A5036482703- Nonlinear Partial Differential Equations
- Advanced Mathematical Modeling in Engineering
- Spondyloarthritis Studies and Treatments
- Differential Equations and Boundary Problems
- Numerical methods in inverse problems
- Rheumatoid Arthritis Research and Therapies
- Systemic Lupus Erythematosus Research
- Geometric Analysis and Curvature Flows
- Differential Equations and Numerical Methods
- Psoriasis: Treatment and Pathogenesis
- Systemic Sclerosis and Related Diseases
- Spectral Theory in Mathematical Physics
- Geometry and complex manifolds
- Analytic and geometric function theory
- Nonlinear Differential Equations Analysis
- Liver Disease Diagnosis and Treatment
- Optimization and Variational Analysis
- Numerical methods for differential equations
- Autoimmune and Inflammatory Disorders Research
- Functional Equations Stability Results
- Immune Cell Function and Interaction
- Liver Diseases and Immunity
- Advanced Numerical Methods in Computational Mathematics
- Hepatitis C virus research
- Contact Mechanics and Variational Inequalities
University of Cagliari
2014-2023
Kathmandu University
2014
MRC Human Immunology Unit
2013
University of Oxford
2013
John Radcliffe Hospital
2013
Sapienza University of Rome
2010
Istituto Nazionale di Fisica Nucleare, Sezione di Cagliari
2009
École Normale Supérieure - Marrakech
2006
Cadi Ayyad University
2006
Objective To develop new composite disease activity indices for psoriatic arthritis (PsA). Methods Data from routine clinic visits at multiple centres were collected in a systematic manner. included all domains identified as important randomised controlled trials PsA. Decisions to change treatment used surrogates high activity. New developed by linear regression (psoriatic score: PASDAS) and empirically, utilising physician-defined cut-offs (arithmetic mean of desirability functions: AMDF)....
Objective. During OMERACT 8, delegates selected patient global assessment (PGA) of disease as a domain to be evaluated in randomized controlled trials psoriatic arthritis (PsA). This study assessed the reliability PGA, measured by means 0–100 mm visual analog scale (VAS), and additional utility separate VAS scales for joints (PJA) skin (PSA). Methods. In total, 319 consecutive patients with PsA (186 men, 133 women, mean age 51 ± 13 yrs) were enrolled. PJA, PSA administered at enrolment (W0)...
Objective. To identify the clinical features that can help to distinguish between psoriatic arthritis (PsA) and fibromyalgia (FM). Methods. Our cross-sectional study was carried out in 10 Italian rheumatology centers January September 2009, enrolled all consecutive patients with PsA FM who agreed participate. Standard laboratory data for were collected from patients. Records made of somatic symptoms, response nonsteroidal antiinflammatory drugs (NSAID), self-evaluated pain, general health,...
To estimate the prevalence of, and identify factors associated with, hand wrist US alterations in a large cohort of SLE patients.One hundred eight consecutive patients were recruited classified according to arthropathy type musculoskeletal item British Isles Lupus Assessment Group (BILAG) 2004 score. examinations performed on flexor tendons, extensor second third MCP joints bilaterally using multi-planar scanning technique.US examination showed joint involvement 42/108 (38.8%) subjects,...
Objectives. HLA-B*27:05 is associated with AS whereas HLA-B*27:09 not associated. We hypothesized that different interactions KIR immune receptors could contribute to the difference in disease association between and HLAB*27:09. Thus, objective of this study was compare formation β2m-free heavy chain (FHC) including B27 dimers (B272) by their binding immunoreceptors.
TNF-alpha antagonists, infliximab (INF), etanercept (ETA) and adalimumab (ADA), have been demonstrated to be effective in controlling symptoms SpAs. The aim of this study was investigate the possibility using ADA as a second or third choice.A retrospective conducted patients with SpA treated blockers who switched from INF ETA ADA, for inefficacy adverse events. Kaplan-Meier survival curves were plotted determine rates continuation first treatment (INF ETA) compared ADA.A total 1619 (35.3%),...
This paper concerns minimization and maximization of the first eigenvalue in problems involving <inline-formula content-type="math/mathml"> <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" alttext="p"> <mml:semantics> <mml:mi>p</mml:mi> <mml:annotation encoding="application/x-tex">p</mml:annotation> </mml:semantics> </mml:math> </inline-formula>-Laplacian, under homogeneous Dirichlet boundary conditions. Physically, case alttext="upper N equals 2"> <mml:mrow> <mml:mi>N</mml:mi>...
Objective. Physician’s global assessment (PGA) of disease activity is a major determinant therapeutic decision making. This study assesses the reliability PGA, measured by means 0–100 mm visual analog scale (VAS), and additional use separate VAS scales for musculoskeletal (PhysMSK) dermatologic (PhysSk) manifestations in patients with psoriatic arthritis (PsA). Methods. Sixteen centers from 8 countries enrolled 319 consecutive PsA. PhysMSK, PhysSk evaluation forms were administered at...
Abstract We investigate the minimization of principal eigenvalue Laplacian under Neumann boundary conditions in case weight has indefinite sign and varies a class rearrangements. Biologically, this problem is motivated by question determining most convenient spatial arrangement favorable unfavorable resources for species to survive. The may have practical importance context reserve design. Keywords: Eigenvalue problemsOptimizationPopulation dynamicsRearrangementsSymmetry breakingAMS (2000)...
We investigate explosive solutions of the equation $\Delta u=f(u)$ in a bounded convex domain $D$. find some asymptotic estimates and prove log-convexity solution $u(x)$ under suitable conditions on $f$.
This paper concerns optimization problems related to bi-harmonic equations subject either Navier or Dirichlet homogeneous boundary conditions. Physically, in dimension two, our equation models the deformation of an elastic plate which is hinged clamped along boundary, under load. We discuss existence, uniqueness, and properties optimizers.
Objective: Previous reports have highlighted the relevance of HLA-B27 expression in pathogenesis ankylosing spondylitis (AS). The aim current study was to estimate level on cell surface ex vivo monocytes and lymphocytes by a quantitative method correlate this with AS disease susceptibility, clinical indexes, occurrence acute anterior uveitis (AAU).