environmental factors involved. Polymorphisms at several loci, including major histocompatibility complex (MHC), have been associated worldwide with SLE, although inconsistencies exist among these studies mainly due to heterogeneity between populations sample characteristics. The aim of present study was investigate in Portuguese SLE association HLA‐DRB1 alleles clinical patterns...
Summary Systemic lupus erythematosus ( SLE ) is a prototypical autoimmune disease with strong genetic and environmental components. Previous studies have shown increased levels of several chemokines in active . C‐C chemokine receptor type 5 CCR 5) involved the recruitment inflammatory cells into tissues, mechanisms modulating expression function may interfere development, influencing clinical course disease. The aim this study was to evaluate possible association between 5∆32 base‐pair...
Abstract The heterogeneity of systemic lupus erythematosus (SLE) can be explained by epigenetic alterations that disrupt transcriptional programs mediating environmental and genetic risk. This study evaluated the contribution to SLE considering molecular serological subtypes, genetics status, followed drug target discovery. We performed a stratified epigenome-wide association studies whole blood DNA methylation from 213 patients 221 controls. Methylation quantitative trait loci analyses,...