A5067976716- Lung Cancer Treatments and Mutations
- Cancer Genomics and Diagnostics
- Lung Cancer Diagnosis and Treatment
- Lung Cancer Research Studies
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Esophageal Cancer Research and Treatment
- RNA modifications and cancer
- Colorectal Cancer Treatments and Studies
- Genetic factors in colorectal cancer
- Cancer-related gene regulation
- Ovarian cancer diagnosis and treatment
- Hepatocellular Carcinoma Treatment and Prognosis
- Ferroptosis and cancer prognosis
- Identification and Quantification in Food
- Genomics and Phylogenetic Studies
- Pancreatic and Hepatic Oncology Research
- Cancer Immunotherapy and Biomarkers
- HER2/EGFR in Cancer Research
- Brain Metastases and Treatment
- Cancer Mechanisms and Therapy
- Colorectal and Anal Carcinomas
- Endometrial and Cervical Cancer Treatments
- Cervical Cancer and HPV Research
- Lymphoma Diagnosis and Treatment
- Colorectal Cancer Surgical Treatments
Genesee Community College
2020-2025
Chinese Academy of Fishery Sciences
2015
Shanghai Ocean University
2015
This open-label phase II trial (NCT04542837) aimed to evaluate the efficacy and safety of KN046 combined with lenvatinib in patients advanced hepatocellular carcinoma (HCC), explore potential response biomarkers. Participants received 5 mg/kg every 3 weeks 12 or 8 mg once daily. The primary endpoints were safety, tolerability, dose-limiting toxicity (DLT), objective rate (ORR) according RECIST v1.1. A total fifty-five participants enrolled. results meet pre-specified endpoints. No DLT was...
Abstract Background The Mesenchymal epithelial transition factor ( MET ) gene encodes a receptor tyrosine kinase with pleiotropic functions in cancer. exon 14 skipping alterations and high-level amplification are oncogenic targetable genetic changes patients non-small-cell lung cancer (NSCLC). Resistance to inhibitors (TKIs) has been major challenge for targeted therapies that impairs their clinical efficacies. Methods Eighty-six NSCLC were categorized into three cohorts based on the time of...
ROS1 fusion-positive (ROS1+) nonsmall cell lung cancer (NSCLC) patients are highly sensitive to tyrosine kinase inhibitor (TKI) treatments. However, acquired TKI resistance remains the major hurdle preventing from experiencing prolonged benefits.
Background Defects in replication repair-associated DNA polymerases often manifest an ultra-high tumor mutational burden (TMB), which is associated with higher probabilities of response to immunotherapies. The functional and clinical implications different polymerase variants remain unclear. Methods Targeted next-generation sequencing using a 425-cancer gene panel, covers all exonic regions three genes ( POLE , POLD1 POLH ), was conducted cohort 12,266 patients across 16 types from January...
Abstract This study analyzed targeted sequencing data from 6530 tissue samples patients with metastatic Chinese colorectal cancer (CRC) to identify low mutation frequency and subgroup‐specific driver genes, using three algorithms for overall CRC as well across different clinicopathological subgroups. We 425 cancer‐related identifying 101 potential including 36 novel CRC. Notably, some genes demonstrated subgroup specificity; instance, ERBB4 was found a male‐specific gene mutations of only...
Ovarian cancer remains a global health challenge characterized by frequently delayed diagnosis and alarming mortality rates. Recent progress in the crosstalk between gut vaginal microbiomes ovarian provides new insights into complicated pathogenesis of cancer. Intestinal dysbiosis exerts significant in-fluence on occurrence development mainly through three principal pathways: estrogen metabolism potentiation, chronic inflammatory priming, DNA epigenetic reprogramming. research has provided...
Abstract The micropapillary (MIP) pattern is a high‐grade histological subtype of lung adenocarcinoma (LUAD) with poor prognosis. In this study, surgically resected tumor samples from 101 patients stage I–III MIP–LUAD (MIP ≥30%) were microdissected to separate MIP components non‐MIP components, all which underwent RNA and DNA whole‐exome sequencing (WES). genomic transcriptomic landscapes within MIP‐enriched tissues demonstrated remarkable similarities, notably marked by high epidermal...
Abstract Background: Age influences glioblastoma's molecular characteristics, with the 2021 WHO classification distinguishing pediatric and adult gliomas due to differing profiles prognoses, as glioblastomas show unique genetic alterations compared adults have a lower rate of malignant transformation. Although differences prognosis between pediatric-type adult-type glioblastoma are well-studied, impact age on patients remains underexplored. Methods: Targeted DNA sequencing data from baseline...
Abstract Background: The significant risk of tumor relapse in resectable non-small cell lung cancer (NSCLC) highlights the need for biomarkers to identify patients at increased recurrence and inform personalized treatment. Investigating potential plasma-derived circulating DNA (ctDNA) molecular residual disease (MRD) detection prognosis is essential, particularly context variations. Xuanwei, a city Yunnan province, China, provides valuable model exploring features related susceptibility....
Abstract Background: EGFR L833 and H835 mutations account for 0.5% of EGFR-mutated non-small cell lung cancer (NSCLC) cases are not classified as sensitive to tyrosine kinase inhibitors (TKIs) according NCCN guidelines, while chemotherapy remains the standard care patients with these mutations. Previous case reports have shown favorable EGFR-TKIs efficacy in mutations, this has yet be validated larger cohorts. Methods: DNA sequencing data from 240 NSCLC were analyzed, including 57 documented...
Abstract Background: Approximately 5% of female patients with colorectal cancer (CRC) develop ovarian metastasis (OM), predominantly in young women and leading to poorer survival. As the molecular mechanisms underlying OM remain unclear, this study aimed identify genetic determinants investigate synchronous metachronous metastasis. Methods: We retrospectively enrolled 81 CRC who had developed (28 matched primary metastatic lesion samples, 30 lesion, 23 samples). Treatment-naïve tissue...
Epidermal growth factor receptor (EGFR) exon 19 insertions (19ins) represent a unique subclass of alterations that has relatively low frequency. Here, we aimed to elucidate the molecular characteristics and response EGFR tyrosine kinase inhibitors (EGFR-TKIs) in lung cancer patients with 19ins. Next-generation sequencing was performed profile 83 non-small cell (NSCLC) Detailed profiling efficacy analyses were on these patients, comparisons 68 deletion (19del) patients. Potential resistance...
Abstract Background Pancreatic ductal adenocarcinoma (PDAC) is the major subtype of pancreatic cancer and head PDACs show distinct characteristics from body/tail PDACs. With limited studies based on Asian population, mutational landscape PDAC remains unclear. Methods One hundred fifty-one Chinese patients with were selected underwent targeted 425-gene sequencing. Genomic alterations, tumor burden, microsatellite instability analyzed compared a TCGA cohort. Results The genomic Western had...
Abstract The genomic origin and development of the biphasic lung adenosquamous carcinoma (ASC) remain inconclusive. Here, we derived potential evolutionary trajectory ASC through whole-exome sequencing, Stereo-seq, patient-derived xenografts. We showed that EGFR MET activating mutations were main drivers in ASCs. Phylogenetically, these passenger found both components trunk clonal events, confirming monoclonal origination. Comparison multiple lesions also revealed closer distance between...
Abstract Background Definitive chemoradiation therapy (dCRT) is the standard treatment for patients with nonsurgical esophageal squamous cell carcinoma (ESCC), yet have demonstrated great variations in their responses to dCRT and inevitably progressed following treatment. Methods To identify prognostic biomarkers, we performed targeted next‐generation sequencing of 416 cancer‐related genes on primary tumors from 47 ESCC prior The association between genetic alterations patients' local...
Common sensitizing mutations in epidermal growth factor receptor (cEGFR), including exon 19 deletions (19-Del) and 21 L858R substitution, are associated with high sensitivity to EGFR-TKIs NSCLC patients. The treatment for patients uncommon EGFR (uEGFR) remains a subject of debate due heterogeneity responses. In this manuscript, the targeted next-generation sequencing (NGS) data large cohort EGFR-mutated was assessed elucidate genomic profiles tumors carrying cEGFR or uEGFR mutations. results...
Chemo-radiotherapy (CRT) remains the main treatment modality for non-small-cell lung cancer (NSCLC). However, its clinical efficacy is largely limited by individual variations in radio-sensitivity and radiotherapy-associated toxicity. There an urgent need to identify genetic determinants that can explain patients' likelihood develop recurrence toxicity following CRT. In this study, we performed comprehensive genomic profiling, using a 474-cancer- radiotherapy-related gene panel, on...
Atypical L858R or other L858X mutations in the epidermal growth factor receptor (EGFR) gene, beyond classical EGFR
Next-generation sequencing (NGS) has enabled the detection of concomitant driver alterations in non-small cell lung cancer (NSCLC). However, magnitude and clinical relevance drivers remain to be explored.
Esophageal squamous cell carcinoma (ESCC) is the major type of EC in China. Chemoradiotherapy a standard definitive treatment for early-stage and significantly improves local control overall survival late-stage patients. However, chemoradiotherapy resistance, which limits therapeutic efficacy treatment-induced toxicity, still leading problem break. To optimize selection ESCC patients chemoradiotherapy, we retrospectively analyzed clinical features genome landscape Chinese cohort 58 TP53 was...
Molecular mechanisms behind potentially inferior prognosis of old cholangiocarcinoma (CCA) patients are unclear. Prevalence interventional targets and the difference between young CCA valuable for promising precision medicine. A total 188 with baseline tumor tissue samples were subgrouped into (≤45 years) (>45 sub-cohorts. Somatic germline mutation profiles, differentially enriched genetic alterations, actionable alterations compared. An external dataset was used validation molecular...