Agnese Novelli
A5000863018- Neurogenetic and Muscular Disorders Research
- RNA modifications and cancer
- Congenital Anomalies and Fetal Surgery
- Renal and related cancers
- Acute Ischemic Stroke Management
- Ion Transport and Channel Regulation
- Genomics and Rare Diseases
- RNA Interference and Gene Delivery
- RNA Research and Splicing
- Alzheimer's disease research and treatments
- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- Pluripotent Stem Cells Research
- Cerebrospinal fluid and hydrocephalus
- Intracerebral and Subarachnoid Hemorrhage Research
- Atrial Fibrillation Management and Outcomes
- Neurogenesis and neuroplasticity mechanisms
- Neurosurgical Procedures and Complications
- Cerebrovascular and Carotid Artery Diseases
- Extracellular vesicles in disease
Università Cattolica del Sacro Cuore
2021-2024
University of Perugia
2023
University of the Sacred Heart
2022
Pontifícia Universidade Católica de São Paulo
2022
Glioblastoma (GBM) stemlike cells (GSCs) are thought to be responsible for the maintenance and aggressiveness of GBM, most common primary brain tumor in adults. This study aims at elucidating involvement deregulations within imprinted delta-like homolog 1 gene‒type III iodothyronine deiodinase gene (DLK-DIO3) region on chromosome 14q32 GBM pathogenesis.Real-time PCR analyses were performed GSCs tissues. Methylation analyses, expression, reverse-phase protein array profiles used investigate...
Background Spinal muscular atrophy (SMA) is due to the homozygous absence of SMN1 in around 97% patients, independent severity (classically ranked into types I–III). The high genetic homogeneity, coupled with excellent results presymptomatic treatments patients each three disease-modifying therapies available, makes SMA one golden candidates newborn screening (NBS) (SMA-NBS). implementation NBS national programmes occurring some countries an arising new issue that scientific community has...
Spinal muscular atrophy (SMA) is a neuromuscular disorder characterized by the degeneration of second motor neuron. The phenotype ranges from very severe to mild forms. All patients have homozygous loss SMN1 gene and variable number SMN2 (generally 2-4 copies), inversely related severity. amazing results available treatments made compelling need prognostic biomarkers predict progression trajectories patients. Besides products, few other been evaluated so far, including some miRs.We performed...
Introduction: Patients with ischemic stroke (IS) and atrial fibrillation (AF) face a higher risk of recurrent vascular events. This study evaluates the impact atherosclerotic disease burden across different territories on events in patients recent AF within 90 days. Methods: We included IS from International RAF network prospective 90-day follow-up. Atherosclerotic was identified by at least one following: Symptomatic heart disease, symptomatic peripheral artery internal carotid stenosis...
Alzheimer's Disease (AD) is a neurodegenerative disorder characterized by the accumulation of pathological proteins and synaptic dysfunction. This study aims to investigate molecular functional differences between human induced pluripotent stem cells (hiPSCs) derived from patients with sporadic AD (sAD) age-matched controls (healthy subjects, HS), focusing on their neuronal differentiation properties in order better understand cellular mechanisms underlying pathology. Skin fibroblasts sAD (n...
Abstract Background and aims The effect of surgical treatment for spontaneous intracerebral hemorrhage (ICH) remains uncertain. We conducted an observational retrospective cohort study on supra-centimeter ICH treated with either neurosurgical or conservative management. baseline demographics risk factors were correlated in-hospital mortality 3 6-month survival rates stratified by Methods included all patients evidence > 1 cm detected CT admitted between august 2020 march 2021 to the “SMM”...