Federica Letteri
A5060076631- Acute Ischemic Stroke Management
- Atrial Fibrillation Management and Outcomes
- Venous Thromboembolism Diagnosis and Management
- Cerebrovascular and Carotid Artery Diseases
- Traumatic Brain Injury and Neurovascular Disturbances
- Intracerebral and Subarachnoid Hemorrhage Research
- Antiplatelet Therapy and Cardiovascular Diseases
- Lipoproteins and Cardiovascular Health
- Cardiac Arrhythmias and Treatments
- Trauma and Emergency Care Studies
- Migraine and Headache Studies
- Dementia and Cognitive Impairment Research
- Cardiac pacing and defibrillation studies
- Viral Infections and Immunology Research
- Pharmacological Effects and Toxicity Studies
- Neurogenesis and neuroplasticity mechanisms
- Cardiac Imaging and Diagnostics
- Health, Environment, Cognitive Aging
- Restraint-Related Deaths
- Retinal and Optic Conditions
- Ocular Diseases and Behçet’s Syndrome
- Alzheimer's disease research and treatments
- Glaucoma and retinal disorders
- Restless Legs Syndrome Research
- Sleep and Wakefulness Research
Sapienza University of Rome
2013-2024
Ospedale del Ceppo
2021-2024
Azienda Ospedaliera Nazionale SS. Antonio e Biagio e Cesare Arrigo
2023
Ospedale Sacro Cuore Don Calabria
2020
Istituti di Ricovero e Cura a Carattere Scientifico
2020
Policlinico Umberto I
2017-2019
University of Calgary
2019
St. Anne's University Hospital Brno
2017
University Hospital of Alexandroupolis
2017
Democritus University of Thrace
2017
Background The optimal timing to administer non–vitamin K oral anticoagulants ( NOAC s) in patients with acute ischemic stroke and atrial fibrillation is unclear. This prospective observational multicenter study evaluated the rates of early recurrence major bleeding (within 90 days) their who received s for secondary prevention. Methods Results Recurrence was defined as composite stroke, transient attack, symptomatic systemic embolism, cerebral extracranial bleeding. For analysis, 1127 were...
Background In patients with acute ischemic stroke and atrial fibrillation, early anticoagulation prevents recurrence but the risk of hemorrhagic transformation ( HT ). The aims this study were to evaluate in consecutive fibrillation (1) incidence HT, (2) time initiation , (3) association recurrences, (4) clinical outcome at 90 days. Methods Results was diagnosed by a second brain computed tomographic scan performed 24 72 hours after onset. recurrences as well mortality or disability...
Randomized controlled trials (RCTs) proved that short-term (21-90 days) dual antiplatelet therapy (DAPT) reduces the risk of early ischemic recurrences after a noncardioembolic minor stroke or high-risk transient attack (TIA) without substantially increasing hemorrhagic risk. We aimed at understanding whether and how real-world use DAPT differs from RCTs.READAPT (Real-Life Study on Short-Term Dual Antiplatelet Treatment in Patients With Ischemic Stroke TIA) is prospective cohort study...
Background and Purpose: There is interest in what happens over time to the thrombus after intravenous alteplase. We study effect of alteplase on structure its impact clinical outcome patients with acute stroke. Methods: Intravenous treated stroke intracranial internal carotid artery or middle cerebral occlusion identified baseline computed tomography angiography follow-up vascular imaging (computed first run before endovascular therapy) were enrolled from INTERRSeCT (Identifying New...
This study was designed to derive and validate a score predict early ischemic events major bleedings after an acute stroke in patients with atrial fibrillation.The derivation cohort consisted of 854 fibrillation included prospective series between January 2012 March 2014. Older age (hazard ratio 1.06 for each additional year; 95% confidence interval, 1.00-1.11) severe enlargement ratio, 2.05; 1.08-2.87) were predictors outcome (stroke, transient attack, systemic embolism) at 90 days from...
Background and Purpose— Bridging therapy with low-molecular-weight heparin reportedly leads to a worse outcome for acute cardioembolic stroke patients because of higher incidence intracerebral bleeding. However, this practice is common in clinical settings. This observational study aimed compare (1) the profiles receiving not bridging therapy, (2) overall group outcomes, (3) outcomes according type anticoagulant prescribed. Methods— We analyzed data from prospective RAF RAF-NOACs studies....
Background: Restless legs syndrome (RLS) is a neurological disorder characterized by the urge to move associated with peculiar unpleasant sensations during periods of rest and inactivity that are relieved movement. A few studies analyzed RLS in neurodegenerative diseases such as Alzheimer's Disease (AD). The aim our study was assess prevalence clinical characteristics cohort AD patients. Methods: Three hundred thirty-nine subjects diagnosis were recruited. Cognitive, functional,...
Alzheimer's disease (AD), the most common cause of dementia, typically shows a slow clinical progression over time. 'Rapidly progressive' AD, variant characterized by an aggressive course, exhibits distinct clinical, biological, and neuropathological features. Here, we investigate neuropsychological predictors rapid decline in group mild patients with AD.One hundred fifty-three AD admitted to memory disorder clinic followed for up 3 years were included this study. A comprehensive (NP)...
Abstract Background and purpose The ANNEXA‐4 trial measured hemostatic efficacy of andexanet alfa in patients with major bleeding taking factor Xa inhibitors. A proportion this was traumatic nontraumatic intracranial bleeding. Different measurements were applied the including volumetrics to assess for depending on compartment involved. We aimed determine most reliable way measure hemorrhage (ICrH) volume by comparing individual brain total ICrH volume. Methods Thirty randomly selected from...
Background Acute stroke patients with comorbid cancer (CC) are more preferably addressed endovascular treatment (EVT) than thrombolytic therapy, due to the presumed potential risk of hemorrhagic transformation and systemic bleeding. This study aims evaluate clinical procedural outcomes acute CC receiving EVT. Methods Using Italian Registry Endovascular Treatment in Stroke, we reviewed prospectively collected data treated EVT from 2011 2017. Outcome measures were modified Thrombolysis...
Alice in Wonderland Syndrome (AIWS) is a rare perceptual disorder characterized by an erroneous perception of the body or surrounding space. AIWS may be caused different pathologies, ranging from infections to migraine. We present case 54-year-old man, with long-time history migraine without aura, diagnosed due glioblastoma located left temporal–occipital junction. To date, this first glioblastoma. This suggests that exclude aura-mimic phenomena, careful diagnostic workup should always...
The aim of this study in patients with acute posterior ischaemic stroke (PS) and atrial fibrillation (AF) was to evaluate (1) the risks recurrent event severe bleeding (2) these relation oral anticoagulant therapy (OAT) its timing. Patients PS were prospectively included; outcome events compared those anterior (AS) which taken from previous registries. primary composite recurrence, transient attack, symptomatic systemic embolism, cerebral major extracranial occurring within 90 days stroke. A...
Background and Purpose: The optimal timing for starting oral anticoagulant after an ischemic stroke related to atrial fibrillation remains a challenge, mainly in patients treated with systemic thrombolysis or mechanical thrombectomy. We aimed at assessing the incidence of early recurrence major bleeding acute thrombolytic therapy and/or thrombectomy, who then received anticoagulants secondary prevention. Methods: combined dataset RAF RAF-NOACs (Early Recurrence Major Bleeding Patients With...
Background and Purpose- Prognostic value of copeptin in acute ischemic stroke has been widely reported. This study aimed to evaluate temporal profile according revascularization strategies the development brain edema hemorrhagic transformation. Methods- Plasma transformation assessed by computed tomography/magnetic resonance imaging were evaluated upon admission (T0), at 24 hours (T1), between third fifth day hospitalization (T2) 34 patients. Results- Median concentration was 50.71 pmol/L...
The relationship between different patterns of atrial fibrillation and early recurrence after an acute ischaemic stroke is unclear. In a prospective cohort study, we evaluated the rates in patients with paroxysmal or sustained which included persistent permanent fibrillation. stroke, was categorised as Ischaemic recurrences were composite transient attack symptomatic systemic embolism occurring within 90 days from index stroke. A total 2150 (1155 females, 53.7%) enrolled: 930 (43.3%) had...
The widespread use of direct oral anticoagulants (DOACs) has been increasing the conditions in which emergency physicians are forced to rapidly reverse anticoagulation case life-threatening bleeding or need urgent surgery invasive procedures. recent approval Idarucizumab, a humanized monoclonal antibody fragment (Fab), offered opportunity and safely neutralize anticoagulant effect Dabigatran. However, real-world experience its effective different setting is now required. Lumbar Puncture (LP)...
A Peruvian woman was admitted to the Emergency Department, due an acute flaccid paralysis (AFP) of upper limbs that progressively involved also lower and respiratory muscles. She previously suffered from non-Hodgkin's lymphoma had undergo hematopoietic stem cell transplantation. magnetic resonance imaging showed a T2 hyperintensity in anterior central region cervical segment with elective involvement gray matter. This finding, combined other clinical, laboratory, electrophysiological data,...