A5101637263- Spondyloarthritis Studies and Treatments
- Rheumatoid Arthritis Research and Therapies
- Geological and Geochemical Analysis
- Autoimmune and Inflammatory Disorders Research
- earthquake and tectonic studies
- Bone and Joint Diseases
- Psoriasis: Treatment and Pathogenesis
- Dermatology and Skin Diseases
- Geochemistry and Geologic Mapping
- Histiocytic Disorders and Treatments
- GDF15 and Related Biomarkers
- T-cell and B-cell Immunology
- Osteomyelitis and Bone Disorders Research
- Hormonal Regulation and Hypertension
- Systemic Lupus Erythematosus Research
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Prostate Cancer Treatment and Research
- High-pressure geophysics and materials
- Parathyroid Disorders and Treatments
- Geophysical and Geoelectrical Methods
- Cancer, Hypoxia, and Metabolism
- Genital Health and Disease
- Apelin-related biomedical research
- Genetic and rare skin diseases.
- Infectious Diseases and Tuberculosis
Chinese PLA General Hospital
2014-2024
China University of Geosciences (Beijing)
2021-2022
Chinese People's Liberation Army
2015-2020
Tangshan People's Hospital
2009
Liaoning Provincial People's Hospital
2009
Abstract Background Secukinumab demonstrated sustained efficacy in patients with ankylosing spondylitis (AS) through 5 years pivotal Phase III studies. Here, we present and safety results (52-week) of secukinumab AS from the MEASURE study. Methods was a 52-week, III, China-centric Eligible were randomly assigned (2:1) to receive subcutaneous 150 mg or placebo weekly for first five doses then once every 4 weeks (q4w). All switched q4w starting at Week 16. Primary endpoint Assessments...
To investigate the reliability of OMERACT US Task Force definition enthesitis in SpA.In this web exercise, based on evaluation 101 images and 39 clips main entheses lower limbs, elementary components included SpA (hypoechoic areas, entheseal thickening, power Doppler signal at enthesis, enthesophytes/calcifications, bone erosions) were assessed by 47 rheumatologists from 37 rheumatology centres 15 countries. Inter- intra-observer was calculated using Light's kappa, Cohen's Prevalence And...
PGE2 elevates IL‐23 production in mouse dendritic cells while inhibits isolated human monocytes. Whether this differential effect of on is cell‐type‐ or species‐specific has not been investigated detail. The present study was designed to investigate the DCs and possible underlying mechanisms. Human monocytes derived (Mo‐DCs) were pretreated with without PGE2. Then incubated zymosan. Our results demonstrated that promoted zymosan‐induced a concentration dependent manner. In addition, it found...
The post-collisional Gangdese metallogenic belt with over 45 Mt Cu has attracted worldwide attention. We report the whole-rock geochemistry, zircon SIMS U–Pb geochronology, and in situ Hf–O isotopic compositions of Jiama deposit belt. intermediate to felsic intrusive rocks are characterized by high SiO2 (64.8 78.8 wt. %) Al2O3 (12.1 16.3 contents, Sr/Y ratios (43–74), showing geochemical characteristics adakites. Zircons from four intrusives yield ages 16.19 ± 0.20 Ma, 15.67 0.32 15.44 0.16...
Objective The aim of this study was to set up a large, longitudinal and prospective database investigate epidemiology, pathogenesis,the diagnosis, prognosis ankylosing spondylitis (AS) in Chinese population. Methods Four hundreds, forty-nine consecutive outpatients with confirmed AS were recruited followed annually. Characteristics registration demography (age, gender, time back pain onset presence AS-related clinical manifestations features, family history) the current condition...
<h3>Background</h3> Secukinumab (SEC), a fully human monoclonal antibody to IL-17A, has demonstrated significant and sustained efficacy in patients (pts) with ankylosing spondylitis (AS) across several phase 3 studies.<sup>1-3</sup> MEASURE 5 (NCT02896127) is placebo (PBO)-controlled China centric 1-year study pts active AS. <h3>Objectives</h3> To present the primary safety results of study. <h3>Methods</h3> Pts were randomised (2:1) receive subcutaneous (s.c.) SEC 150 mg or PBO at baseline...
Objective To investigate the characteristics and differences of enthesopathy ultrasonic imaging in lower limbs patients with psoriasis(Ps) psoriatic arthritis(PsA), to explore risk factors Ps developing PsA future. Methods Sex- age-matched Ps, HC who visited dermatological rheumatic outpatient PLA General Hospital were enrolled. Ultrasound entheses (quadriceps insertions, patellar tendon origins Achilles plantar fascia insertion) performed using a Logiqe R6 machine, both linear probe...
Objective To study the characteristics of work disability and its influencing factors in patients with ankylosing spondylitis (AS). Methods The demographic data, conditons disease related 277 AS were recorded, randomly selected from Department Rheumatology, Chinese PLA General Hospital November 2014 to January 2016. Work productivity activity impair-ment questionnaire (WPAI) was used survey loss, then explore in-fluencing relationships between patient-reported outcomes WPAI scores....