A5061578965- Rheumatoid Arthritis Research and Therapies
- Gout, Hyperuricemia, Uric Acid
- Spondyloarthritis Studies and Treatments
- Bone and Joint Diseases
- Musculoskeletal synovial abnormalities and treatments
- Systemic Sclerosis and Related Diseases
- Orthopedic Surgery and Rehabilitation
- Autoimmune and Inflammatory Disorders Research
- Systemic Lupus Erythematosus Research
- Case Reports on Hematomas
- Osteoarthritis Treatment and Mechanisms
- Venous Thromboembolism Diagnosis and Management
- Alkaline Phosphatase Research Studies
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Peripheral Nerve Disorders
- Tendon Structure and Treatment
- Inflammasome and immune disorders
- Liver Disease and Transplantation
- Dermatologic Treatments and Research
- Shoulder Injury and Treatment
- Nutrition and Health in Aging
- Lower Extremity Biomechanics and Pathologies
- Musculoskeletal pain and rehabilitation
- Veterinary medicine and infectious diseases
- Osteomyelitis and Bone Disorders Research
Marche Polytechnic University
2016-2025
University of Nottingham
2022-2025
Nottingham City Hospital
2024
Ospedale Cannizzaro
2023
Center for Rheumatology
2023
Innsbruck Medical University
2023
<h3>Importance</h3> Gout is associated with cardiovascular diseases. The temporal association between gout flares and events has not been investigated. <h3>Objective</h3> To investigate whether there a transient increase in risk of after recent flare. <h3>Design, Setting, Participants</h3> A retrospective observational study was conducted using electronic health records from the Clinical Practice Research Datalink England January 1, 1997, December 31, 2020. multivariable nested case-control...
Objective Calcium pyrophosphate deposition (CPPD) disease is prevalent and has diverse presentations, but there are no validated classification criteria for this symptomatic arthritis. The American College of Rheumatology (ACR) EULAR have developed the first‐ever CPPD disease. Methods Supported by ACR EULAR, a multinational group investigators followed established methodology to develop these criteria. generated lists candidate items refined their definitions, collected de‐identified patient...
Calcium pyrophosphate deposition (CPPD) disease is prevalent and has diverse presentations, but there are no validated classification criteria for this symptomatic arthritis. The American College of Rheumatology (ACR) EULAR have developed the first-ever CPPD disease.Supported by ACR EULAR, a multinational group investigators followed established methodology to develop these criteria. generated lists candidate items refined their definitions, collected de-identified patient profiles,...
To assess, in spondyloarthritis (SpA), the discriminative value of Outcome Measures Rheumatology (OMERACT) ultrasound lesions enthesitis and their associations with clinical features this population.
To test whether the double contour (DC) sign has a different dynamic behaviour in gout and calcium pyrophosphate deposition (CPPD) assessment of DC increases its accuracy diagnosis.This cross-sectional analysis included patients with meeting 2015 ACR/EULAR classification criteria crystal-proven diagnosis CPPD. Hyaline cartilages were explored by ultrasound (US) to detect (ie, abnormal hyperechoic band over superficial margin hyaline cartilages) during joint movement was evaluated ((ie,...
Objective Previous studies demonstrated that the risk of venous thromboembolism (VTE) is increased in patients with gout, but not whether there was a temporal association between gout flare and VTE. This study undertaken to evaluate potential associations Methods Data were obtained from electronic primary‐care records UK's Clinical Practice Research Datalink, which links data hospitalization mortality registers. Using self‐controlled case series analysis adjusted for season age, we evaluated...
Objective To evaluate the discriminatory ability of ultrasound in calcium pyrophosphate deposition disease (CPPD), using microscopic analysis menisci and knee hyaline cartilage (HC) as reference standard. Methods Consecutive patients scheduled for replacement surgery, due to osteoarthritis (OA), were enrolled. Each patient underwent examination HC knee, scoring each site presence/absence CPPD. Ultrasound signs inflammation (effusion, synovial proliferation power Doppler) assessed...
Objectives To investigate, in anti-cyclic citrullinated peptide antibody positive (CCP+) at-risk individuals without clinical synovitis, the prevalence and distribution of ultrasound (US) bone erosions (BE), their correlation with subclinical synovitis association development inflammatory arthritis (IA). Methods Baseline US scans 419 CCP+ were analysed. BE evaluated classical sites for rheumatoid damage: second fifth metacarpophalangeal (MCP2 MCP5) joints, metatarsophalangeal (MTP5) joints....
Deep learning applied to ultrasound (US) can provide a feedback the sonographer about correct identification of scanned tissues and allows for faster standardized measurements. The most frequently adopted parameter US diagnosis carpal tunnel syndrome is increasing cross-sectional area (CSA) median nerve. Our aim was develop deep algorithm, relying on convolutional neural networks (CNNs), localization segmentation nerve automatic measurement its CSA images acquired at proximal inlet...
To determine an US scanning protocol with the best accuracy for diagnosis of gout and CPPD in patients acute mono/oligo-arthritis unknown origin.Patients whom a joint aspiration at most clinically involved (target joint) was requested were consecutively enrolled. performed each patient before arthrocentesis. The different findings protocols calculated.A total 161 subjects included (32 patients, 30 99 disease-controls). had high specificity (0.92-0.96) (0.90-0.97), while sensitivity ranged...
The main objective of this study is to explore the prevalence and distribution entheseal US changes in a cohort SLE patients, taking as controls group including both PsA patients healthy subjects. secondary investigate correlation between findings clinical serological data patients.Clinical assessment quadriceps, patellar Achilles tendons, plantar fascia entheses were performed by independent rheumatologists on 65 with SLE, 50 identified according OMERACT definitions. In laboratory was...
Objective To investigate the temporal association between first diagnosis of gout and cardiovascular events in short term. Methods We performed a self‐controlled case series analysis cohort study using data from linked primary care, hospitalization, mortality records United Kingdom's Clinical Practice Research Database‐GOLD. included individuals with new either care or secondary January 1, 1997 December 31, 2020. The consultation at which was diagnosed exposure interest. main outcome...
Abstract Objectives To comparatively assess the sonographic spectrum of carpal tunnel syndrome (CTS) in patients with rheumatoid arthritis (RA) and idiopathic CTS. Methods Fifty-seven RA 25 CTS were consecutively enrolled. The diagnosis was made according to clinical history examination. following findings assessed at level: median nerve cross-sectional area (CSA) proximal inlet, finger flexor tendons tenosynovitis, radio-carpal synovitis intraneural power Doppler (PD) signal. Results...
To investigate the reliability of OMERACT US Task Force definition enthesitis in SpA.In this web exercise, based on evaluation 101 images and 39 clips main entheses lower limbs, elementary components included SpA (hypoechoic areas, entheseal thickening, power Doppler signal at enthesis, enthesophytes/calcifications, bone erosions) were assessed by 47 rheumatologists from 37 rheumatology centres 15 countries. Inter- intra-observer was calculated using Light's kappa, Cohen's Prevalence And...
The objectives of this study were (1) to explore US findings for muscle mass, quality and stiffness in SLE patients healthy subjects; (2) investigate the relationship between physical performance subjects.Quadriceps thickness was used assessment echogenicity (using a visual semi-quantitative scale grayscale analysis with histograms) quality, point shear-wave elastography (SWE) 30 (without previous/current myositis or neuromuscular disorders) 15 age-, sex- BMI-matched subjects. Hand grip...
Objective To describe demographic, clinical and laboratory features of systemic sclerosis sine scleroderma (ssSSc) in a large multicentre (SSc) cohort. Methods Data involving 1808 SSc patients from Italian Systemic PRogression INvestiGation registry were collected. The ssSSc was defined by the absence any cutaneous and/or puffy fingers. Clinical serological compared with limited (lcSSc) diffuse (dcSSc) subsets. Results Among SSc, only 61 (3.4%) classified as having (F/M=19/1). Time Raynaud’s...
Abstract Objectives Very little is known on the efficacy and safety of drugs for management chronic calcium pyrophosphate (CPP) crystal inflammatory arthritis. The objectives this work were to describe used in CPP arthritis expert European centres, examine treatment retention. Methods This was a retrospective cohort study. Charts from patients with diagnosis persistent and/or recurrent acute reviewed seven centres. Baseline characteristics collected, visits at months 3, 6, 12 24 included an...