Caroline M.J. Loos
A5074040243- Acute Ischemic Stroke Management
- Cerebrovascular and Carotid Artery Diseases
- Atrial Fibrillation Management and Outcomes
- Intracerebral and Subarachnoid Hemorrhage Research
- Cerebrovascular and genetic disorders
- Venous Thromboembolism Diagnosis and Management
- Cardiovascular Health and Disease Prevention
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Long-Term Effects of COVID-19
- Lipoproteins and Cardiovascular Health
- Neurosurgical Procedures and Complications
- Advanced MRI Techniques and Applications
- Cardiac Imaging and Diagnostics
- Stroke Rehabilitation and Recovery
- Traumatic Brain Injury and Neurovascular Disturbances
- Vascular Malformations Diagnosis and Treatment
- Cell Adhesion Molecules Research
- Retinal and Optic Conditions
- Neurological Complications and Syndromes
- Antiplatelet Therapy and Cardiovascular Diseases
- Cerebrospinal fluid and hydrocephalus
- Ruminant Nutrition and Digestive Physiology
- COVID-19 and healthcare impacts
- Electron Spin Resonance Studies
- Neurological Disease Mechanisms and Treatments
Antwerp University Hospital
2018-2025
University of Antwerp
2021-2025
University of Kentucky
2024
Maastricht University Medical Centre
2012-2018
Universitair Ziekenhuis Leuven
2018
University of Edinburgh
2012
Ghent University Hospital
2010
In patients with atrial fibrillation who suffered an ischemic stroke while on treatment nonvitamin K antagonist oral anticoagulants, rates and determinants of recurrent events major bleedings remain uncertain.This prospective multicenter observational study aimed to estimate the bleeding their in follow-up consecutive acute cerebrovascular event anticoagulant treatment. Afterwards, we compared estimated risks between whom therapy was changed those continued original treatment.After a mean...
Whether infarct size modifies the treatment effect of early vs late direct oral anticoagulant (DOAC) initiation in people with ischemic stroke and atrial fibrillation is unknown.
Objective After a recent small subcortical infarct (RSSI), some patients develop perilesional or remote hyperintensities (‘caps/tracks’) to the index on T2/FLAIR MRI. However, their clinical relevance remains unclear. We investigated clinicoradiological correlates of ‘caps/tracks’, and impact long‐term outcomes following RSSI. Methods identified participants with lacunar stroke MRI‐confirmed RSSI from 3 prospective studies. At baseline, we collected risk factors, characteristics, vessel...
Objectives Perivascular spaces are associated with MRI markers of cerebral small vessel disease, including white matter hyperintensities. Although perivascular considered to be an early marker it is unknown whether they further progression markers, especially We determined the association between and hyperintensities after 2-year follow-up in lacunar stroke patients. Methods In 118 patients we obtained brain 24-hour ambulatory blood pressure measurements at baseline, a 2 years later....
Background and Purpose— Insights into evolution of cerebral small vessel disease on neuroimaging might advance knowledge the natural course. Data sporadic symptomatic lacunar infarcts are limited. We investigated long-term changes surrounding white matter structural magnetic resonance imaging. Methods— From 2 nonoverlapping, single-center, prospective observational stroke studies, we selected patients presenting with symptoms a recent subcortical (lacunar) infarct baseline imaging follow-up...
Studies in patients with lacunar stroke often assess the number of lacunes. However, data on how many symptomatic infarcts cavitate into a lacune are limited. We assessed evolution over 2-year follow-up.In 82 first-ever infarct deep brain regions (excluding centrum semiovale), we performed MR at presentation and 2 years later. classified cavitation baseline follow-up as absent, incomplete, or complete. recorded time to imaging, size, vascular risk factors.On MR, 38 (46%) index showed...
Introduction: The efficacy and safety of statins for secondary prevention in patients who have experienced a cardioembolic stroke are not well-defined. However, previous observational data reported hyperlipidemia as risk factor both ischemic bleeding complications with AF stroke. Based on these premises, we conducted sub-analysis the RAF RAF-NOAC studies to evaluate acute AF. Materials methods: We combined patient from studies, prospective across Stroke Units Europe, United States, Asia...
Importance The net clinical effect of early vs later direct oral anticoagulant (DOAC) initiation after atrial fibrillation–associated ischemic stroke is unclear. Objective To investigate whether DOAC treatment associated with a benefit (NCB). Design, Setting, and Participants This was post hoc analysis the Early Versus Late Initiation Direct Oral Anticoagulants in Post–Ischaemic Stroke Patients With Atrial Fibrillation (ELAN) open-label randomized trial conducted across 103 sites 15...
Background and aims Individual MRI markers of cerebral small vessel disease are associated with gait impairment. The impact total disease-related brain damage, expressed by a burden score, on mobility after stroke, has not been considered, although this score gives better representation the overall effect brain. We determined if is impairment three years minor stroke. Methods In total, 200 patients lacunar or non-lacunar stroke (NIHSS ≤ 7) underwent at presentation. Presence lacunes, white...
Introduction: Ischaemic stroke patients with atrial fibrillation (AF) are at high risk of recurrence despite oral anticoagulation therapy. Patients cardiovascular comorbidities may take both antiplatelet and therapy (OAC/AP). Our study aims to evaluate the safety efficacy OAC/AP as secondary prevention in people AF ischaemic stroke. methods: We performed a post-hoc analysis pooled individual data from multicenter prospective cohort studies compared outcomes on DOAC/VKA alone (OAC cohort)....
Introduction: Patients with ischemic stroke (IS) and atrial fibrillation (AF) face a higher risk of recurrent vascular events. This study evaluates the impact atherosclerotic disease burden across different territories on events in patients recent AF within 90 days. Methods: We included IS from International RAF network prospective 90-day follow-up. Atherosclerotic was identified by at least one following: Symptomatic heart disease, symptomatic peripheral artery internal carotid stenosis...
Until a few years ago, metastatic melanoma had poor prognosis with limited treatment options. These therapeutics options and thereby median survival have increased obviously over 5 the arrival of immunotherapeutic drugs like ipilimumab, nivolumab, pembrolizumab. Nowadays, ipilimumab is often used in patients melanoma. In this paper, we report case 68-year-old man who developed, eventually died of, herpes encephalitis after introducing as for To our knowledge, first which complication...
Atrial fibrillation (AF) and congestive heart failure often coexist due to their shared risk factors leading potential worse outcome, particularly cerebrovascular events. The aims of this study were calculate the rates ischemic severe bleeding events in stroke patients having both AF reduced ejection fraction (rEF) (⩽40%), compared with but without rEF. We performed a retrospective analysis that drew data from prospective studies. primary outcome was composite either (stroke or systemic...
Abstract Background The efficacy and safety of statins for secondary prevention in patients who have experienced a cardioembolic stroke are not well-defined. However, previous observational data reported hyperlipidemia as risk factor both ischemic bleeding complications with AF stroke. Based on these premises, we conducted sub-analysis the RAF RAF-NOAC studies to evaluate acute AF. Methods We combined patient from studies, prospective across Stroke Units Europe, United States, Asia January...
Insulin dysregulation (ID) is associated with an increased risk of laminitis which often necessitates the need for clinical intervention. To test contention that prophylactic supplementation nutraceuticals could mitigate ID in susceptible horses, 16 mature horses a history were supplemented either placebo (
Flat detector computed tomography (FD-CT) technology is becoming more widely available in the angiography suites of comprehensive stroke centers. In patients with acute ischemic (AIS), who are referred for endovascular therapy (EVT), FD-CT generates cerebral pooled blood volume (PBV) maps, which might help predicting final infarct area. We retrospectively analyzed pre- and post-recanalization quantitative PBV measurements both infarcted hypoperfused brain areas AIS EVT.We included large...