A5015629505- Systemic Lupus Erythematosus Research
- Rheumatoid Arthritis Research and Therapies
- Monoclonal and Polyclonal Antibodies Research
- T-cell and B-cell Immunology
- Systemic Sclerosis and Related Diseases
- Ocular Surface and Contact Lens
- Spondyloarthritis Studies and Treatments
- Salivary Gland Disorders and Functions
- Immunotherapy and Immune Responses
- Atherosclerosis and Cardiovascular Diseases
- Immune Cell Function and Interaction
- Tryptophan and brain disorders
- Autoimmune and Inflammatory Disorders Research
- Galectins and Cancer Biology
- Psoriasis: Treatment and Pathogenesis
- Renal Diseases and Glomerulopathies
- Immune Response and Inflammation
- Immunodeficiency and Autoimmune Disorders
- Protease and Inhibitor Mechanisms
- Pancreatitis Pathology and Treatment
- COVID-19 Clinical Research Studies
- SARS-CoV-2 and COVID-19 Research
- Blood Coagulation and Thrombosis Mechanisms
- Inflammasome and immune disorders
- Dermatology and Skin Diseases
University of Szeged
2016-2025
Center for Rheumatology
2024
Karolinska University Hospital
2024
Karolinska Institutet
2024
HUN-REN Szegedi Biológiai Kutatóközpont
2024
Institute of Genetics
2024
There is currently no approved treatment for primary Sjögren's syndrome, a disease that primarily affects adult women. The difficulty in developing effective therapies -in part- because of the heterogeneity clinical manifestation and pathophysiology disease. Finding common molecular signatures among patient subgroups could improve our understanding etiology, facilitate development targeted therapeutics. Here, we report, cross-sectional cohort, classification scheme syndrome patients based on...
Background/Objectives: Opioid consumption analysis in Hungary, particularly through ambulatory and hospital sales data, including regional information, is lacking. This study examines opioid use both sectors, explores variations, identifies influencing factors. Methods: A cross-sectional was conducted using data from care, quantifying defined daily doses (DDD) per 1000 inhabitants (DID) day, or DDD 100 patient days (DHPD) at national levels. Correlations between utilisation variables were...
Corneal Langerhans cells (LCs) offer the opportunity to gain insight into activity of innate immunity. We examined density and distribution LCs compared results with dry-eye parameters in rheumatoid arthritis (RA). Fifty-two RA patients various degrees disease 24 healthy subjects were enrolled. Peripheral central LC number morphology assessed vivo laser confocal microscopy. In addition, ocular surface index (OSDI), lid parallel conjunctival folds, Schirmer test, tear break-up time (TBUT)...
Purpose . Investigation of dry eye and corneal Langerhans cells (LCs) in systemic lupus erythematosus (SLE). Methods Prospective consecutive case series 27 SLE patients control subjects. Dry was evaluated by lid-parallel conjunctival folds (LIPCOF), Schirmer test, tear break-up time (TBUT), ocular surface disease index (OSDI) questionnaire. In vivo investigation LCs density morphology (LCM) performed with confocal microscopy (Heidelberg Retina Tomograph Rostock Cornea Module). Results Tear...
Data on the impact of biological therapies T-cell phenotype in rheumatoid arthritis are limited. Here, we prospectively measured percentages 15 circulating subtypes using flow cytometry. We obtained transversal and longitudinal data 30 anti-TNF responders, 19 secondary nonresponders, 43 IL-6R antagonist before, 8 weeks at least 6 months after therapy. Untreated RA patients healthy controls were also included. The important findings following: (1) proportion regulatory T-cells (Tregs) which...
Vaccine-induced immunity is essential for controlling the COVID-19 pandemic. Data on humoral and cellular immunogenicity safety of different SARS-CoV-2 vaccines in patients with autoimmune rheumatic musculoskeletal diseases (RMDs) are limited.A single center observational study evaluated two-dose regimen BBIBP-CorV inactivated, Gam-COVID-Vac AZD1222 adenovirus-based, BNT162b2 mRNA-1273 mRNA-based RMDs (n = 89) compared healthy controls 74). Neutralizing anti-RBD (receptor binding domain)...
IntroductionCurrent therapeutic management of lupus nephritis (LN) fails to induce long-term remission in over 50% patients, highlighting the urgent need for additional options.MethodsWe analysed differentially expressed genes peripheral blood from active LN (n=41) and non-renal (n=62) patients versus healthy controls (n=497) European PRECISESADS project (NTC02890121), dysregulated gene modules a discovery (n=26) replication (n=15) set cases.ResultsReplicated qualified correlation analyses...
APCs of the ocular surface, including corneal Langerhans cells (LCs), offer opportunity to gain insight into activity innate immunity. We examined LCs and dry eye parameters in ankylosing spondylitis (AS). Twenty-four AS patients with varying degrees disease 24 healthy participants were enrolled. Central peripheral LC numbers, cell morphology (LCM) assessed vivo laser confocal microscopy. In addition, surface index, lid parallel conjunctival folds, tear break up time, Schirmer test...
Purpose: The investigation of anti-inflammatory and immunosuppressive functions Kynurenic acid (KYNA) is now in focus. There also substantial evidence that TSG-6 has an activity. Therefore, the present study, we compared effects newly synthetized KYNA analogues on TNF-α production U-937 monocytic cells correlation with expression. Methods: was measured by ELISA, expression determined RTqPCR method. As cytokine inducers Staphylococcus aureus Chlamydia pneumoniae were used. Results: attenuated...
Objectives: Proinflammatory cytokines and heat shock proteins play fundamental roles in the pathogenesis of acute pancreatitis. We studied whether polymorphisms tumor necrosis factor α (TNF-α), protein 70-2 (HSP70-2), CD14 genes correlate with severity Methods: Patients pancreatitis (n = 77) mixed etiology were grouped according to disease on basis Ranson scores. Healthy blood donors 71) served as controls. TNF-α-308 polymorphism was determined by NcoI RFLP, HSP70-2 PstI CD14-159 melting...
The transient increase of the cytoplasmic free calcium level plays a key role in process lymphocyte activation. Kv1.3 and IKCa1 potassium channels are important regulators maintenance influx during activation present possible target for selective immunomodulation.Case-control study.We took peripheral blood samples from 10 healthy individuals 9 recently diagnosed rheumatoid arthritis (RA) patients receiving no anti-rheumatic treatment. We evaluated kinetics following CD4, Th1, Th2 CD8 cells...
Abstract Background: Soluble urokinase plasminogen activator receptor (suPAR) is a biomarker increasingly used for the assessment of systemic inflammation. We aimed to evaluate suPAR inflammatory activity in rheumatoid arthritis (RA) patients remission. Methods: In our cross-sectional study we measured plasma and C-reactive protein (CRP) levels as well erythrocyte sedimentation rate (ESR) 120 RA at various stages disease 29 healthy age-matched controls. Results: suPAR, CRP ESR values were...
Abstract One of the most challenging objective for clinical cytometry in prospective multicenter immunomonitoring trials is to compare frequencies, absolute numbers leukocyte populations and further mean fluorescence intensities cell markers, especially when data are generated from different instruments. Here, we describe an innovative standardization workflow all carry out any large-scale, multicentric flow analysis whatever duration, number or type instruments required realization such projects.
Disease-associated, differentially hypermethylated regions have been reported in rheumatoid arthritis (RA), but no DNA methyltransferase inhibitors evaluated either RA or any animal models of RA. The present study was conducted to evaluate the therapeutic potential 5'-azacytidine (5'-azaC), a inhibitor, and explore cellular gene regulatory networks involved context autoimmune arthritis.A disease-associated genome-wide methylation profile explored by methylated CpG island recovery...
Abstract Primary Sjögren’s syndrome (SS) is a systemic autoimmune disease characterized by lymphocytic infiltration and damage of exocrine salivary lacrimal glands. The etiology SS complex with environmental triggers genetic factors involved. By conducting an integrated multi-omics study, we confirmed vast coordinated hypomethylation overexpression effects in IFN-related genes, what known as the IFN signature. Stratified conditional analyses suggest strong interaction between SS-associated...
Anti-Ro autoantibodies are among the most frequently detected extractable nuclear antigen autoantibodies, mainly associated with primary Sjögren's syndrome (SS), systemic lupus erythematosus (SLE), and undifferentiated connective tissue disease (UCTD). This study was undertaken to determine if there is a common signature for all patients expressing anti-Ro 60 regardless of their phenotype.
<h3>Background:</h3> Patients (pts) with rheumatoid arthritis (RA) who have had inadequate response to or are intolerant of currently-available biologic targeted synthetic disease-modifying anti-rheumatic drugs (b/tsDMARDs) few treatment options and embody a crucial unmet need. Abiprubart (KPL-404) is humanized monoclonal IgG4 antibody stabilized/functionally-silent Fc region that binds CD40 inhibits the CD40/CD154 costimulatory interaction without lymphocyte depletion. was well-tolerated in...
Our aim was to assess the phenotype of T-cell subsets in patients with ankylosing spondylitis (AS), a chronic inflammatory rheumatic disease. In addition, we also tested short-term activation characteristics. Measurements were done 13 AS before and during intravenous therapy anti-TNF agent infliximab (IFX). Flow cytometry used determine peripheral blood their intracellular signaling activation. The prevalence Th2 Th17 cells responsible for regulation adaptive immunity higher than 9 healthy...
Objective: Soluble urokinase plasminogen activator receptor (suPAR) is a biomarker of systemic inflammation. We aimed to characterize plasma suPAR levels in SLE patients.Methods: measured suPAR, C reactive protein (CRP) and erythrocyte sedimentation rate (ESR) 89 patients 29 healthy controls.Results: ESR values were higher than controls, while CRP comparable. ROC analysis indicated cut-off value 5.70 ng/mL distinguish with high disease activity (SLEDAI >8).Conclusion: might be an objective...
Ankylosing spondylitis (AS) is a chronic, progressive immune-mediated inflammatory disease, driven primarily by Th1 and Th17 cells. Anti-TNF therapies are successfully used in AS to achieve maintain remission. However, their influence on the composition of T-cell subsets not clear. We aimed characterize changes repertoire after long-term anti-TNF treatment patients.Twenty-two patients under therapy were evaluated (15 responders 7 nonresponders). A wide range cell subtypes was analyzed with...
Objectives: Rheumatoid arthritis (RA) is a chronic, inflammatory joint disease with complex pathogenesis involving variety of immunological events. Recently, it has been suggested that kynurenic acid (KYNA) might be potential regulator processes in arthritis. KYNA definitive anti-inflammatory and immunosuppressive function. The aim the present study to investigate effects newly synthesized analog—SZR72 on vitro production tumor necrosis factor-α (TNF-α), factor-stimulated gene-6 (TSG-6),...