A5056484950- Glioma Diagnosis and Treatment
- CNS Lymphoma Diagnosis and Treatment
- Cerebrovascular and Carotid Artery Diseases
- Acute Ischemic Stroke Management
- Cardiovascular Disease and Adiposity
- Lymphoma Diagnosis and Treatment
- CRISPR and Genetic Engineering
- Intracranial Aneurysms: Treatment and Complications
- RNA regulation and disease
- Telomeres, Telomerase, and Senescence
- Advanced Neuroimaging Techniques and Applications
- Body Contouring and Surgery
- Brain Metastases and Treatment
- Adipokines, Inflammation, and Metabolic Diseases
- Adipose Tissue and Metabolism
- Morphological variations and asymmetry
- Genetics and Neurodevelopmental Disorders
- Cardiac and Coronary Surgery Techniques
- Prion Diseases and Protein Misfolding
- Body Composition Measurement Techniques
- Neurosurgical Procedures and Complications
- Genetics, Aging, and Longevity in Model Organisms
- Veterinary Oncology Research
- Dementia and Cognitive Impairment Research
- Bone and Joint Diseases
Medical University of Graz
2017-2025
Society of Interventional Radiology
2023
Otto-von-Guericke University Magdeburg
2019
Triemli Hospital
2013
University of Michigan
2001
There are no widely accepted guidelines for the use of recombinant tissue plasminogen activator (rt-PA) in children with acute stroke. We report a single case rt-PA 13-year-old girl hemiplegia. She had history previous stroke, secondary to carotid dissection, and additional stroke risk factors. Treatment IV resulted rapid clinical improvement. Our experience suggests that selected pediatric patients ischemic can be safely administered, this treatment option should considered children. A...
In this study, we assessed the prognostic relevance of temporal muscle thickness (TMT), likely reflecting patient’s frailty, in patients with primary central nervous system lymphoma (PCNSL). 128 newly diagnosed PCNSL TMT was analyzed on cranial magnetic resonance images. Predefined sex-specific cutoff values were used to categorize patient cohort. Survival analyses, using a log-rank test as well Cox models adjusted for further parameters, performed. The risk death significantly increased...
The brain's extracellular matrix (ECM) is assumed to undergo rearrangements in Alzheimer's disease (AD). Here, we investigated changes of key components the hyaluronan-based ECM independent samples post-mortem brains (N = 19), cerebrospinal fluids (CSF; N 70), and RNAseq data 107; from Aging, Dementia TBI Study) AD patients non-demented controls. Group comparisons correlation analyses major soluble synaptosomal fractions frontal, temporal cortex, hippocampus control, low-grade, high-grade...
Abstract Objective To compare two established software applications in terms of apparent diffusion coefficient (ADC) lesion volumes, volume critically hypoperfused brain tissue, and calculated volumes perfusion-diffusion mismatch MRI patients with acute ischemic stroke. Methods Brain examinations 81 stroke due to large vessel occlusion the anterior circulation were analyzed. The ADC volume, automatically different packages. parameters compared quantitatively using formal statistics. Results...
Covert brain infarcts (CBI) are frequent incidental findings on MRI and associated with future stroke risk in patients without a history of clinically evident cerebrovascular events. However, the prognostic value CBI first-ever ischemic is unclear previous studies did not report different etiological subtypes. We aimed to test phenotypes their association recurrence according etiology.
During liver lobectomy, exposure of the hilus may be improved with addition a caudal median sternotomy and diaphragmotomy. This study aimed to report surgical technique for this procedure its clinical outcomes when performed in dogs. The records dogs undergoing lobectomy between 2010 2023 were retrospectively reviewed. Data extracted from these included signalment, preoperative findings, whether was right, central or left divisional, complications, histopathology outcomes. Median survival...
Glioblastoma (GBM) is an utterly devastating cerebral neoplasm and current therapies only marginally improve patients’ overall survival (OS). The PI3K/AKT/mTOR pathway participates in gliomagenesis through regulation of cell growth proliferation. Since it upstream regulator the rate-limiting translation initiation step protein synthesis, controlled by eukaryotic factors (eIFs), we aimed for a profound basic characterization 17 eIFs to identify potential novel therapeutic targets gliomas....
The prognostic roles of clinical and laboratory markers have been exploited to model risk in patients with primary CNS lymphoma, but these approaches do not fully explain the observed variation outcome. To date, neuroimaging or molecular information is used. aim this study was determine utility radiomic features capture clinically relevant phenotypes, link those profiles for enhanced stratification.
<h3>BACKGROUND AND PURPOSE:</h3> Wall enhancement of untreated intracranial aneurysms on MR imaging is thought to predict aneurysm instability. or the cavity in coiled discussed controversially literature regarding potential healing mechanisms adverse inflammatory reactions. Our aim was compare occurrence wall and between completely occluded recanalized after initially complete coil embolization. <h3>MATERIALS METHODS:</h3> In this single-center cross-sectional study, we evaluated successful...
Obesity and metabolic syndrome (MetS) are associated with hypoadiponectinemia. On the contrary, studies revealed correlations between amount of subcutaneous adipose tissue (SAT) higher serum adiponectin levels. Furthermore, independent association intermuscular (IMAT) deposit in thigh cardiometabolic risk factors (including total blood cholesterol, low-density lipoprotein (LDL), triglycerides), decreased insulin sensitivity, as MetS components, sufficiently described. The combined...
Telomeres are a crucial factor in the preservation of genomic integrity, and an elevated risk for diseases such as cancer cardiovascular events is related to shortened telomeres. However, telomere deterioration could be caused by factors chronic oxidative stress inflammation, which promoted imbalance among reactive oxygen species (ROS) antioxidants. In this cross-sectional study, we investigated relationship between telomeres stress. The serum leucocyte telomer length (LTL), total...
Keratin proteins form intermediate filaments, which provide structural support for many tissues. Multiple keratin family members are reported to be associated with the progression of liver disease multiple etiologies. For example, 23 (KRT23) was as a stress-inducible protein, whose expression levels correlate severity disease. Hepatitis C virus (HCV) is human pathogen that causes chronic diseases including fibrosis, cirrhosis, and hepatocellular carcinoma. However, link between KRT23...
Osteocalcin, in its non-carboxylated form, has a positive effect on glucose metabolism. Additionally, osteocalcin levels are related to body composition, especially muscle mass. The relation the distribution of different adipose tissue types, such as subcutaneous, intermuscular, and visceral tissue, is unclear. This study aimed investigate associations between serum subcutaneous intermuscular mid-thigh. Furthermore, influence training methods was investigated. We performed quantification...
Sex-specific differences have been increasingly recognized in many human diseases including brain cancer, namely glioblastoma. Primary CNS lymphoma (PCNSL) is an exceedingly rare type of cancer that tends to a higher incidence and worse outcomes male patients. Yet, relatively little known about the reasons contribute these observed sex-specific differences. Using population-representative cohort patients with PCNSL dense magnetic resonance (MR) imaging digital pathology annotation (n = 74),...
The transcription factor nuclear factor-kappa B (NF-κB) is critically involved in inflammation and cancer development. Activation of NF-κB induces the expression release several pro-inflammatory proteins, which include cytokine interleukin-6 (IL-6). Perturbation actin cytoskeleton has been previously shown to activate signaling. In this study, we analyze influence different compounds that modulate on activation, IL-6 signaling proteolytic generation soluble receptor (sIL-6R) human hepatoma...
Since glioma therapy is currently still limited until today, new treatment options for this heterogeneous group of tumours are great interest. Eukaryotic initiation factors (eIFs) altered in various cancer entities, including gliomas. The purpose our study was to evaluate the potential eIFs as novel targets treatment.We evaluated eIF protein expression and regulation 22 glioblastoma patient-derived xenografts (GBM PDX) after with established cytostatics regards mutation profile analyses GBM...
We present the case of a middle-aged patient who had four recurrent acute basilar artery occlusions over period 3 months, each time successfully treated with mechanical thrombectomy. Extensive stroke work-up showed no obvious etiology aside from dysplastic right vertebral multifocal stenoses. Treatment different antiplatelet and anticoagulant regimes did not prevent occlusion recurrence. Therefore, transarterial coil V4-segment was performed as ultima ratio without complications. At final...
Objectives: Coronary artery bypass graft (CABG) in octogenarians is performed more and frequently, although the operation technique of best benefit unknown. The aim this retrospective study was to compare results CABG using beating heart on cardiopulmonary or off-pump coronary surgery (OPCAB).
Abstract Short-chain fatty acids (SCFAs) are circulating metabolites generated by gut microbiota. Recently, a link between age-related muscle loss and microbiota has been described, SCFAs could play mediating role in this relationship. Acetic, propionic, butyric acid the abundant forms considered to have health benefits, less is known about valeric caproic acid. In cross-sectional study including 155 healthy volunteers, we investigated relationship area, as well intramuscular adipose tissue...
Telomeres are DNA-protein complexes at the ends of linear chromosomes that protect against DNA degradation. shorten during normal cell divisions and therefore, telomere length is an indicator mitotic-cell age. In humans, shortening a potential biomarker for disease risk, progression premature death. Physical activity has been associated with longer leukocyte (LTL) in some studies. current study relationship between LTL, thigh muscle mass adipose tissue distribution was explored.
Background: The prognostic roles of clinical and laboratory markers have been exploited to model risk in patients with primary CNS lymphoma (PCNSL), but these approaches do not fully explain the observed variation outcome. Here we present an extended framework phenotype-epigenotype correlations that reveal novel constellations enable prioritizing epigenetic therapy. Methods: In this retrospective discovery validation study, strike a balance between radiomic feature-driven analysis medical...