A5100654295- Renal cell carcinoma treatment
- Spondyloarthritis Studies and Treatments
- Bladder and Urothelial Cancer Treatments
- Stroke Rehabilitation and Recovery
- Renal and related cancers
- IgG4-Related and Inflammatory Diseases
- Spine and Intervertebral Disc Pathology
- Prostate Cancer Diagnosis and Treatment
- Rheumatoid Arthritis Research and Therapies
- Head and Neck Cancer Studies
- Minimally Invasive Surgical Techniques
- Pancreatitis Pathology and Treatment
- Psoriasis: Treatment and Pathogenesis
- Transcranial Magnetic Stimulation Studies
- Gastrointestinal disorders and treatments
- Bone and Joint Diseases
- Urinary and Genital Oncology Studies
- Viral gastroenteritis research and epidemiology
- Botulinum Toxin and Related Neurological Disorders
- Neuroendocrine Tumor Research Advances
- Autoimmune and Inflammatory Disorders Research
- Tribology and Wear Analysis
- Balance, Gait, and Falls Prevention
- Renal and Vascular Pathologies
- Head and Neck Surgical Oncology
Shanghai University of Traditional Chinese Medicine
2019-2025
Shanghai University of Sport
2024-2025
Lanzhou University Second Hospital
2022-2025
Lanzhou University
2022-2025
Institute of Botany
2021-2025
Chinese Academy of Sciences
2021-2025
University of Chinese Academy of Sciences
2021-2025
Sun Yat-sen University
2004-2025
Sun Yat-sen University Cancer Center
2023-2025
Chinese PLA General Hospital
2016-2025
Hepatitis E virus (HEV), a small, non-enveloped RNA in the family Hepeviridae , is associated with endemic and epidemic acute viral hepatitis developing countries. Our 3.5-Å structure of HEV-like particle (VLP) shows that each capsid protein contains 3 linear domains form distinct structural elements: S, continuous capsid; P1, 3-fold protrusions; P2, 2-fold spikes. The S domain adopts jelly-roll fold commonly observed small viruses. P1 P2 both adopt β-barrel folds. Each possesses potential...
Cryodamage is a major problem in semen cryopreservation, causing changes the levels of proteins that influence function and motility spermatozoa. In this study, protein samples prepared from fresh frozen-thawed boar spermatozoa were compared using isobaric tags for relative absolute quantification (iTRAQ) labeling technique coupled to 2D LC-MS/MS analysis. A total 41 differentially expressed identified quantified, including 35 present at higher six lower by least mean 1.79-fold (P<0.05). On...
Abstract Aristolochia , a genus in the magnoliid order Piperales, has been famous for centuries its highly specialized flowers and wide medicinal applications. Here, we present new, high-quality genome sequence of fimbriata species that, similar to Amborella trichopoda lacks further whole-genome duplications since origin extant angiosperms. As such, A. is an excellent reference inferences angiosperm evolution, enabling detection two novel Piperales dating previously reported other...
JCO
Background: With the rapid advancement of artificial intelligence in health care, large language models (LLMs) demonstrate increasing potential medical applications. However, their performance specialized oncology remains limited. This study evaluates multiple leading LLMs addressing clinical inquiries related to bladder cancer (BLCA) and demonstrates how strategic optimization can overcome these limitations. Methods: We developed a comprehensive set 100 questions based on established...
The aim of the study was to establish life cycle severe acute respiratory syndrome-associated coronavirus (SARS CoV) in host cells and determine pathogenesis SARS. Vero E6 (African green monkey kidney cells) were inoculated with SARS for 3, 7, 24, 48, 72 hr, respectively, observed under electron microscope. It found that entered through membrane fusion instead endocytosis, then nucleocapsids assembled RER matured by budding into smooth vesicles, which derived from Golgi apparatus. vesicles...
Abstract: This article focuses on a range of non-pharmacological strategies for managing sarcopenia in chronic diseases, including exercise, dietary supplements, traditional Chinese intestinal microecology, and rehabilitation therapies individuals with limited limb movement. By analyzing multiple studies, the aims to summarize available evidence manage diseases. The results strongly emphasize role resistance training addressing diseases secondary sarcopenia. Maintaining appropriate frequency...
Homotypic interactions of viral capsid proteins are common, driving self-formation. By taking advantage such the norovirus shell (S) domain that naturally builds interior shells capsids, we have developed a technology to produce 60-valent, icosahedral S60 nanoparticles through E. coli system. This has been achieved by several modifications S domain, including an R69A mutation destruct exposed proteinase cleavage site and triple cysteine mutations (V57C/Q58C/S136C) establish inter-S disulfide...
Ankylosing spondylitis (AS) is a chronic disease that decreases mobility, function, and quality of life. This study introduced the "Smart-phone SpondyloArthritis Management System" (SpAMS), an interactive mobile health (mHealth) tool designed for AS/spondyloarthritis (SpA) management used SpAMS data to evaluate clinical characteristics Chinese patients with AS.SpAMS integrates patient's physician's portals in smart phone application. The Spondylitis Prospective Imaging Cohort was launched...