Matteo Piga
A5029683989- Systemic Lupus Erythematosus Research
- Rheumatoid Arthritis Research and Therapies
- Spondyloarthritis Studies and Treatments
- Systemic Sclerosis and Related Diseases
- Autoimmune and Inflammatory Disorders Research
- Fuel Cells and Related Materials
- Ocular Diseases and Behçet’s Syndrome
- Monoclonal and Polyclonal Antibodies Research
- Atherosclerosis and Cardiovascular Diseases
- Cytokine Signaling Pathways and Interactions
- Psoriasis: Treatment and Pathogenesis
- Peripheral Neuropathies and Disorders
- Otitis Media and Relapsing Polychondritis
- Vasculitis and related conditions
- Inflammasome and immune disorders
- Advanced Battery Technologies Research
- T-cell and B-cell Immunology
- Medical Imaging and Pathology Studies
- Liver Disease Diagnosis and Treatment
- Inflammatory Myopathies and Dermatomyositis
- Thyroid Disorders and Treatments
- Cerebrovascular and Carotid Artery Diseases
- Viral Infections and Immunology Research
- Advanced battery technologies research
- Conducting polymers and applications
University of Cagliari
2016-2025
Azienda Ospedaliero-Universitaria Cagliari
2012-2025
Policlinico San Matteo Fondazione
2024
Azienda Ospedaliera Citta' della Salute e della Scienza di Torino
2022
Istituti di Ricovero e Cura a Carattere Scientifico
2022
Policlinico Universitario di Catania
2006-2019
University of Molise
2015
University Dermatology
2015
University of Ferrara
2004-2014
Università Cattolica del Sacro Cuore
2014
Genomewide association studies of autoimmune diseases have mapped hundreds susceptibility regions in the genome. However, only for a few signals has causal gene been identified, and even fewer variant underlying mechanism defined. Coincident associations DNA variants affecting both risk disease quantitative immune variables provide an informative route to explore mechanisms drug-targetable pathways.Using case-control samples from Sardinia, Italy, we performed genomewide study multiple...
Antisynthetase syndrome (ASSD) is a rare clinical condition that characterized by the occurrence of classic triad, encompassing myositis, arthritis, and interstitial lung disease (ILD), along with specific autoantibodies are addressed to different aminoacyl tRNA synthetases (ARS). Until now, it has been unknown whether presence ARS might affect presentation, evolution, outcome ASSD. In this study, we retrospectively recorded time onset, characteristics, clustering triad findings, survival...
Systemic lupus erythematosus (SLE) presents with nonspecific signs and symptoms that are also found in other conditions. This study aimed to evaluate manifestations at disease onset compare early SLE those of diseases mimicking SLE.Academic centers Asia, Europe, North America, South America collected baseline data on patients who were referred them during the previous 3 years for possible had a symptom duration <1 year. Clinical serologic compared between diagnosed as having SLE-mimicking...
Background: Interleukin (IL)-1 plays a crucial role in the pathogenesis of Adult onset Still's disease (AOSD). Objectives: To evaluate efficacy and safety anakinra (ANA) canakinumab (CAN) large group AOSD patients. Methods: Data on clinical, serological features, concomitant treatments were retrospectively collected at baseline after 3, 6, 12 months from patients (Yamaguchi criteria) referred by 18 Italian centers. Pouchot's score was used to severity. Results: One hundred forty treated with...
To investigate predictors of response, remission, low disease activity, damage, and drug discontinuation in patients with systemic lupus erythematosus (SLE) who were treated belimumab.In this retrospective study a multicenter cohort SLE received intravenous belimumab, the proportion achieved treatment response according to Responder Index 4 (SRI-4) was determined, Systemic Lupus International Collaborating Clinics/American College Rheumatology Damage (SDI) used score damage yearly over...
131 vaccine candidates have been evaluated for SARS-CoV-2 in more than 380 trials, eventually leading to 20 approvals1McGill COVID-19 Vaccine Tracker TeamCOVID19 Tracker.https://covid19.trackvaccines.org/vaccines/Date accessed: May 27, 2021Google Scholar and 1·8 billion people vaccinated worldwide as of July 1, 2021. There is a paucity data regarding the safety vaccines patients with rheumatic musculoskeletal diseases2Geisen UM Berner DK Tran F et al.Immunogenicity anti-SARS-CoV-2 mRNA...
Objective To define the role of ultrasound (US) for assessment patients with rheumatoid arthritis (RA) in clinical remission, including joint and tendon evaluation. Methods A multicentre longitudinal study has been promoted by US Study Group Italian Society Rheumatology. 25 centres participated, enrolling consecutive RA remission. All underwent complete (demographic data, disease characteristics, laboratory exams, 28 joints patient/physician-reported outcomes) Power Doppler (PD) evaluation...
To assess, in spondyloarthritis (SpA), the discriminative value of Outcome Measures Rheumatology (OMERACT) ultrasound lesions enthesitis and their associations with clinical features this population.
VEXAS syndrome is a recently described monogenic autoinflammatory disease capable of manifesting itself with wide array organs and tissues involvement. Orbital/ocular inflammatory manifestations are frequently in patients. The objective this study to further describe orbital/ocular conditions while investigating potential associations other manifestations. In the present study, twenty-seven out 59 (45.8%) patients showed an involvement during their clinical history. most frequent affections...
VEXAS syndrome, a recently identified systemic autoinflammatory disorder, poses new diagnostic and management challenges. Based on experience with other diseases, anti-interleukin (IL)-1, anti-IL-6, anti-tumor necrosis factor (TNF) biotechnological agents, Janus kinase inhibitors (JAKis) have been widely employed in patients. The aim of this study is to evaluate the global effectiveness safety agents JAKis using data from real-world context. Clinical, laboratory, therapeutic patients were...
The aim of this study was to evaluate morphological and functional abnormalities by cerebral imaging in a series systemic lupus erythematosus (SLE) patients with without overt central nervous system (CNS) manifestations, detect possible relationships clinical parameters large panel autoantibodies, including those reactive against neurotypic gliotypic antigens. 68 SLE were investigated cross-sectional which included evaluation symptoms, magnetic resonance (MRI) brain single photon emission...
Objective. To analyse risk factors and comorbidities potentially associated with CNS involvement in a large cohort of Italian patients affected by SLE. Methods. A number generic (not strictly SLE related) specific (disease to which all have been exposed the span 5 years before first neuropsychiatric (NP) event or last available observation were checked for their distribution was analysed 959 without NP involvement; events that occurred time frame 10 recorded categorized as related unrelated....
To estimate the prevalence of, and identify factors associated with, hand wrist US alterations in a large cohort of SLE patients.One hundred eight consecutive patients were recruited classified according to arthropathy type musculoskeletal item British Isles Lupus Assessment Group (BILAG) 2004 score. examinations performed on flexor tendons, extensor second third MCP joints bilaterally using multi-planar scanning technique.US examination showed joint involvement 42/108 (38.8%) subjects,...
The thermal, mechanical, and electric properties of hybrid membranes based on Nafion that contain a [(ZrO(2))·(Ta(2)O(5))(0.119)] "core-shell" nanofiller are elucidated. DSC investigations reveal the presence four endothermic transitions between 50 300 °C. DMA results indicate improved mechanical stability materials. consistent with our previous suggestion dynamic R-SO(3)H···[ZrTa] cross-links in material. These increase thermal -SO(3)H groups temperature relaxation events occurring...
The aim was to assess the attainability and outcome of lupus low disease activity state (LLDAS) in early stages systemic erythematosus (SLE). LLDAS prevalence evaluated at 6 (T1) 18 (T2) months after diagnosis treatment initiation (T0) a monocentric cohort 107 (median duration 9.7 months) prospectively followed Caucasian patients with SLE. Reasons for failure achieve were also investigated. Multivariate models built identify factors associated lack achievement investigate relationship...