Agnese Novelli

ORCID: 0009-0008-4249-0841
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About
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Research Areas
  • Neurogenetic and Muscular Disorders Research
  • RNA modifications and cancer
  • Congenital Anomalies and Fetal Surgery
  • Renal and related cancers
  • Acute Ischemic Stroke Management
  • Ion Transport and Channel Regulation
  • Genomics and Rare Diseases
  • RNA Interference and Gene Delivery
  • RNA Research and Splicing
  • Alzheimer's disease research and treatments
  • MicroRNA in disease regulation
  • Cancer-related molecular mechanisms research
  • Pluripotent Stem Cells Research
  • Cerebrospinal fluid and hydrocephalus
  • Intracerebral and Subarachnoid Hemorrhage Research
  • Atrial Fibrillation Management and Outcomes
  • Neurogenesis and neuroplasticity mechanisms
  • Neurosurgical Procedures and Complications
  • Cerebrovascular and Carotid Artery Diseases
  • Extracellular vesicles in disease

Università Cattolica del Sacro Cuore
2021-2024

University of Perugia
2023

University of the Sacred Heart
2022

Pontifícia Universidade Católica de São Paulo
2022

Glioblastoma (GBM) stemlike cells (GSCs) are thought to be responsible for the maintenance and aggressiveness of GBM, most common primary brain tumor in adults. This study aims at elucidating involvement deregulations within imprinted delta-like homolog 1 gene‒type III iodothyronine deiodinase gene (DLK-DIO3) region on chromosome 14q32 GBM pathogenesis.Real-time PCR analyses were performed GSCs tissues. Methylation analyses, expression, reverse-phase protein array profiles used investigate...

10.1093/neuonc/noaa127 article EN cc-by-nc Neuro-Oncology 2020-05-21

Background Spinal muscular atrophy (SMA) is due to the homozygous absence of SMN1 in around 97% patients, independent severity (classically ranked into types I–III). The high genetic homogeneity, coupled with excellent results presymptomatic treatments patients each three disease-modifying therapies available, makes SMA one golden candidates newborn screening (NBS) (SMA-NBS). implementation NBS national programmes occurring some countries an arising new issue that scientific community has...

10.1136/jmg-2022-108873 article EN Journal of Medical Genetics 2022-11-22

Spinal muscular atrophy (SMA) is a neuromuscular disorder characterized by the degeneration of second motor neuron. The phenotype ranges from very severe to mild forms. All patients have homozygous loss SMN1 gene and variable number SMN2 (generally 2-4 copies), inversely related severity. amazing results available treatments made compelling need prognostic biomarkers predict progression trajectories patients. Besides products, few other been evaluated so far, including some miRs.We performed...

10.7554/elife.68054 article EN cc-by eLife 2021-09-20
Andrea Galeazzo Rigutini Andrea Galeazzo Rigutini Maurizio Paciaroni Virginia Cancelloni Gregory Y.H. Lip and 95 more Azmil H. Abdul‐Rahim Giancarlo Agnelli Cecilia Becattini Georgios Tsivgoulis David Seiffge Stefan T. Engelter Philippe Lyrer Alexandros A. Polymeris Tolga Dittrich Annaelle Zietz Gian Marco De Marchis Jukka Putaala Daniel Strbian Liisa Tomppo Patrik Michel Davide Strambo Alexander Salerno Peter Vanacker Susanna M. Zuurbier Laetitia Yperzeele Caroline M.J. Loos Manuel Cappellari Andrea Emiliani Marialuisa Zedde Rosario Pascarella Jesse Dawson Robert Cronshaw Erika Schirinzi Massimo Del Sette Christoph Stretz Narendra Kala Ashley Schomer Brian Mac Grory Mahesh Jayaraman Shadi Yaghi Karen L. Furie Luca Masotti Elisa Grifoni Danilo Toni Angela Risitano Anne Falcou Luca Petraglia Enrico Maria Lotti Lucia Pavolucci Piergiorgio Lochner Giorgio Silvestrelli Alfonso Ciccone Andrea Alberti Michele Venti Ilaria Leone De Magistris Maria Giulia Mosconi Michela Giustozzi Alessandro Bufi Agnese Novelli Odysseas Kargiotis Alessandro Rocco Marina Diomedi Simona Marcheselli Kateryna Antonenko Eugenia Rota Tiziana Tassinari Valentina Saia Francesco Palmerini Paolo Aridon Valentina Arnao Serena Monaco Salvatore Cottone Antonio Baldi Cataldo D’Amore Walter Ageno Samuela Pegoraro George Ntaios Anastasia Adamou Dimitrios Sagris Sotirios Giannopoulos Maria Kosmidou Evangelos Ntais Michele Romoli Leonardo Pantoni Sílvia Aguiar Rosa Pierluigi Bertora Alberto Chiti Isabella Canavero Carlo Emanuele Saggese M Plocco Elisa Giorli Lina Palaiodimou Eleni Bakola Fabio Bandini Antonio Gasparro Valeria Terruso Marina Mannino Alessandro Pezzini Raffaele Ornello Simona Sacco

Introduction: Patients with ischemic stroke (IS) and atrial fibrillation (AF) face a higher risk of recurrent vascular events. This study evaluates the impact atherosclerotic disease burden across different territories on events in patients recent AF within 90 days. Methods: We included IS from International RAF network prospective 90-day follow-up. Atherosclerotic was identified by at least one following: Symptomatic heart disease, symptomatic peripheral artery internal carotid stenosis...

10.1177/10760296241240746 article EN cc-by-nc Clinical and Applied Thrombosis/Hemostasis 2024-01-01

Alzheimer's Disease (AD) is a neurodegenerative disorder characterized by the accumulation of pathological proteins and synaptic dysfunction. This study aims to investigate molecular functional differences between human induced pluripotent stem cells (hiPSCs) derived from patients with sporadic AD (sAD) age-matched controls (healthy subjects, HS), focusing on their neuronal differentiation properties in order better understand cellular mechanisms underlying pathology. Skin fibroblasts sAD (n...

10.1186/s13195-024-01632-3 article EN cc-by-nc-nd Alzheimer s Research & Therapy 2024-12-19

Abstract Background and aims The effect of surgical treatment for spontaneous intracerebral hemorrhage (ICH) remains uncertain. We conducted an observational retrospective cohort study on supra-centimeter ICH treated with either neurosurgical or conservative management. baseline demographics risk factors were correlated in-hospital mortality 3 6-month survival rates stratified by Methods included all patients evidence > 1 cm detected CT admitted between august 2020 march 2021 to the “SMM”...

10.1007/s10072-023-07015-0 article EN cc-by Neurological Sciences 2023-08-14
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