A5100347836- RNA modifications and cancer
- Cancer-related gene regulation
- Cancer-related molecular mechanisms research
- Cancer Genomics and Diagnostics
- Microtubule and mitosis dynamics
- Epigenetics and DNA Methylation
- Endoplasmic Reticulum Stress and Disease
- Chinese history and philosophy
- RNA Research and Splicing
- Lung Cancer Treatments and Mutations
- Ubiquitin and proteasome pathways
- Cancer Mechanisms and Therapy
- MicroRNA in disease regulation
- Cancer, Lipids, and Metabolism
- Autophagy in Disease and Therapy
- Ferroptosis and cancer prognosis
- Cancer-related Molecular Pathways
- Cancer Cells and Metastasis
- China's Ethnic Minorities and Relations
- Lung Cancer Research Studies
- Circular RNAs in diseases
- RNA regulation and disease
- Cancer, Hypoxia, and Metabolism
- Neuroscience and Neuropharmacology Research
- Hair Growth and Disorders
Peking University Cancer Hospital
2019-2025
Tianjin Medical University General Hospital
2010-2025
Peking University
2010-2025
Guangzhou Medical University
2016-2025
West China Hospital of Sichuan University
2010-2025
Beijing University of Posts and Telecommunications
2023-2025
Sichuan University
2010-2025
Sichuan Cancer Hospital
2025
Tianjin Medical University
2010-2024
Hebei University
2024
<h3>Objective</h3> Hepatocellular carcinoma (HCC) is a heterogeneous tumour displaying complex variety of genetic and epigenetic changes. In human cancers, aberrant post-transcriptional modifications, such as alternative splicing RNA editing, may lead to specific transcriptome diversity. <h3>Design</h3> By utilising large scale sequencing three paired HCC clinical specimens their adjacent non-tumour (NT) tissue counterparts at depth, we discovered an average 20 007 inferred A I (adenosine...
Abstract Background Laryngeal cancer has the highest mortality rate among head and neck tumours. RNA N6-methyladenosine (m6A) is most plentiful variable in mammalian mRNA. Yet, m6A regulatory mechanism underlying carcinogenesis or progression of LSCC remains poorly understood. Methods The methylation quantification kit was used to detect tissue levels. microarray analysis, mRNA transcriptomic sequencing (mRNA-seq), proteomics were determine RBM15, TMBIM6, IGF2BP3. Immunohistochemical (IHC),...
Despite recent progress in non-small-cell lung cancer (NSCLC) treatment, treatment outcomes remain poor, mainly because of resistance or toxicity. Erastin is a ferroptosis inducer that has shown promising cytotoxic effects various types cancers, including NSCLC. Celastrol triterpene extracted from the Tripterygium wilfordii exhibits potential anticancer activity. However, side celastrol are severe and limit its clinical application. Combination therapy strategy to overcome compensatory...
This open-label phase II trial (NCT04542837) aimed to evaluate the efficacy and safety of KN046 combined with lenvatinib in patients advanced hepatocellular carcinoma (HCC), explore potential response biomarkers. Participants received 5 mg/kg every 3 weeks 12 or 8 mg once daily. The primary endpoints were safety, tolerability, dose-limiting toxicity (DLT), objective rate (ORR) according RECIST v1.1. A total fifty-five participants enrolled. results meet pre-specified endpoints. No DLT was...
Objective After a recent small subcortical infarct (RSSI), some patients develop perilesional or remote hyperintensities (‘caps/tracks’) to the index on T2/FLAIR MRI. However, their clinical relevance remains unclear. We investigated clinicoradiological correlates of ‘caps/tracks’, and impact long‐term outcomes following RSSI. Methods identified participants with lacunar stroke MRI‐confirmed RSSI from 3 prospective studies. At baseline, we collected risk factors, characteristics, vessel...
Distinguishing between symptoms of posterior circulation infarction (PCI) and anterior (ACI) can be challenging. This study evaluated the frequency symptoms/signs in 2 vascular territories to determine diagnostic value particular for PCI.Neurological deficits were reviewed compared from 1174 consecutive patients with a diagnosis PCI or ACI confirmed by magnetic resonance imaging Chengdu Stroke Registry. The specific was determined measuring their sensitivity, specificity, positive predictive...
Necroptosis is an emerging programmed necrosis other than traditional and apoptosis. Until recently, there have not been studies that investigated a relationship between necroptosis pathogenesis of cell death after spinal cord injury (SCI).To investigate whether takes part in the early pathophysiological processes traumatic SCI mice.Female ICR mice were randomized equally into three groups: sham, vehicle-treated + group, Nec-1-treated group. To induce SCI, subjected to laminectomy at T9...
Breast cancer represents the second leading cause of cancer-related deaths among women worldwide and preventive therapy could reverse or delay devastating impact this disease. Ellagic acid (EA), a dietary flavonoid polyphenol which is present in abundance pomegranate, muscadine grapes, walnuts strawberries, has been shown to inhibit cells proliferation induce apoptosis. Here, we investigated growth inhibitory effects EA on MCF-7 breast cells. In study, first found that inhibits mainly...
Preeclampsia is a pregnancy-specific syndrome manifested by the onset of hypertension and proteinuria after 20th week gestation. Abnormal placenta development has been generally accepted as initial cause disorder. Recently, microRNA-210 (miR-210) found to be upregulated in preeclamptic placentas compared with normal placentas, indicating possible association this small molecule placental pathology preeclampsia. However, function miR-210 remains elusive. The aim study was characterize...
Community-acquired pneumonia (CAP) contributes substantially to morbidity and mortality in children under the age of 5 years. In examining bronchoalveolar lavages (BALs) with CAP, we found that interleukin-17 (IL-17) production was significantly increased severe CAP. Immune profiling showed mucosal-associated invariant T (MAIT) cells from BALs, but not blood, CAP patients actively produced IL-17 (MAIT17). Single-cell RNA-sequencing revealed MAIT17 resided a BAL-resident PLZFhiCD103+ MAIT...
Abstract Growing evidences suggest that cancer stem cells exhibit many molecular characteristics and phenotypes similar to their ancestral progenitor cells. In the present study, human embryonic are induced differentiate into hepatocytes along hepatic lineages mimic liver development in vitro. A specific gene, RALY RNA binding protein like ( RALYL ), is identified. expression associated with poor prognosis, differentiation, metastasis clinical HCC patients. Functional studies reveal could...
CLDN6 is not only a marker of hepatocellular carcinoma but also therapeutic target by promoting sorafenib resistance and lineage plasticity.
Genomic studies have demonstrated a high frequency of genetic alterations in components the SWI/SNF complex including core subunit SMARCA4. However, mechanisms tumorigenesis driven by SMARCA4 mutations, particularly colorectal cancer (CRC), remain largely unknown. In this study, we identified specific, hotspot mutation (c. 3721C>T) which results conversion from arginine to tryptophan at residue 1157 (R1157W) human CRC tissues associated with higher-grade tumors and controls progression....
The high frequency of epidermal growth factor receptor (EGFR) mutations in tyrosine kinase inhibitor-responsive non-small-cell lung cancer (NSCLC) cases is now well established, highlighting the predictive value activating EGFR guiding clinical use EGFR-targeted therapies. However, specimen source and methods for mutation analysis are limited by tissue availability technical feasibility application. Therefore, current study designed to establish a blood-based approach assessment NSCLC...