A5000719727- Acute Ischemic Stroke Management
- Cerebrovascular and Carotid Artery Diseases
- Traumatic Brain Injury and Neurovascular Disturbances
- Venous Thromboembolism Diagnosis and Management
- Intracerebral and Subarachnoid Hemorrhage Research
- Stroke Rehabilitation and Recovery
- Atrial Fibrillation Management and Outcomes
- Cardiovascular Health and Disease Prevention
- Cerebrovascular and genetic disorders
- Advanced Neuroimaging Techniques and Applications
- Neurological Disease Mechanisms and Treatments
- Heart Rate Variability and Autonomic Control
- Cardiac Arrhythmias and Treatments
- Cardiovascular Syncope and Autonomic Disorders
- Intensive Care Unit Cognitive Disorders
- Dementia and Cognitive Impairment Research
- Retinal Imaging and Analysis
- Cardiac Imaging and Diagnostics
- Neurological Disorders and Treatments
- Retinal Diseases and Treatments
- Blood Pressure and Hypertension Studies
- Inflammatory Biomarkers in Disease Prognosis
- Intracranial Aneurysms: Treatment and Complications
- Liver Disease Diagnosis and Treatment
- Anesthesia and Sedative Agents
Medical University of Graz
2016-2025
Medical University of Vienna
2021-2024
University of Basel
2017-2024
University Hospital of Bern
2024
University of Bern
2024
University College London
2023-2024
MRC Prion Unit
2024
University Hospital of Basel
2017-2024
The effect of early as compared with later initiation direct oral anticoagulants (DOACs) in persons atrial fibrillation who have had an acute ischemic stroke is unclear.We performed investigator-initiated, open-label trial at 103 sites 15 countries. Participants were randomly assigned a 1:1 ratio to anticoagulation (within 48 hours after minor or moderate on day 6 7 major stroke) (day 3 4 stroke, 12, 13, 14 stroke). Assessors unaware the trial-group assignments. primary outcome was composite...
To explore whether serum neurofilament light chain protein (NfL) levels are increased in patients with MRI-confirmed recent small subcortical infarcts (RSSI) compared to healthy controls and determine the subsequent course determinants of NfL a longitudinal manner.In prospectively collected group symptomatic an RSSI (n = 79, mean age 61 ± 11 years, 67% male), we analyzed brain MRI using Single Molecule Array (Simoa) assay at baseline 3 15 months after stroke. Community-dwelling age-...
Whether infarct size modifies the treatment effect of early vs late direct oral anticoagulant (DOAC) initiation in people with ischemic stroke and atrial fibrillation is unknown.
Background and purpose Cerebral hyperperfusion has been related to the risk of intracranial hemorrhage (ICH) in stroke patients after vessel recanalization therapy. We hypothesized that successful mechanical thrombectomy for acute anterior circulation stroke, hemodynamics detectable by transcranial Duplex (TCD) sonography would vary, increased blood flow velocities be associated with ICH. Methods retrospectively identified all ischemic endovascular occlusion (Thrombolysis Infarction 2b–3)...
Assessing the risk of recurrent intracerebral hemorrhage (ICH) is high clinical importance. MRI-based cerebral small vessel disease (SVD) markers may help establish ICH etiologic subtypes (including cryptogenic ICH) relevant for recurrence risk.We investigated in a large cohort consecutive survivors with available MRI at baseline. Patients macrovascular, structural, or other identified secondary causes (other than SVD) were excluded. Based on findings, etiology was defined as probable...
Whether hemorrhagic transformation (HT) modifies the treatment effect of early compared with late initiation direct oral anticoagulation in people ischemic stroke and atrial fibrillation is unknown.
Cerebral amyloid angiopathy (CAA)-associated lobar intracerebral hemorrhage (ICH) has a high risk of recurrence, but the underlying mechanisms remain uncertain. We, therefore, aimed to characterize patterns recurrent ICH.
Information on microstructural white matter integrity has been shown to explain post-stroke recovery beyond clinical measures and focal brain damage. Especially, knowledge about early changes might improve prediction of outcome. We investigated 42 acute reperfused ischemic stroke patients (mean age 66.5 years, 40% female, median admission NIHSS 9.5) with a symptomatic MRI-confirmed unilateral middle cerebral artery territory infarction 24-72 h after 3 months. All underwent neurological...
Abstract Background and purpose Atrial fibrillation (AF) often remains undiagnosed in cryptogenic stroke (CS), mostly because of limited availability cardiac long‐term rhythm monitoring. There is an unmet need for a pre‐selection CS patients benefitting from such work‐up. A clinical risk score was therefore developed the prediction AF after its performance evaluated over 1 year follow‐up. Methods Our proposed ranges 0 to 16 points comprises variables known be associated with occult including...
Background and purpose Information on the prevalence course of post‐stroke cognitive impairment in young stroke patients is limited. The aim was to assess a consecutive sample acute ischaemic (18–55 years) for presence development neuropsychological deficits. Methods Patients prospectively underwent comprehensive clinical assessment, examining general function, processing speed, attention, flexibility/executive function word fluency within first 3 weeks after hospital admission (median...
We aimed to explore the morphological evolution of recent small subcortical infarcts (RSSIs) over 15 months. Moreover, we hypothesized that quantitative lesion apparent diffusion coefficient (ADC) values and serum neurofilament light (NfL) levels predict subsequent lacunar cavitation. prospectively studied 78 RSSI patients, who underwent pre-defined follow-up investigations three months poststroke using 3 T MRI including high-resolution T1 sequences. To identify potential predictors...
Background and Purpose- Occult atrial fibrillation (AF) causes a relevant proportion of initially cryptogenic stroke (CS), but prolonged rhythm monitoring is difficult to apply all such patients. We hypothesized that blood biomarkers indicating heart failure (NT-proBNP [N-terminal pro-brain natriuretic peptide]) hypercoagulability (D-dimer, AT-III [antithrombin-III]) were associated with AF-related could serve predict the likelihood AF detection in CS patients early on. Methods- Over 1-year...
Background: Liver fibrosis has been identified as an outcome predictor in cardiovascular disease and associated with hematoma expansion mortality patients primary intracerebral hemorrhage. We aimed to explore whether clinically inapparent liver is related neurological outcome, mortality, intracranial hemorrhage risk ischemic stroke after mechanical thrombectomy. Methods: included consecutive anterior circulation large vessel occlusion treated at our center thrombectomy between January 2011...
Abstract Data on the impact of kidney dysfunction outcome in patients with stroke due to large vessel occlusion are scarce. The few available studies limited by only considering single parameters measured at one time point. We thus investigated influence both chronic disease (CKD) and acute injury (AKI) after mechanical thrombectomy. included consecutive anterior circulation receiving thrombectomy our center over an 8-year period. extracted clinical data from a prospective registry serum...
Background Increased middle cerebral artery (MCA) blood flow velocities on transcranial duplex sonography (TCD) were recently reported in individual patients after successful mechanical thrombectomy (MT) and related to intracranial hemorrhage poor outcome. However, the retrospective study design of prior studies precluded elucidation underlying pathomechanisms, relationship between TCD brain parenchymal perfusion still remains be determined. Methods We prospectively investigated consecutive...
ABSTRACT Introduction Poststroke epilepsy (PSE) is an important long‐term complication after stroke. Data regarding predictors of PSE in patients with large‐vessel occlusion stroke receiving mechanical thrombectomy (MT) are scarce. Voxel‐based lesion symptom mapping on brain MRI might be a valuable tool the risk prediction PSE. This study aims to assess acute treated MT via voxel‐ and volumetric‐based analyses. Methods In this bi‐center from two tertiary‐care centers, we included consecutive...
BACKGROUND: Atrial fibrillation detected after stroke (AFDAS) affects secondary prevention, yet identification can be challenging. Easily accessible cardiac blood biomarkers such as NT-proBNP (N-terminal pro-B-type natriuretic peptide) could guide diagnostic workup, but optimal cutoff values and the time-dependent relationship between AFDAS are unclear. We aimed (1) to externally validate earlier presented cutoffs for atrial prediction (2) assess of early in-hospital versus discharge....
More than half of the endovascularly treated ischemic stroke patients with incomplete reperfusion (expanded Thrombolysis in Cerebral Infarction [eTICI] <3) show delayed (DR) on 24-hour perfusion imaging, which is associated favorable clinical outcome. The effect intravenous thrombolysis (IVT) rates DR remains unclear. This study aimed to assess treatment IVT occurrence DR. Pooled data from 3 randomized controlled trials (EXTEND-IA and EXTEND-IA TNK parts 1 2) 2 comprehensive centers...
Older adults following recovery from ischemic stroke have a higher incidence of orthostatic hypotension, syncope, and fall risk, which may be related to impaired autonomic responses limiting the ability maintain cerebral blood flow. Thus, we investigated cerebrovascular cardiovascular regulation in 23 ≥55 years age, 10 diagnosed with stroke, 13 age-matched healthy controls when sitting at rest upon standing compare differences variables ∼7 months (218 ± 41 days) poststroke. Arterial pressure...
Abstract Objective To compare two established software applications in terms of apparent diffusion coefficient (ADC) lesion volumes, volume critically hypoperfused brain tissue, and calculated volumes perfusion-diffusion mismatch MRI patients with acute ischemic stroke. Methods Brain examinations 81 stroke due to large vessel occlusion the anterior circulation were analyzed. The ADC volume, automatically different packages. parameters compared quantitatively using formal statistics. Results...
Abstract Background and purpose Clinical outcome after mechanical thrombectomy (MT) for large vessel occlusion (LVO) stroke is influenced by the intracerebral collateral status. We tested hypothesis that patients with preexisting ipsilateral extracranial carotid artery stenosis (CAS) would have a better status compared to non-CAS patients. Additionally, we evaluated MT-related adverse events both groups. Methods Over 7-year period, identified all consecutive anterior circulation MT...
Background and purpose The aim was to investigate the clinical impact of duration artificial ventilation in stroke patients receiving mechanical thrombectomy (MT) under general anaesthesia. Methods All consecutive ischaemic who had been treated at our centre with MT for anterior circulation large vessel occlusion anaesthesia were identified over an 8‐year period. Ventilation time analysed as a continuous variable grouped into extubation within 6 h (‘early’), 6–24 (‘delayed’) >24 (‘late’)....