A5087210151- Mitochondrial Function and Pathology
- ATP Synthase and ATPases Research
- Metabolism and Genetic Disorders
- Acute Ischemic Stroke Management
- Muscle Physiology and Disorders
- Cerebrovascular and Carotid Artery Diseases
- Cerebrovascular and genetic disorders
- Moyamoya disease diagnosis and treatment
- Migraine and Headache Studies
- Genetic Neurodegenerative Diseases
- Neurological diseases and metabolism
- Blood Coagulation and Thrombosis Mechanisms
- Skin and Cellular Biology Research
- Venous Thromboembolism Diagnosis and Management
- Intracranial Aneurysms: Treatment and Complications
- RNA and protein synthesis mechanisms
- Cerebral Venous Sinus Thrombosis
- Neurology and Historical Studies
- Inflammatory Myopathies and Dermatomyositis
- Cardiovascular Issues in Pregnancy
- Peripheral Neuropathies and Disorders
- Intracerebral and Subarachnoid Hemorrhage Research
- Hereditary Neurological Disorders
- Metalloenzymes and iron-sulfur proteins
- Apelin-related biomedical research
Ospedale Valduce
1999-2021
Azienda Ospedaliera Sant'Andrea
2014-2016
University of Pavia
2014-2016
University of Brescia
2014-2016
Istituti di Ricovero e Cura a Carattere Scientifico
2016
Azienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia
2014
Columbia University
2000-2006
University of Milan
1991-1999
University of Messina
1993
Background— Data on long-term risk and predictors of recurrent thrombotic events after ischemic stroke at a young age are limited. Methods Results— We followed 1867 patients with first-ever who were 18 to 45 years (mean age, 36.8±7.1 years; women, 49.0%), as part the Italian Project Stroke in Young Adults (IPSYS). Median follow-up was 40 months (25th 75th percentile, 53). The primary end point composite stroke, transient attack, myocardial infarction, or other arterial events. One hundred...
We screened 41 patients with undiagnosed encephalomyopathies and cytochrome c oxidase (COX) deficiency for mutations in two COX assembly genes, SURF-1 SCO2; 6 had 3 SCO2. All of the were small-scale rearrangements (deletions/insertions); homozygotes other compound heterozygotes. SCO2 heterozygotes nonsense or missense mutations. Leigh syndrome, whereas a combination encephalopathy hypertrophic cardiomyopathy, neuropathology did not show typical features syndrome. In mutations, onset was...
<h3>Importance</h3> Although sparse observational studies have suggested a link between migraine and cervical artery dissection (CEAD), any association the 2 disorders is still unconfirmed. This lack of definitive conclusion might implications in understanding pathogenesis both conditions complex relationship ischemic stroke (IS). <h3>Objective</h3> To investigate whether history its subtypes associated with occurrence CEAD. <h3>Design, Setting, Participants</h3> A prospective cohort study...
We aimed to investigate the rate of hospital admissions for cerebrovascular events and revascularization treatments acute ischemic stroke in Italy during coronavirus disease 2019 (COVID-19) outbreak.
Several lines of evidence support the involvement lectin pathway complement (LP) in pathogenesis acute ischemic stroke. The aim this multicenter observational study was to assess prognostic value different circulating LP initiators Plasma levels ficolin-1, -2, and -3 mannose-binding (MBL) were measured 80 stroke patients at 6 h only 85 48 later. Sixty-one age- sex-matched healthy individuals served as controls. Stroke severity on admission using National Institutes Health Scale (NIHSS)....
To investigate the prevalence of connective tissue abnormalities in patients with spontaneous cervical artery dissections (sCeAD).We systematically assessed clinically detectable signs aberration a series consecutive sCeAD and age- sex-matched ischemic stroke unrelated to CeAD (non-CeAD IS) by standard examination protocol including 68 items, performed extensive molecular investigation for hereditary disorders all sCeAD.The study group included 84 (mean age, 44.5 ± 7.8 years; 66.7% men)...
Lombardia GENS is a multicentre prospective study aimed at diagnosing 5 single-gene disorders associated with stroke (cerebral autosomal dominant arteriopathy subcortical infarcts and leukoencephalopathy, Fabry disease, MELAS [mitochondrial encephalomyopathy, lactic acidosis, stroke-like episodes], hereditary cerebral amyloid angiopathy, Marfan syndrome) by applying diagnostic algorithms specific for each clinically suspected diseaseWe enrolled consecutive series of patients ischemic or...
A 50-year-old women with Charcot-Marie-Tooth hereditary neuropathy type 1A due to the PMP22 duplication on chromosome 17p11.2-12 developed a left bundle branch block and progressive dilatation of ventricle since age 40 years recurrent heart failure 44 years. At 50 ventricular hypertrabeculation/noncompaction was first recognized transthoracic echocardiography. possible causal relation between cardiac abnormalities is discussed.
Background— We sought to compare the benefit of percutaneous closure that medical therapy alone for secondary prevention embolism in patients with patent foramen ovale (PFO) and otherwise unexplained ischemic stroke, a propensity scored study. Methods Results— Between 2000 2012, we selected consecutive first-ever stroke aged 18 45 years PFO no other cause brain ischemia, as part IPSYS registry (Italian Project on Stroke Young Adults), who underwent either or comparative analysis. Primary end...
Background and Purpose Migraine has been shown to increase cerebral excitability, promote rapid infarct expansion into tissue with perfusion deficits, result in larger infarcts animal models of focal ischemia. Whether these effects occur humans never properly investigated. Methods In a series consecutive patients acute ischemic stroke, enrolled the setting Italian Project on Stroke at Young Age, we assessed as well chronic volumes by volumetric magnetic resonance imaging, compared among...
Abstract We studied the localization of dystrophin in normal human fetal muscle by immunohistochemistry. Our results show appearance at week 11 and a progressive organization protein along membrane following weeks gestation. At 22 almost all fibers clear immunostaining. Concomitant analysis fiber‐type composition reveals no correlation between differentiation. findings suggest that synthesis developing skeletal is time‐related probably independent neuronal influences.