Valeria De Giuli
A5000274637- Acute Ischemic Stroke Management
- Intracerebral and Subarachnoid Hemorrhage Research
- Long-Term Effects of COVID-19
- Migraine and Headache Studies
- Building Energy and Comfort Optimization
- COVID-19 Clinical Research Studies
- Intracranial Aneurysms: Treatment and Complications
- Cerebrovascular and Carotid Artery Diseases
- Peripheral Neuropathies and Disorders
- Moyamoya disease diagnosis and treatment
- Infectious Encephalopathies and Encephalitis
- Cerebrovascular and genetic disorders
- Neurological Disorders and Treatments
- Neurological Complications and Syndromes
- Neurosurgical Procedures and Complications
- Educational Environments and Student Outcomes
- Systemic Lupus Erythematosus Research
- Urban Heat Island Mitigation
- Stroke Rehabilitation and Recovery
- SARS-CoV-2 and COVID-19 Research
- Alzheimer's disease research and treatments
- Cardiovascular Health and Disease Prevention
- Urban Green Space and Health
- Neuroinflammation and Neurodegeneration Mechanisms
- Diverse academic and cultural studies
Istituti Ospitalieri di Cremona
2020-2025
Azienda Socio Sanitaria Territoriale di Cremona
2020-2025
Misericordia University
2023
Centre Hospitalier Sainte-Anne
2021
University of Brescia
2014-2020
University of Pavia
2014-2018
Azienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia
2014-2018
IRCCS Istituto Auxologico Italiano
2016
University of Milano-Bicocca
2016
Azienda Ospedaliera Sant'Andrea
2014-2016
Abstract Background Recent findings indicated that severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-related neurological manifestations involve cytokine release along with endothelial activation, blood brain barrier dysfunction, and immune-mediated mechanisms. Very few studies have fully investigated the cerebrospinal fluid (CSF) correlates of SARS-CoV-2 encephalitis. Methods Patients polymerase chain reaction (PCR)-confirmed infection encephalitis (COV-Enc), without (ENC),...
Several preclinical and clinical investigations have argued for nervous system involvement in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Some sparse case reports described various forms of encephalitis disease 2019 (COVID-19) disease, but very few data focused on presentations, course, response to treatment, outcomes.The SARS-CoV-2 related encephalopaties (ENCOVID) multicenter study included patients with full infectious screening, cerebrospinal fluid (CSF),...
Background— Data on long-term risk and predictors of recurrent thrombotic events after ischemic stroke at a young age are limited. Methods Results— We followed 1867 patients with first-ever who were 18 to 45 years (mean age, 36.8±7.1 years; women, 49.0%), as part the Italian Project Stroke in Young Adults (IPSYS). Median follow-up was 40 months (25th 75th percentile, 53). The primary end point composite stroke, transient attack, myocardial infarction, or other arterial events. One hundred...
<h3>Background and Objective</h3> A variety of neurological disorders has been reported as presentations or complications COVID-19 infection. The objective this study was to determine their incidence dynamics long-term functional outcome. <h3>Methods</h3> Neuro-COVID Italy a multicentre, observational, cohort with ambispective recruitment prospective follow-up. Consecutive hospitalized patients presenting new associated infection (neuro-COVID), independently from respiratory severity, were...
Antibodies to proteolipid protein-1 (PLP1-IgG), a major central myelin protein also expressed in the peripheral nervous system (PNS) as isoform DM20, have been previously identified mostly patients with multiple sclerosis (MS), unclear clinical implications. However, most studies relied on nonconformational immunoassays and included few non-MS CNS autoimmune demyelinating disorders (ADDs). We aimed investigate conformational PLP1-IgG whole ADD spectrum. devised new live cell-based assay...
<h3>Importance</h3> Although sparse observational studies have suggested a link between migraine and cervical artery dissection (CEAD), any association the 2 disorders is still unconfirmed. This lack of definitive conclusion might implications in understanding pathogenesis both conditions complex relationship ischemic stroke (IS). <h3>Objective</h3> To investigate whether history its subtypes associated with occurrence CEAD. <h3>Design, Setting, Participants</h3> A prospective cohort study...
Recently, common genetic risk factors for intracranial aneurysm (IA) and aneurysmal subarachnoid hemorrhage (ASAH) were found to explain a large amount of disease heritability therefore have potential be used prediction. We constructed score (1) predict ASAH incidence IA presence (combined set unruptured ASAH) (2) assess its association with patient characteristics.
To investigate the prevalence of connective tissue abnormalities in patients with spontaneous cervical artery dissections (sCeAD).We systematically assessed clinically detectable signs aberration a series consecutive sCeAD and age- sex-matched ischemic stroke unrelated to CeAD (non-CeAD IS) by standard examination protocol including 68 items, performed extensive molecular investigation for hereditary disorders all sCeAD.The study group included 84 (mean age, 44.5 ± 7.8 years; 66.7% men)...
<h3>Objective</h3> Although a concern exists that 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors (statins) might increase the risk of intracerebral haemorrhage (ICH), contribution these agents to relationship between serum cholesterol and disease occurrence has been poorly investigated. <h3>Methods</h3> We compared consecutive patients having ICH with age sex-matched stroke-free control subjects in case–control analysis, as part Multicenter Study on Cerebral Haemorrhage Italy...
Introduction To describe clinical, neuroimaging, and laboratory features of a large cohort Italian patients with reversible cerebral vasoconstriction syndrome. Methods In the setting multicenter Project on Stroke at Young Age (IPSYS), we retrospectively enrolled diagnosis definite syndrome according to International Classification Headache Disorders (ICHD)-3 beta criteria (6.7.3 attributed syndrome, imaging-proven). Clinical manifestations, treatment, clinical outcomes were evaluated in all...
This study assesses the cerebrospinal fluid (CSF) levels of viral receptor angiotensin-converting enzyme 2 (ACE2) and serine protease TMPRSS2 fragments in patients with SARS-CoV-2 infection presenting encephalitis (CoV-Enceph). The included biobanked CSF from 18 CoV-Enceph, 4 subjects COVID-19 without (CoV), 21 non-COVID-related (Enceph), neurologically healthy controls. Participants underwent a standardized assessment for encephalitis. A large subset samples an extended panel neuronal,...
To test the hypothesis that effect of antithrombotic medications on risk intracerebral hemorrhage (ICH) varies according to location hematoma.Consecutive patients with ICH were enrolled as part Multicenter Study Cerebral Hemorrhage in Italy (MUCH-Italy). Multivariable logistic regression models served examine whether factors for and hematoma (deep vs lobar) predict treatment-specific subgroups (antiplatelets-related oral anticoagulants [OACs]-related ICH).A total 870 (313 lobar ICH, 557 deep...
Cerebral hyperexcitability in migraine experiencers might sensitize brain tissue to ischemia. We investigated whether a personal history of is associated with vulnerability ischemia humans.Multicenter cohort study patients acute ischemic stroke who underwent computed tomography perfusion and were scheduled undergo reperfusion therapy. In case-control design, we compared the proportion subjects no-mismatch, volume penumbra salvaged, as well final infarct size group no migraine.We included 61...
To assess putative risk factors and outcome of multiple early recurrent cervical artery dissection (CeAD). We combined data from 2 multicenter cohorts compared patients with CeAD at initial diagnosis, within 3 to 6 months, single nonrecurrent CeAD. Putative factors, clinical characteristics, functional outcome, ischemic events were assessed. Of 1,958 (mean ± SD age 44.3 10 years, 43.9% women), 1,588 (81.1%) had CeAD, 340 (17.4%) 30 (1.5%) presented admission Patients or did not significantly...
This study evaluates the indoor environmental conditions and children’s comfort levels in 8 classrooms three Italian primary schools. It is a development of pilot previously carried out by authors other educational buildings. Spot long-term measurements were made to evaluate microclimatic (i.e. air temperature, relative humidity, CO 2 concentration, illuminance). A questionnaire, distributed times, investigated students’ perception thermal lighting comfort, their satisfaction with...
Abstract Whether to resume antithrombotic treatment after oral anticoagulant–related intracerebral haemorrhage (OAC-ICH) is debatable. In this study, we aimed at investigating long-term outcome associated with OAC resumption warfarin-related ICH, in comparison secondary prevention strategies platelet inhibitors or discontinuation. Participants were patients who sustained an incident ICH during warfarin (2002–2014) included the Multicenter Study on Cerebral Hemorrhage Italy. Primary end-point...
<h3>Objective</h3> To investigate the role of alcohol as a causal factor for intracerebral hemorrhage (ICH) and whether its effects might vary according to pathogenic mechanisms underlying cerebral bleeding. <h3>Methods</h3> We performed case-control analysis, comparing cohort consecutive white patients with ICH aged 55 years older group age- sex-matched stroke-free controls, enrolled in setting Multicenter Study on Cerebral Haemorrhage Italy (MUCH-Italy) between 2002 2014. Participants were...
ABSTRACT Importance Several preclinical and clinical investigations have argued for nervous system involvement in SARS-CoV-2 infection. Some sparse case reports described various forms of encephalitis COVID-19 disease, but very few data focused on presentations, course, response to treatment outcomes yet. Objective describe the phenotype, laboratory neuroimaging findings associated with infection, their relationship respiratory function inflammatory parameters course treatment. Design The...