Peter Vanacker
A5077453387- Acute Ischemic Stroke Management
- Atrial Fibrillation Management and Outcomes
- Cerebrovascular and Carotid Artery Diseases
- Venous Thromboembolism Diagnosis and Management
- Stroke Rehabilitation and Recovery
- Cardiac Arrhythmias and Treatments
- Traumatic Brain Injury and Neurovascular Disturbances
- Antiplatelet Therapy and Cardiovascular Diseases
- Neurological Disorders and Treatments
- Cardiac electrophysiology and arrhythmias
- Cardiac Imaging and Diagnostics
- Lipoproteins and Cardiovascular Health
- COVID-19 and healthcare impacts
- Intracerebral and Subarachnoid Hemorrhage Research
- Health Systems, Economic Evaluations, Quality of Life
- Cardiovascular and Diving-Related Complications
- Long-Term Effects of COVID-19
- Healthcare Systems and Practices
- Climate Change and Health Impacts
- Protease and Inhibitor Mechanisms
- Amyotrophic Lateral Sclerosis Research
- Neurological Complications and Syndromes
- Pericarditis and Cardiac Tamponade
- Intracranial Aneurysms: Treatment and Complications
- Cerebrospinal fluid and hydrocephalus
Antwerp University Hospital
2016-2025
University of Antwerp
2019-2025
AZ Groeninge
2019-2025
University Hospital of Lausanne
2014-2024
Mater Misericordiae University Hospital
2023-2024
University College Dublin
2023-2024
Laboratoire Lorrain de Recherche en Informatique et ses Applications
2023
Boston Medical Center
2021-2022
Boston University
2021-2022
Ghent University Hospital
2022
Recently, mutations in the progranulin (PGRN) gene were found to cause familial and apparently sporadic frontotemporal lobe dementia (FTLD). Moreover, missense changes PGRN identified patients with motor neuron degeneration, a condition that is related FTLD. Most FTLD until now have been null mutations. However, it remains unknown whether protein levels are reduced central nervous system from such patients. The effects of on neurons also remain be established. We report cerebrospinal fluid...
Background and Purpose— The best time for administering anticoagulation therapy in acute cardioembolic stroke remains unclear. This prospective cohort study of patients with atrial fibrillation, evaluated (1) the risk recurrent ischemic event severe bleeding; (2) factors recurrence (3) risks bleeding associated anticoagulant its starting after stroke. Methods— primary outcome this multicenter was composite stroke, transient attack, symptomatic systemic embolism, cerebral major extracranial...
Ischemic stroke is caused by a thromboembolic occlusion of cerebral arteries. Treatment focused on fast and efficient removal the occluding thrombus, either via intravenous thrombolysis or endovascular thrombectomy. Recanalization, however, not always successful factors contributing to failure are completely understood. Although thrombus primary target acute treatment, little known about its internal organization composition. The aim this study, therefore, was better understand ischemic...
To measure the global impact of COVID-19 pandemic on volumes IV thrombolysis (IVT), IVT transfers, and stroke hospitalizations over 4 months at height (March 1 to June 30, 2020) compared with 2 control 4-month periods.We conducted a cross-sectional, observational, retrospective study across 6 continents, 70 countries, 457 centers. Diagnoses were identified by their ICD-10 codes or classifications in databases.There 91,373 admissions immediately before 80,894 during months, representing an...
The effect of early as compared with later initiation direct oral anticoagulants (DOACs) in persons atrial fibrillation who have had an acute ischemic stroke is unclear.We performed investigator-initiated, open-label trial at 103 sites 15 countries. Participants were randomly assigned a 1:1 ratio to anticoagulation (within 48 hours after minor or moderate on day 6 7 major stroke) (day 3 4 stroke, 12, 13, 14 stroke). Assessors unaware the trial-group assignments. primary outcome was composite...
Among patients with a transient ischemic attack or minor strokes, those ipsilateral atherosclerotic stenosis of cervicocranial vasculature have the highest risk recurrent vascular events.
In patients with atrial fibrillation who suffered an ischemic stroke while on treatment nonvitamin K antagonist oral anticoagulants, rates and determinants of recurrent events major bleedings remain uncertain.This prospective multicenter observational study aimed to estimate the bleeding their in follow-up consecutive acute cerebrovascular event anticoagulant treatment. Afterwards, we compared estimated risks between whom therapy was changed those continued original treatment.After a mean...
Resistance to r-tPA (recombinant tissue-type plasminogen activator) is a well-known but poorly understood phenomenon that hampers successful recanalization in patients with acute ischemic stroke. Using clinically relevant thrombi from stroke, we investigated if and how thrombus composition impacts r-tPA-mediated lysis. In addition, explored strategies overcome resistance.
Background In patients with acute ischemic stroke and atrial fibrillation, early anticoagulation prevents recurrence but the risk of hemorrhagic transformation ( HT ). The aims this study were to evaluate in consecutive fibrillation (1) incidence HT, (2) time initiation , (3) association recurrences, (4) clinical outcome at 90 days. Methods Results was diagnosed by a second brain computed tomographic scan performed 24 72 hours after onset. recurrences as well mortality or disability...
Endovascular treatment (EVT) is a new standard of care for selected, large vessel occlusive strokes. We aimed to determine frequency potentially eligible patients intravenous thrombolysis (IVT) and EVT in comprehensive stroke centers. In addition, predictors eligibility were derived.Patients from center-based registry (2003-2014), admitted within 24 hours last proof usual health, selected if they had all data IVT according American Heart Association/American Stroke Association (AHA/ASA)...
<h3>Background and Objectives</h3> Declines in stroke admission, IV thrombolysis (IVT), mechanical thrombectomy volumes were reported during the first wave of COVID-19 pandemic. There is a paucity data on longer-term effect pandemic over course year through second We sought to measure admissions, intracranial hemorrhage (ICH), IVT, 1-year period at onset (March 1, 2020, February 28, 2021) compared with immediately preceding 2019, 29, 2020). <h3>Methods</h3> conducted longitudinal...
We assessed best available data on access and delivery of acute stroke unit (SU) care, intravenous thrombolysis (IVT) endovascular treatment (EVT) in the European region 2019 2020.We compared national per number inhabitants 100 annual incident first-ever ischaemic strokes (AIIS) 46 countries. Population estimates incidence were based United Nations Global Burden Disease Report 2019, respectively.The estimated mean SUs was 3.68 (95% CI: 2.90-4.45) one million (MIH) with 7/44 countries having...
Frontotemporal lobar degeneration (FTLD) and amyotrophic lateral sclerosis (ALS) are overlapping neurodegenerative disorders. Mutations in the growth factor progranulin (PGRN) gene cause FTLD, sometimes conjunction with ALS; such mutations also observed some ALS patients. Most PGRN underlying FTLD null that result reduced levels. We investigated expression human mouse models of motor neuron degeneration. Progranulin plasma or CSF levels newly diagnosed patients did not differ from those...
Endovascular treatment for acute ischemic stroke with a large vessel occlusion was recently shown to be effective. We aimed develop score capable of predicting eligible endovascular in the early hospital management.Retrospective, cohort study.Two tertiary, Swiss centers.Consecutive patients (1,645 patients; Acute STroke Registry and Analysis Lausanne registry), who had CT angiography within 6 12 hours symptom onset, were categorized according site. Demographic clinical information used...
Achieving first-pass recanalization (FPR) has become the primary procedural objective during thrombectomy in acute ischemic stroke patients as it correlates with best clinical outcome. Understanding factors contributing to FPR failures is essential enhance success rates. As central target of thrombectomy, thrombus itself may be a significant factor influencing FPR.
Reduction of subsequent disabling stroke is the main goal preventive treatment in acute setting after transient ischemic attack (TIA) or minor stroke.
The real-life application of DAWN and DEFUSE-3 trials has been poorly investigated. We aimed to identify the proportion patients with acute ischemic stroke (AIS) eligible for late endovascular treatment (EVT) in our center based on trial more liberal selection criteria.All consecutive registry (2003-2017) admitted within 5-23 hours last proof good health were selected if they had complete clinical radiological datasets. calculated EVT according (DAWN and/or DEFUSE-3) clinical/imaging...
This study was designed to derive and validate a score predict early ischemic events major bleedings after an acute stroke in patients with atrial fibrillation.The derivation cohort consisted of 854 fibrillation included prospective series between January 2012 March 2014. Older age (hazard ratio 1.06 for each additional year; 95% confidence interval, 1.00-1.11) severe enlargement ratio, 2.05; 1.08-2.87) were predictors outcome (stroke, transient attack, systemic embolism) at 90 days from...
Background and Purpose— Bridging therapy with low-molecular-weight heparin reportedly leads to a worse outcome for acute cardioembolic stroke patients because of higher incidence intracerebral bleeding. However, this practice is common in clinical settings. This observational study aimed compare (1) the profiles receiving not bridging therapy, (2) overall group outcomes, (3) outcomes according type anticoagulant prescribed. Methods— We analyzed data from prospective RAF RAF-NOACs studies....
Introduction: The efficacy and safety of statins for secondary prevention in patients who have experienced a cardioembolic stroke are not well-defined. However, previous observational data reported hyperlipidemia as risk factor both ischemic bleeding complications with AF stroke. Based on these premises, we conducted sub-analysis the RAF RAF-NOAC studies to evaluate acute AF. Materials methods: We combined patient from studies, prospective across Stroke Units Europe, United States, Asia...