A5016585178- Neonatal Respiratory Health Research
- Birth, Development, and Health
- Reproductive System and Pregnancy
- Pregnancy and preeclampsia studies
- Immune Cell Function and Interaction
- Systemic Lupus Erythematosus Research
- Pregnancy and Medication Impact
- Iron Metabolism and Disorders
- T-cell and B-cell Immunology
- Asthma and respiratory diseases
- Infant Nutrition and Health
- Ion Transport and Channel Regulation
- Neonatal Health and Biochemistry
- Diabetes and associated disorders
- Celiac Disease Research and Management
- Eosinophilic Esophagitis
- Microscopic Colitis
- COVID-19 Clinical Research Studies
- Viral gastroenteritis research and epidemiology
- Immune Response and Inflammation
- Hormonal Regulation and Hypertension
- Rheumatoid Arthritis Research and Therapies
- Galectins and Cancer Biology
- Neonatal and fetal brain pathology
- Hormonal and reproductive studies
Semmelweis University
2016-2025
Hungarian Academy of Sciences
2009-2020
University of Debrecen
1926-2018
University of Miskolc
2018
Pázmány Péter Catholic University
2015
Institute for Literary Studies
2007-2010
Children's Hospital of Philadelphia
2000
University of Pennsylvania
1999
Heim Pál Gyermekkórház
1997
OBJECTIVES. Asphyxia and hypothermia may modify drug pharmacokinetics. We investigated whether analgesia with morphine in neonates hypoxic ischemic encephalopathy undergoing prolonged moderate systemic resulted elevated serum concentrations compared normothermic infants. PATIENTS AND METHODS. Infants from 1 center participating a multicenter randomized study of whole-body after perinatal asphyxia (the Total Body Hypothermia Study) were randomly selected for treatment (n = 10) or standard...
Citation Toldi G, Rigó J Jr, Stenczer B, Vásárhelyi Molvarec A. Increased prevalence of IL-17-producing peripheral blood lymphocytes in pre-eclampsia. Am Reprod Immunol 2011; 66: 223–229 Problem Systemic inflammation is a dominant component the pathogenesis Besides imbalance Th1 and Th2 cells, alterations Th17 regulatory T cells have also been suggested to contribute inflammation. We aimed describe these four CD4 lymphocyte subtypes pre-eclampsia normal pregnancy, along with that CD8 NK...
After months of restrictive containment efforts to fight the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) epidemic, European countries are planning reopen. To support process, we conducted a cross-sectional survey among Hungarian population estimate prevalence infectious cases and prior SARS-CoV-2 exposure. A representative sample (n = 17,787) for 14 years or older living in private households 8,283,810) was selected. The study performed within 16 days after 50 restrictions,...
Abstract Systemic inflammation is characteristic for preeclampsia (PE). A hypothesis immune dysregulation that the function of regulatory T cells (CD4 + FoxP3 , Tregs) inhibiting activation lymphocytes impaired. We investigated proportion Tregs and their cellular network in preeclamptic women. Fifteen 17 healthy pregnant women were enrolled 32nd gestational week (median age 29 (range 22–45) 32 26–38) years, respectively). PE was diagnosed according to international criteria at a median 30...
Problem Regulatory T cells ( regs) play an important role in the development of pregnancy‐specific immune tolerance. We aimed to determine peripheral frequency a recently described reg subpopulation, CD 4+ 25− F ox P 3+ subset, and its correlation with conventional 25high regs normal pregnancy NP ) pre‐eclampsia PE compared non‐pregnant (non‐ women. also examined proportion activated 3high subset within cells. Method took blood samples from 20 , 12 non‐P women determined above subsets using...
The dysregulation of adaptive immunity is extensively investigated in celiac disease (CD). Recent data also suggest, however, the implication innate CD. Toll-like receptors (TLRs) play a central role initiation or maintenance immune responses. aim this study was to characterise expression TLR2, TLR3, and TLR4 duodenal biopsy samples taken from children with CD controls.Duodenal specimens were collected 16 untreated CD, 9 treated 10 controls. mRNA determined by semiquantitative reverse...
Abstract Background Recent data suggest that gene expression profiles of peripheral white blood cells can reflect changes in the brain. We aimed to analyze transcriptome mononuclear (PBMC) and plasma metabolite levels migraineurs a self-controlled manner during between attacks. Methods Twenty-four patients with migraine were recruited samples collected headache-free (interictal) period headache (ictal) investigate disease- headache-specific alterations. Control from 13 age- sex-matched...
OBJECTIVE: Recent data have indicated the significance of vitamin D receptor (VDR) polymorphisms in type 1 diabetes mellitus (T1DM). We studied association five known restriction enzyme VDR gene patients with T1DM. DESIGN AND METHODS: One hundred and seven children T1DM (T1DM for 5 Years; age, 1-14 boys/girls, 57/50; body mass index, 17.0+/-2.3 kg/m(2); haemoglobin A(Ic) (HbA(Ic)), 7.87+/-1.05) 103 healthy subjects were enrolled. The ApaI, BsmI, FokI, TaqI Tru9I ("a", "b", "f", "t" "u"...
Several lines of evidence support the hypothesis that vascular endothelial growth factor (VEGF) plays an important role in pathogenesis pre-eclampsia (PE). VEGF is a key component regulation remodelling and survival cytotrophoblasts placenta. In this case–control study, we aimed to test whether genetic polymorphisms are associated with risk severe PE. We enrolled 84 nulliparous pregnant women PE (PE group). Their G+405C C–2578A genotypes were determined by PCR-restriction fragment length...
Even in developed countries the prevalence of subjects with suboptimal vitamin D levels is high. The aim this retrospective data analysis was to evaluate severe and moderate deficiencies (defined as <15 ng/ml 15–30 ng/ml, respectively) among patients evaluated at Semmelweis University during a period between April, 2009 March, 2010. Methods results: average level 5808 (3936 women 1872 men) 25.5 ± 10.9 ng/ml. deficiency whole population 72% 12%, respectively. Higher than normal were...
Abstract Background: Plasma iron is increased in preeclampsia (PE) when compared to healthy pregnant women. This contrast inflammation characteristic for PE. The link between homeostasis and hepcidin. Our goal was describe hepcidin concentrations its association with Methods: We obtained peripheral blood samples from 30 preeclamptic [gestational age: 36.5 (24–40) weeks] 37 women 36 (28–39) determine plasma interleukin-6 (IL-6) concentrations, complete cell counts parameters of [plasma iron,...
Asthma is a common chronic disease that may complicate pregnancy and risk factor for complications; however, immunological mechanisms of the bilateral interactions between asthma are not fully understood. Healthy gestation characterized by sensitive balance T(h)1/T(h)2/T(h)17/regulatory T (Treg) cells be altered in asthmatic pregnancy. The aim this study was to describe prevalence these cell subsets compared with healthy T(h)1, T(h)2, T(h)17 Treg lymphocytes identified surface intracellular...
The transient increase of the cytoplasmic free calcium level plays a key role in process lymphocyte activation. Kv1.3 and IKCa1 potassium channels are important regulators maintenance influx during activation present possible target for selective immunomodulation.Case-control study.We took peripheral blood samples from 10 healthy individuals 9 recently diagnosed rheumatoid arthritis (RA) patients receiving no anti-rheumatic treatment. We evaluated kinetics following CD4, Th1, Th2 CD8 cells...
Abstract Background: Soluble urokinase plasminogen activator receptor (suPAR) is a biomarker increasingly used for the assessment of systemic inflammation. We aimed to evaluate suPAR inflammatory activity in rheumatoid arthritis (RA) patients remission. Methods: In our cross-sectional study we measured plasma and C-reactive protein (CRP) levels as well erythrocyte sedimentation rate (ESR) 120 RA at various stages disease 29 healthy age-matched controls. Results: suPAR, CRP ESR values were...
There is no early, first-trimester risk estimation available to predict later (gestational week 24-28) gestational diabetes mellitus (GDM); however, it would be beneficial start an early treatment prevent the development of complications.We aimed identify prediction markers for GDM.The present case-control study based on cohort a Hungarian biobank containing biological samples and follow-up data from 2545 pregnant women. Oxidative-nitrative stress-related parameters, steroid hormone,...
Postischaemic acute renal failure (ARF) is influenced by sex. Na(+), K(+)-ATPase (NKA) plays a crucial role in the pathogenesis of postischaemic ARF. We tested impact sex on mRNA, protein expression, cellular distribution and enzyme activity NKA following ischaemia-reperfusion (I-R) injury. The left pedicle uninephrectomized female (F) male (M) Wistar rats was clamped for 55 min followed 2 h (T2) 16 (T16) reperfusion. Uninephrectomized, sham-operated F M served as controls (n= 6 per group)....