A5007534010- Superconducting and THz Device Technology
- Physics of Superconductivity and Magnetism
- Particle Detector Development and Performance
- Radio Frequency Integrated Circuit Design
- Microwave Engineering and Waveguides
- 3D IC and TSV technologies
- Analog and Mixed-Signal Circuit Design
- Quantum and electron transport phenomena
- Neutrino Physics Research
- Venous Thromboembolism Diagnosis and Management
- Advanced X-ray Imaging Techniques
- CCD and CMOS Imaging Sensors
- Nuclear Physics and Applications
- Dark Matter and Cosmic Phenomena
- Advanced Semiconductor Detectors and Materials
- Particle accelerators and beam dynamics
- Acute Ischemic Stroke Management
- Particle physics theoretical and experimental studies
- Atrial Fibrillation Management and Outcomes
- Antenna Design and Optimization
- X-ray Spectroscopy and Fluorescence Analysis
- Industrial Gas Emission Control
- Odor and Emission Control Technologies
- Magnetic Field Sensors Techniques
- Real-time simulation and control systems
University of Helsinki
2024
Helsinki University Hospital
2024
Heidelberg University
2014-2023
University of Pennsylvania Press
2002-2023
Kirchhoff (Germany)
2017-2023
University of Pennsylvania
2002-2008
ETH Zurich
1993
Thrombosis of cerebral veins and sinus (cerebral venous thrombosis) is a rare stroke pathogenesis. Pharmaceutical treatment restricted to heparin oral anticoagulation with vitamin K antagonists (VKAs).Between January 2012 December 2013, we recorded data from our patients thrombosis. The modified Rankin scale was used assess clinical severity; excellent outcome defined as 0 1. Recanalization assessed on follow-up MR angiography. Patients were then divided into 2 groups: phenprocoumon (VKA)...
Whether infarct size modifies the treatment effect of early vs late direct oral anticoagulant (DOAC) initiation in people with ischemic stroke and atrial fibrillation is unknown.
We report on the first demonstration of a scalable GHz frequency-domain readout metallic magnetic calorimeters (MMCs) using 64 pixel detector array that is read out by an integrated, on-chip microwave SQUID multiplexer. The optimized for detecting soft X-ray photons and multiplexer designed to provide signal rise time τrise<400ns intrinsic energy sensitivity ϵ<30h. This results in expected resolution ΔEFWHM<10eV. measured τrise as low 90ns ΔEFWHM 50eV 5.9keV photons....
Abstract The determination of the effective electron neutrino mass via kinematic analysis beta and capture spectra is considered to be model-independent since it relies on energy momentum conservation. At same time precise description expected spectrum goes beyond simple phase space term. In particular for processes, many-body electron-electron interactions lead additional structures besides main resonances in calorimetrically measured spectra. A $$^{163}$$ <mml:math...
Importance The net clinical effect of early vs later direct oral anticoagulant (DOAC) initiation after atrial fibrillation–associated ischemic stroke is unclear. Objective To investigate whether DOAC treatment associated with a benefit (NCB). Design, Setting, and Participants This was post hoc analysis the Early Versus Late Initiation Direct Oral Anticoagulants in Post–Ischaemic Stroke Patients With Atrial Fibrillation (ELAN) open-label randomized trial conducted across 103 sites 15...
We report on the design, fabrication and characterization of a 64 pixel metallic magnetic calorimeter array that is read out by an integrated, on-chip microwave SQUID multiplexer. Based results our comprehensive device we refined state-of-the-art multiplexer model which assumes each associated non-hysteretic rf-SQUID to purely behave as flux-dependent inductor. In particular, include capacitance subgap resistance Josephson junction well screening effects parasitic mutual couplings between...
Abstract Due to their excellent energy resolution, the intrinsically fast signal rise time, huge dynamic range, and almost ideally linear detector response, metallic magnetic calorimeters (MMC)s are very well suited for a variety of applications in physics. In particular, ECHo experiment aims utilize large-scale MMC-based arrays investigate mass electron neutrino. Reading out such is challenging task which can be tackled using microwave SQUID multiplexing. Here, signals transduced into...
This paper will describe the use of through-silicon vias (TSVs) in a readout application-specific integrated circuit (ASIC) chip to replace wire bonds assembly cadmium zinc telluride (CZT) X-ray detector arrays for space telescope applications. The TSV packaging approach includes solder bump connections from back ASIC underlying board. greatly reduce spacing between adjacent detectors an array, eliminate potential damage wires during assembly, and avoid any interference, which can pick up...
Due to the periodic characteristics of SQUIDs, a suitable linearization technique is required for SQUID-based readout. Flux-ramp modulation common and typically applied readout microwave-SQUID-multiplexer as well since recently also dc-SQUIDs. requires another stage in signal processing chain demodulate SQUID output before further processing. For cryogenic microcalorimenters, these events are given by fast exponentially rising slowly decaying pulses which shall be detected trigger engine...
Metallic magnetic micro-calorimeters (MMCs) operated at millikelvin temperature offer the possibility to achieve eV-scale energy resolution with high stopping power for X-rays and massive particles in an range up several tens of keV. This motivates their use a wide applications fields as particle physics, atomic molecular physics. Present detector systems consist MMC arrays read out by 32 two-stage SQUID read-out channels. In contrast design array consequently front-end SQUIDs, which need be...
We present a MHz frequency-division direct-current superconducting quantum interference device (dc-SQUID) multiplexer that is based on flux ramp modulation and series array of N identical current-sensing dc-SQUIDs with tightly coupled input coil. By running periodic, sawtooth-shaped current signal through additional coils being but non-uniformly to the individual SQUIDs, voltage drop across changes according sum flux-to-voltage characteristics SQUIDs within each cycle signal. In this mode...
Application-specific integrated circuits (ASICs) are commonly used to efficiently process the signals from sensors and detectors in space. Wire bonding is a space-qualified technique of making interconnections between ASICs their substrate packaging board for power, control, readout ASICs. nearly ubiquitous modern space programs, but exposed wires can be prone damage during assembly subject electric interference operations. Additional around needed wire also impedes efficient large arrays...
The definition of the absolute neutrino mass scale is one main goals Particle Physics today. study end-point regions $\beta$- and electron capture (EC) spectrum offers a possibility to determine effective (anti-)neutrino in completely model independent way, as it only relies on energy momentum conservation. ECHo (Electron Capture $^{163}$Ho) experiment has been designed attempt measure by performing high statistics resolution measurements $^{163}$Ho spectrum. To achieve this goal, large...
Magnetic microcalorimeters (MMCs) are cryogenic, energy-dispersive single-particle detectors providing excellent energy resolution, intrinsically fast signal rise time, quantum efficiency close to 100\%, large dynamic range as well almost ideal linear response. One of the remaining challenges be overcome ultimately allow for utilization large-scale MMC based detector arrays with thousands millions individual pixels is realization a SQUID multiplexing technique particularly tailored readout....