Valentina Puglisi
A5035451413- Cerebrovascular and Carotid Artery Diseases
- Acute Ischemic Stroke Management
- Transcranial Magnetic Stimulation Studies
- Antiplatelet Therapy and Cardiovascular Diseases
- Diverse academic and cultural studies
- Long-Term Effects of COVID-19
- Neurological Disorders and Treatments
- Management, Economics, and Public Policy
- Migraine and Headache Studies
- COVID-19 and healthcare impacts
- Urban Planning and Valuation
- Venous Thromboembolism Diagnosis and Management
- Neurological Disease Mechanisms and Treatments
- Dementia and Cognitive Impairment Research
- Functional Brain Connectivity Studies
- Neurological disorders and treatments
- Genetic Neurodegenerative Diseases
- Pituitary Gland Disorders and Treatments
- Cardiovascular Health and Disease Prevention
- Stroke Rehabilitation and Recovery
- Peripheral Nerve Disorders
- Retinal and Optic Conditions
- Intramuscular injections and effects
- Pain Management and Treatment
- Cerebral Venous Sinus Thrombosis
Istituti Ospitalieri di Cremona
2020-2025
Azienda Socio Sanitaria Territoriale di Cremona
2020-2025
Azienda Ospedaliera Ospedale Maggiore
2025
Ospedale Santa Corona
2020
Azienda Socio Sanitaria Territoriale Lariana
2020
Centro Neurolesi Bonino Pulejo
2018-2019
Fondazione Istituto G. Giglio di Cefalù
2018-2019
University of Catania
2011-2015
We aimed to investigate the rate of hospital admissions for cerebrovascular events and revascularization treatments acute ischemic stroke in Italy during coronavirus disease 2019 (COVID-19) outbreak.
Background Although cerebral white matter lesions (WMLs) are considered as a risk factor for vascular dementia, data on their impact hemodynamics scarce. We test and compare transcranial Doppler (TCD) features in WML patients with or without associated cognitive impairment. Methods A sample of non-demented elderly WMLs was consecutively recruited. Mean blood flow velocity (MBFV), pulsatility index (PI), peak systolic (PSV), end-diastolic (EDV), resistivity (RI) were recorded from the middle...
Motor evoked potentials (MEPs) to transcranial magnetic stimulation (TMS) are known be susceptible several sources of variability. However, conflicting evidences on individual characteristics in relatively small sample sizes have been reported. We investigated the effect age, height, and sex MEPs motor cortex spinal roots a large cohort.A total 587 subjects clinically neuroradiologically intact were included. recorded during mild tonic contraction through circular coil applied over "hot...
Randomized controlled trials (RCTs) proved that short-term (21-90 days) dual antiplatelet therapy (DAPT) reduces the risk of early ischemic recurrences after a noncardioembolic minor stroke or high-risk transient attack (TIA) without substantially increasing hemorrhagic risk. We aimed at understanding whether and how real-world use DAPT differs from RCTs.READAPT (Real-Life Study on Short-Term Dual Antiplatelet Treatment in Patients With Ischemic Stroke TIA) is prospective cohort study...
Introduction Celiac disease (CD) may initially present as a neurological disorder or be complicated by changes. To date, neurophysiological studies aiming to an objective evaluation of the potential central nervous system involvement in CD are lacking. Objective assess profile cortical excitability Transcranial Magnetic Stimulation (TMS) group de novo patients. Materials and methods Twenty patients underwent screening for cognitive neuropsychiatric symptoms means Mini Mental State...
Introduction: late-life depression is a well-known risk factor for future dementia. Increasing evidences also show link between cerebral hypoperfusion and neurodegeneration, although data on Transcranial Doppler ultrasonography (TCD)-derived measures in patients with "Vascular Depression" (VD) are lacking. The aim of this study was to assess correlate TCD parameters cognitive function severity subcortical ischemic vascular disease sample VD patients. Methods: 76 (mean age 72.5 ± 5.3 years;...
Randomized controlled trials (RCTs) proved the efficacy of short-term dual antiplatelet therapy (DAPT) in secondary prevention minor ischemic stroke or high-risk transient attack (TIA). We aimed at evaluating effectiveness and safety DAPT real-world, where treatment use is broader than RCTs.
Background The optimal treatment for acute minor ischemic stroke is still undefined. and options include dual antiplatelet (DAPT), intravenous thrombolysis (IVT), or their combination. We aimed to investigate benefits risks of combining IVT DAPT versus alone in patients with MIS. Methods Results This a prespecified propensity score‐matched analysis from prospective multicentric real‐world study (READAPT [Real‐Life Study on Short‐Term Dual Antiplatelet Treatment Patients With Ischemic Stroke...
An imbalance between excitatory and inhibitory synaptic excitability was observed in de novo patients with celiac disease (CD) a previous study Transcranial Magnetic Stimulation (TMS), suggesting subclinical involvement of GABAergic glutamatergic neurotransmission asymptomatic patients. The aim this investigation to monitor the eventual changes same cohort patients, evaluated after period gluten-free diet.Patients were re-evaluated median 16 months during which an adequate diet maintained....
Background To date, few data to transcranial Doppler sonography (TCD) are available in patients with mild vascular cognitive impairment (VCI) at risk for or mixed dementia. In a previous study VCI and cerebral small vessels disease, hemodynamic pattern of hypoperfusion enhanced resistance were observed; however, longitudinal currently lacking. Here, we perform clinical, psychopathological, neurosonological follow-up order monitor any progression identify TCD measures detect it. Methods From...
ABSTRACT Background and Aim According to randomized controlled trials (RCTs), dual antiplatelet therapy (DAPT) is more effective for secondary prevention of ischemic events attributable large artery atherosclerosis (LAA) than other mechanisms. We investigated whether real‐world application may impact DAPT effectiveness safety in the REAl‐life study on short‐term Dual Antiplatelet treatment Patients with stroke or Transient attack (READAPT, NCT05476081). Methods READAPT was an observational...
Introduction: Patients with ischemic stroke or transient attack (TIA) and cancer face unique risks of recurrent events bleeding. It is unclear whether this increased risk present even in patients minor receiving dual antiplatelet therapy (DAPT). This study aimed to evaluate the impact on short-term outcomes after DAPT non-cardioembolic high-risk TIA. methods: was a secondary analysis prospective multicentric READAPT (NCT05476081), including (NIHSS ⩽ 5) TIA (ABCD2 ⩾4) who initiated within 48...
Elevated baseline systolic blood pressure (SBP) was associated with poor outcomes following dual antiplatelet therapy (DAPT) in patients non-cardioembolic minor ischemic stroke (MIS) or high-risk transient attack (TIA) clinical trials. We aimed to assess the impact of admission SBP on short-term after DAPT MIS TIA. performed an inverse probability weighted (IPW) analysis from a prospective multicentric real-world study (READAPT) including (National Institute Health Stroke Scale 0-5) TIA...
Patients with Fabry's disease (FD) may be asymptomatic or show a spectrum of clinical manifestations, including cerebrovascular disease, mainly affecting posterior circulation. Few and conflicting studies on cerebral blood flow (CBF) velocity by transcranial Doppler sonography (TCD) in FD (aFD) subjects have been published. Our study aims to assess TCD aFD identify any preclinical CBF change.A total 30 were consecutively recruited compared 28 healthy controls. Brain magnetic resonance...
Migrainous infarction (MI) is a rare complication of migraines that accounts for 0.5-1.5% all ischemic strokes. Although the pathogenesis MI still debated, cortical spreading depression and consequent biochemical cascade hemodynamic changes are presumed to play an important role. Here we describe case systematically review literature on complex possibly bidirectional relationship between migraine stroke. A 44-year-old female with history visual aura presented at Emergency Department due...
ABSTRACT BACKGROUND AND PURPOSE While AD can be definitively confirmed by postmortem histopathologic examination, in vivo imaging may improve the clinician's ability to identify at earliest stage. The aim of study was test performance amyloid PET using new processing algorithm for more precise diagnosis AD. METHODS Amyloid results a (MRI‐Less and AAL Atlas) were correlated with clinical, cognitive status, CSF analysis, other imaging. regional SUVR white matter cerebellum as reference region...
While the association between motor-evoked potential (MEP) abnormalities and motor deficit is well established, few studies have reported correlation MEPs signs of pyramidal tract dysfunction without weakness. We assessed in patients with signs, including deficits, compared to but weakness.Forty-three cervical spondylotic myelopathy (CSM) were dichotomized into 21 (Group 1) 22 normal strength 2), both groups 33 healthy controls 0). bilaterally recorded from first dorsal interosseous tibialis...