A5068864315- Osteoarthritis Treatment and Mechanisms
- MicroRNA in disease regulation
- Pregnancy and preeclampsia studies
- Wound Healing and Treatments
- Circular RNAs in diseases
- Mesenchymal stem cell research
- Reproductive System and Pregnancy
- Inflammatory mediators and NSAID effects
- Tissue Engineering and Regenerative Medicine
- Birth, Development, and Health
- Spine and Intervertebral Disc Pathology
- Vascular Malformations and Hemangiomas
- Legume Nitrogen Fixing Symbiosis
- Dermatologic Treatments and Research
- Natural product bioactivities and synthesis
- Extracellular vesicles in disease
- Periodontal Regeneration and Treatments
- Cancer-related molecular mechanisms research
- Electrospun Nanofibers in Biomedical Applications
- Genomics and Phylogenetic Studies
- Plant and Fungal Species Descriptions
- Plant-based Medicinal Research
- Viral Infections and Immunology Research
- Plant-Microbe Interactions and Immunity
- Cardiac Arrest and Resuscitation
University of Chinese Academy of Sciences
2014-2025
Chinese Academy of Sciences
2012-2025
Institute of Botany
2018-2025
Shanghai Ninth People's Hospital
2016-2025
Shanghai Jiao Tong University
2016-2025
Jilin University
2021-2025
First Hospital of China Medical University
2025
China Medical University
2025
Technical Institute of Physics and Chemistry
2022-2025
First Hospital of Jilin University
2021-2025
Preeclampsia is a major cause of maternal and fetal mortality morbidity worldwide. The differential expression several microRNAs (miRNAs) has been found in preeclamptic placentas. However, great conflict exists regarding this aspect, detailed examinations have largely lacking miRNA profiles different parts the placenta plasma women with disorder. In study, total 9 downregulated miRNAs (miR-195, miR-223, miR-218, miR-17, miR-18a, miR-19b1, miR-92a1, miR-379, miR-411) 7 upregulated (miR-210,...
Abstract Extracellular vesicles have shown promising tissue recovery-promoting effects, making them increasingly sought-after for their therapeutic potential in wound treatment. However, traditional extracellular vesicle applications suffer from limitations such as rapid degradation and short maintenance during administration. To address these challenges, a growing body of research highlights the role hydrogels effective carriers sustained release, thereby facilitating healing. The...
Abstract Autophagy is essential in physiological and pathological processes, however, the role of autophagy cutaneous wound healing underlying molecular mechanism remain elusive. We hypothesized that plays an important regulating healing. Here, we show enhanced negatively impacts on normal process related to chronic wounds as demonstrated by increased LC3 diabetic mice skin or patients’ wounds. In addition, inhibition 3-MA restores delayed C57BL/6 db/db mice, demonstrating involved...
Preeclampsia is a pregnancy-specific syndrome manifested by the onset of hypertension and proteinuria after 20th week gestation. Abnormal placenta development has been generally accepted as initial cause disorder. Recently, microRNA-210 (miR-210) found to be upregulated in preeclamptic placentas compared with normal placentas, indicating possible association this small molecule placental pathology preeclampsia. However, function miR-210 remains elusive. The aim study was characterize...
Abstract Preeclampsia, a relatively common pregnancy disorder, is major contributor to maternal mortality and morbidity worldwide. An elevation in microRNA-210 (miR-210) expression the placenta has been reported be associated with preeclampsia. Our bioinformatic analysis showed that thrombospondin type I domain containing 7A (THSD7A) predicted target for miR-210. The aim of this study was determine whether miR-210 involved preeclampsia through its targeting THSD7A human placental...
Abstract Aristolochia , a genus in the magnoliid order Piperales, has been famous for centuries its highly specialized flowers and wide medicinal applications. Here, we present new, high-quality genome sequence of fimbriata species that, similar to Amborella trichopoda lacks further whole-genome duplications since origin extant angiosperms. As such, A. is an excellent reference inferences angiosperm evolution, enabling detection two novel Piperales dating previously reported other...
Abstract Background Large numbers of adipose-derived stem cells (ADSCs) are easily obtained and have been demonstrated to protect against ultraviolet B (UVB)-induced skin photoaging. Extracellular vesicles (EVs) exhibit some the same effects as from which they originate many advantages over cells. In particular, their application circumvents safety concerns associated with cell therapy. Thus, a cell-free agent, extracellular (ADSC-EVs) anti-photoaging potential. However, protective ADSC-EVs...
Abstract Cultivated chrysanthemum (Chrysanthemum × morifolium Ramat.) is a beloved ornamental crop due to the diverse capitula types among varieties, but molecular mechanism of capitulum development remains unclear. Here, we report 2.60 Gb chromosome-scale reference genome C. lavandulifolium, wild Chrysanthemum species found in China, Korea and Japan. The evolutionary analysis revealed that only recent tandem duplications occurred lavandulifolium after shared whole triplication (WGT)...
Abstract Background Plants sustain intimate relationships with diverse microbes. It is well-recognized that these plant-associated microbiota shape individual performance and fitness of host plants, but much remains to be explored regarding how they exert their function maintain homeostasis. Results Here, using pink lady ( Heterotis rotundifolia ) as a study plant, we investigated the phenomenon microbiota-mediated nitrogen fixation elucidated this process steadily maintained in root...
Assembly of a high-quality genome is important for downstream comparative and functional genomic studies. However, most tools assembly assessment only give qualitative reports, which do not pinpoint errors at specific regions. Here, we develop new reference-free tool, Clipping information Revealing Quality (CRAQ), maps raw reads back to assembled sequences identify regional structural based on effective clipped alignment information. Error counts are transformed into corresponding evaluation...
The purpose of this study is to develop an innovative solution for chronic wounds in high-mobility areas, such as joints, where conventional treatments are hindered by passive healing mechanisms and the need immobilization. By designing a micro-electro-Nanofiber dressing composed piezoelectric polyvinylidene fluoride (PVDF) integrated with antimicrobial silver nanoparticles (AgNPs), research aims address dual challenges promoting effective wound maintaining joint mobility. Herein, we...
Background Preeclampsia (PE) is a pregnancy-specific syndrome manifested by on-set of hypertension and proteinuria after 20 weeks gestation. Abnormal placenta development has been generally accepted as initial cause the disorder. Recently, miR-195 was found to be down-regulated in preeclamptic placentas compared with normal pregnant ones, indicating possible association this small molecule placental pathology preeclampsia. By far function remains unknown. Methodology/Principal Findings...
Root (rhizome) rot of Polygonatum plants has received substantial attention because it threatens yield and sustainable utilization in the polygonati rhizome industry. However, potential pathogens that cause as well direct indirect (via root-associated microbes) strategies by which defends against remain largely unknown. Herein, we used integrated multiomics plant-targeted metabolomics transcriptomics, microbiome, culture-based methods to systematically investigate interactions between...
By mimicking natural lubricin, a tailored polyzwitterionic armor, which exhibited cartilage targeting, anti-degradation and anti-oxidation chondrogenesis properties, was designed for drug-free osteoarthritis therapy.
A longstanding concern in plant essential oil extraction is how to optimize efficiency with limited materials. Supercritical CO2 has been proven effective enhancing the yield and of extracting oils. However, impact temperature, pressure, co-solvent content on Hetian rose remains unclear. There a lack research influence pretreatment methods. This study focuses investigating supercritical oils from Xinjiang Hetian. The analyzes effects pressure temperature rate validates by calculating...
The mechanisms of hypertrophic scar formation are not fully understood. We previously screened the differentially expressed genes human tissue and identified P311 gene as upregulated. As activities in fibroblast function unknown, we examined distribution it effects forced expression or silencing P311. was detected fibroblast-like cells from burn injury patients but peripheral blood mononuclear cells, bone marrow mesenchymal stem epidermal normal skin dermal cells. Transfection fibroblasts...