A5054910144- Inflammatory Myopathies and Dermatomyositis
- Cannabis and Cannabinoid Research
- Global Health Care Issues
- Health and Medical Studies
- Healthcare Policy and Management
- Vasculitis and related conditions
- Eosinophilic Disorders and Syndromes
- Health Systems, Economic Evaluations, Quality of Life
- Neurotransmitter Receptor Influence on Behavior
- Retinal Diseases and Treatments
- Systemic Sclerosis and Related Diseases
- Systemic Lupus Erythematosus Research
- Neuroscience and Neuropharmacology Research
- Substance Abuse Treatment and Outcomes
- Muscle Physiology and Disorders
- Forensic Toxicology and Drug Analysis
- Obsessive-Compulsive Spectrum Disorders
- Retinal and Optic Conditions
- Rheumatoid Arthritis Research and Therapies
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Alcoholism and Thiamine Deficiency
- Health disparities and outcomes
- Retinal Imaging and Analysis
- Immunodeficiency and Autoimmune Disorders
- Orthopedic Infections and Treatments
Charité - Universitätsmedizin Berlin
2016-2025
Techniker Krankenkasse (Germany)
2011-2025
Humboldt-Universität zu Berlin
2000-2024
Freie Universität Berlin
1978-2024
Universität Hamburg
2005-2024
Tokai University
2024
Tokai University Hospital
2024
University Medical Center Hamburg-Eppendorf
2024
Ruhr University Bochum
2017-2023
Deutscher Wetterdienst
2019-2023
Abstract Objective To investigate the efficacy and tolerability of infliximab therapy for articular dermatologic manifestations active psoriatic arthritis (PsA). Methods One hundred four patients with PsA in whom prior at least 1 disease‐modifying antirheumatic drug (DMARD) had failed were recruited into this investigator‐initiated, multicenter, randomized, double‐blind, placebo‐controlled clinical trial. During initial blinded portion study, received infusions (5 mg/kg) or placebo weeks 0,...
Daratumumab, a human monoclonal antibody that targets CD38, depletes plasma cells and is approved for the treatment of multiple myeloma. Long-lived are implicated in pathogenesis systemic lupus erythematosus because they secrete autoantibodies, but unresponsive to standard immunosuppression. We describe use daratumumab induced substantial clinical responses two patients with life-threatening lupus, sustained by maintenance therapy belimumab, an B-cell activating factor. Significant depletion...
Antisynthetase syndrome (ASSD) is a rare clinical condition that characterized by the occurrence of classic triad, encompassing myositis, arthritis, and interstitial lung disease (ILD), along with specific autoantibodies are addressed to different aminoacyl tRNA synthetases (ARS). Until now, it has been unknown whether presence ARS might affect presentation, evolution, outcome ASSD. In this study, we retrospectively recorded time onset, characteristics, clustering triad findings, survival...
1',1'dimethylheptyl-Delta8-tetrahydrocannabinol-11-oic acid (CT-3), a potent analog of THC-11-oic acid, produces marked antiallodynic and analgesic effects in animals without evoking the typical described models cannabinoids. Therefore, CT-3 may be an effective for poorly controlled resistant neuropathic pain.To examine efficacy safety chronic pain humans.Randomized, placebo-controlled, double-blind crossover trial conducted Germany from May-September 2002.Twenty-one patients (8 women 13...
Background: We investigated (1) the prevalence of posttraumatic stress disorder (PTSD) in treatment‐seeking subjects with substance use dependence (SUD), (2) association between comorbid PTSD and severity course addiction psychopathology, (3) this patients subsyndromal PTSD, trauma exposure without PTSD. Methods: In cross‐sectional study, 459 14 German treatment centers participated alcohol‐dependence (A) 39.7%, drug‐dependence (D) 33.6%, or both (AD) 26.8%. The diagnostic measures included...
Article Abstract Background: Preliminary studies suggested that delta-9-tetrahydrocannabinol (THC), the major psychoactive ingredient of Cannabis sativa L., might be effective in treatment Tourette syndrome (TS). This study was performed to investigate for first time under controlled conditions, over a longer-term period, whether THC is and safe reducing tics TS. Method: In this randomized, double-blind, placebo-controlled study, 24 patients with TS, according DSM-III-R criteria, were...
Anecdotal reports in Tourette's syndrome (TS) have suggested that marijuana (cannabis sativa) and delta-9-tetrahydrocannabinol (Δ9-THC), the major psychoactive ingredient of marijuana, reduce tics associated behavioral disorders. We performed a randomized double-blind placebo-controlled crossover single-dose trial Δ9-THC (5.0, 7.5 or 10.0 mg) 12 adult TS patients. Tic severity was assessed using self-rating scale (Tourette's Symptom List, TSSL) examiner ratings (Shapiro Severity Scale, Yale...
Aims: Attention-deficit/hyperactivity disorder (ADHD) is of great clinical importance not only because its high prevalence but also due to the frequent comorbid illnesses that are connected with this disorder. Several studies were able demonstrate ADHD constitutes a significant risk factor for exacerbation habit-forming illnesses, i.e. addictions. Methods: We conducted study on 152 adult patients alcohol dependence (n = 91) or multiple substance addiction 61) determine whether these affected...
OBJECTIVE The aim of this study is to provide reliable regression-based estimates costs associated with different type 2 diabetes complications. RESEARCH DESIGN AND METHODS We used nationwide statutory health insurance (SHI) data from 316,220 patients diabetes. Costs for inpatient and outpatient care, pharmaceuticals, rehabilitation, nonmedical aids appliances were assessed in the years 2013–2015. Quarterly observations are available each year. estimated (in 2015 euro) complications using a...
To analyze antisynthetase syndrome-associated myositis by modern myopathologic methods and to define its place in the spectrum of idiopathic inflammatory myopathies (IIMs).Skeletal muscle biopsies from other IIMs different institutions worldwide were analyzed histopathology, quantitative PCR, electron microscopy.Myonuclear actin filament inclusions identified as a unique morphologic hallmark myositis. Nuclear never found dermatomyositis, polymyositis, sporadic inclusion body myositis,...
Significance Statement Early identification of patients at risk renal flares in ANCA vasculitis is crucial. However, current clinical parameters have limitations predicting relapse accurately. This study investigated the use urinary CD4 + T lymphocytes as a predictive biomarker for vasculitis. study, including urine samples from 102 patients, found that presence cells was robust predictor within 6-month time frame, with sensitivity 60% and specificity 97.8%. The diagnostic accuracy exceeded...
Journal Article Accepted manuscript Targeting autoimmunity with CD19-CAR T cell therapy: efficacy and seroconversion in diffuse systemic sclerosis rheumatoid arthritis Get access Fredrik N Albach, Albach Department of Rheumatology Clinical Immunology, Charité - Universitätsmedizin Berlin, Germany Search for other works by this author on: Oxford Academic PubMed Google Scholar Ioanna Minopoulou, Minopoulou Artur Wilhelm, Wilhelm GermanyDeutsches Rheuma-Forschungszentrum Robert Biesen, Biesen...
Objective.–To determine whether injections of botulinum toxin could be therapeutic value in the treatment tension‐type headache. Background.–Botulinum A is very effective at reducing muscle tenderness and pain many diseases. Increased tension may contribute to Methods.–We performed a double‐blind, placebo‐controlled study with 21 patients fulfilling International Headache Society criteria for Participants were randomly assigned (pericranial injection 10 × 20 mouse units A) or placebo...
Neurotoxicity of first-generation antipsychotics (FGAs) may be involved in lipid peroxidation, which is the pathogenesis extrapyramidal symptoms, including tardive dyskinesia (TD). Blood samples at day 0, 7, and 21 drawn from patients taking were analyzed for malondialdehyde (MDA) plasma, a marker by high-performance liquid chromatography. Of 115 enrolled, 92 completed study. Most MDA levels within normal ranges (<1.0 micromol/liter). Malondialdehyde receiving clozapine (p = 0.002),...
Objective To assess and analyse nutritional status in patients with systemic sclerosis (SSc) identify possible associations clinical symptoms its prognostic value. Methods Body mass index (BMI) parameters of bioelectrical impedance analysis (BIA) were assessed 124 SSc 295 healthy donors matched for sex, age BMI comparisons. In SSc, BIA values compared a cross-sectional study. prospective open analysis, survival changes the energy uptake induced by treatment evaluated. Results Patients had...
Diffuse myofiber necrosis in the context of inflammatory myopathy is hallmark immune-mediated necrotizing (IMNM). We have previously shown that skeletal muscle fibers IMNM patients may display nonrimmed vacuoles and sarcoplasmic irregularities. The dysfunctional chaperone activity has been linked to defective assembly proteins their degradation via lysosomes, autophagy proteasomal machinery. This study was undertaken highlight a chaperone-assisted selective (CASA) pathway, functionally...
Suboptimal patient adherence to pharmacological therapy of type 2 diabetes may be due in part pill burden. One way reduce burden patients who need multiple medications is use fixed-dose combinations. Our study aimed compare the effects combination versus loose-dose on medication and persistence, health care utilization, therapeutic safety, morbidities, treatment modification with over three years.