A5049064648- Rheumatoid Arthritis Research and Therapies
- Systemic Sclerosis and Related Diseases
- Allergic Rhinitis and Sensitization
- Immune Response and Inflammation
- Food Allergy and Anaphylaxis Research
- Dermatology and Skin Diseases
- NF-κB Signaling Pathways
- Macrophage Migration Inhibitory Factor
- Inflammatory mediators and NSAID effects
- Asthma and respiratory diseases
- Liver Disease Diagnosis and Treatment
- Immunodeficiency and Autoimmune Disorders
- Dermatologic Treatments and Research
- Viral Infections and Immunology Research
- Blood disorders and treatments
- Organ Transplantation Techniques and Outcomes
- Spondyloarthritis Studies and Treatments
- Signaling Pathways in Disease
- Mast cells and histamine
- Cystic Fibrosis Research Advances
- Systemic Lupus Erythematosus Research
- Liver physiology and pathology
- Platelet Disorders and Treatments
- Thermoregulation and physiological responses
- Orthopedic Infections and Treatments
University of Oxford
2017-2025
Allergy Therapeutics (United Kingdom)
2023-2024
Hammersmith Hospital
2020
Imperial College London
2020
Imperial College Healthcare NHS Trust
2020
Wellcome Trust
2020
The London College
2019
Sapienza University of Rome
2000-2011
Policlinico Umberto I
2011
Istituto Nazionale per la Fisica della Materia
2000
A modified grass allergen subcutaneous immunotherapy (SCIT) product with MicroCrystalline Tyrosine and monophosphoryl lipid-A as an adjuvant system (Grass MATA MPL [PQ Grass]) is being developed short-course treatment of grass-pollen allergic rhinitis (SAR) and/or rhinoconjunctivitis. We sought to evaluate the combined symptom medication score (CSMS) optimized cumulative dose 27,600 standardized units (SU) PQ Grass in a field setting prior embarking on pivotal Phase III trial.
Objective. To investigate capillary morphology and skin blood flow of dorsal hands by nailfold videocapillaroscopy (NVC) laser Doppler perfusion imaging (LDPI), respectively, in patients with primary Raynaud’s phenomenon (PRP) systemic sclerosis (SSc) to compare the results those obtained healthy controls. Methods. The study group consisted 142 SSc, 88 PRP, 147 NVC was performed all groups examined. In SSc capillaroscopic pattern classified as early, active, or late pattern. A baseline...
Objective. Our aim was to investigate effects of bosentan on hand perfusion in patients with systemic sclerosis (SSc) pulmonary arterial hypertension (PAH), using laser Doppler imaging (LDPI). Methods. We enrolled 30 SSc PAH, without and healthy controls. In controls at baseline, skin blood flow the dorsum hands determined a Lisca imager. The dorsal surface divided into 3 regions interest (ROI). ROI 1 included fingers from second fourth distally proximal interphalangeal finger joint. 2 area...
Tumour necrosis factor (TNF) is a potent inducer of endotoxin tolerance-associated molecules, such as interleukin-1 receptor-associated kinase 3 (IRAK3), and also therapeutic target in inflammatory autoimmune diseases, it upregulates the production mediators. The role IRAK3 was assessed rheumatoid arthritis (RA), disease which amenable to TNF blockade. As variant lacks death domain required for its canonical role, isoform expression determined different milieu by immunoblotting. RA synovial...
Abstract The organization of the hepatic microvascular network has been widely studied in recent years, especially with regard to cirrhosis. This research enabled us recognize distinctive vascular patterns cirrhotic liver, compared normal which may explain cause liver dysfunction and failure. aim this study was compare rat livers by means a quantitative mathematical approach based on fractal Fourier analyses performed photomicrographs therefore discriminant analysis. Vascular corrosion casts...
The mechanisms of endotoxin tolerance (ET), which down-regulate inflammation, are well described in response to exogenous toll-like receptor ligands, but few studies have focused on ET-associated inflammatory disease. As blocking TNF can attenuate the development ET, effect anti-TNF expression key molecules auto-immune disease was measured; changes gene were confirmed using an ET bioassay. immunomodulatory measured a murine model arthritis treated with and whole blood rheumatoid (RA)...
Expression of the translocator protein (TSPO) on inflammatory cells has facilitated imaging synovitis with TSPO-targeted positron emission tomography (PET). We aimed to quantitatively assess specificity second-generation TSPO PET radioligand, [11C]PBR28, and generate simplified protocols in patients joint disease (IJD) this pilot study.Three IJD (two rheumatoid arthritis one osteoarthritis) knee involvement underwent dynamic [11C]PBR28-PET scans before after administration 90 mg oral...
Psoriasis is a chronic inflammatory disease of the skin affecting 2-3% UK population. 30% people affected by psoriasis will develop distinct form arthritis within 10 years condition onset. Although pathogenesis psoriatic still unknown, there genetic predisposition triggered environmental factors. Limited but convincing evidence link gut microbiome to arthritis. The Microbiome in Psoriatic ARThritis (Mi-PART) study propose characterise microbiome-metabolic interface patients deepen our...