A5100758431- Gastric Cancer Management and Outcomes
- Metastasis and carcinoma case studies
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Esophageal Cancer Research and Treatment
- Gastrointestinal Tumor Research and Treatment
- Cancer Mechanisms and Therapy
- Ferroptosis and cancer prognosis
- Cancer-related molecular mechanisms research
- Cancer Immunotherapy and Biomarkers
- Hepatocellular Carcinoma Treatment and Prognosis
- Pancreatic and Hepatic Oncology Research
- Cancer Genomics and Diagnostics
- RNA modifications and cancer
- Inflammatory Biomarkers in Disease Prognosis
- Ovarian cancer diagnosis and treatment
- Radiomics and Machine Learning in Medical Imaging
- Monoclonal and Polyclonal Antibodies Research
- Drug Transport and Resistance Mechanisms
- Liver Disease Diagnosis and Treatment
- MicroRNA in disease regulation
- Helicobacter pylori-related gastroenterology studies
- Lung Cancer Treatments and Mutations
- Ubiquitin and proteasome pathways
- Cytokine Signaling Pathways and Interactions
- Cancer Research and Treatments
Zhejiang Cancer Hospital
2014-2025
Chinese Academy of Sciences
2020-2025
Hangzhou Cancer Hospital
2024-2025
University of Chinese Academy of Sciences
2020-2024
Cancer Hospital of Chinese Academy of Medical Sciences
2020-2024
Zhejiang Chinese Medical University
2015-2024
First Affiliated Hospital of Bengbu Medical College
2024
Nanfang Hospital
2011-2023
Southern Medical University
2011-2023
Henan Institute of Science and Technology
2023
Over-expression of long non-coding RNA HOTAIR has been reported in several types cancer. Yet its involvement gastric cancer (GC) not well understood. The aim present study was to examine the expression pattern GC patients, then, explore role promoting invasion and underlying molecular mechanism.The level tumor specimens patients quantified by Realtime RT-PCR. correlation between clinicopathological factors as prognosis then examined. Down-regulation interference applied investigate roles...
Metabolic biomarkers are expected to decode the phenotype of gastric cancer (GC) and lead high-performance blood tests towards GC diagnosis prognosis. We attempted develop diagnostic prognostic models for based on plasma metabolic information.We conducted a large-scale, multicentre study comprising 1944 participants from 7 centres in retrospective cohort 264 prospective cohort. Discovery verification phases were through machine learning Cox regression fingerprints (PMFs) obtained by...
Abstract Background Stomach and esophageal cancer exhibit high morbidity mortality rate in China, resulting substantial disease burdens. It is imperative to identify the temporal trends of stomach from 1990 2019 project future until 2030, which can provide valuable information for planning effective management prevention strategies. Methods We collected analysed data Global Burden Disease (GBD) between 2019, including incidence, mortality, disability-adjusted life years (DALYs),...
5-Fluorouracil (5Fu) chemotherapy is the first treatment of choice for advanced gastric cancer (GC), but its effectiveness limited by drug resistance. Emerging evidence suggests that existence stem cells (CSCs) contributes to chemoresistance. The aim present study was determine whether 5Fu generates residual with CSC-like properties in GC.Human GC cell lines, SGC7901 and AGS, were exposed increasing concentrations. assessed both chemosensitivity properties. B lymphoma Mo-MLV insertion region...
Gastric cancer (GC) is one of the most common malignant tumors in world.GPx4, as core regulator ferroptosis, has become a potential molecular target for developing anticancer agents.In present study, we found that GPx4 was overexpressed and negatively correlated with poor prognosis GC, while it associated GC development.Molecular docking structure-based virtual screening assays were used to screen inhibitors, identified novel inhibitor, polyphyllin B (PB), which can induce ferroptosis by...
Abstract The incidence of adenocarcinoma the esophagogastric junction (AEG) has been rapidly increasing in recent decades, but its molecular alterations and subtypes are still obscure. Here, we conduct proteomics phosphoproteomics profiling 103 AEG tumors with paired normal adjacent tissues (NATs), whole exome sequencing 94 tumor-NAT pairs, RNA 83 pairs. Our analysis reveals an extensively altered proteome 252 potential druggable proteins tumors. We identify three proteomic significant...
Abstract Gastric cancer (GC) presents a formidable global health challenge, and conventional therapies face efficacy limitations. Ubiquitin‐specific protease 7 (USP7) plays pivotal roles in GC development, immune response, chemo‐resistance, making it promising target. Various USP7 inhibitors have shown selectivity preclinical studies. However, the mechanistic role of has not been fully elucidated, currently, no approved for clinical use. In this study, DHPO is identified as potent inhibitor...
Abstract Early and accurate diagnosis of focal liver lesions is crucial for effective treatment prognosis. We developed validated a fully automated diagnostic system named Liver Artificial Intelligence Diagnosis System (LiAIDS) based on diverse sample 12,610 patients from 18 hospitals, both retrospectively prospectively. In this study, LiAIDS achieved an F1-score 0.940 benign 0.692 malignant lesions, outperforming junior radiologists (benign: 0.830-0.890, malignant: 0.230-0.360) being par...
Abstract Background Our previous study revealed marked differences in tongue images between individuals with gastric cancer and those without cancer. However, the biological mechanism of as a disease indicator remains unclear. Tongue coating, major factor appearance, is visible layer on dorsum that provides vital environment for oral microorganisms. While microorganisms are associated intestinal diseases, comprehensive function profiles microbiota remain incompletely understood....
Dual‑specificity phosphatase‑1 (DUSP1) is an oncogene that associated with cancer progression following drug resistance. In order to investigate the potential relationship between DUSP1 and apatinib resistance in gastric cells, we preformed many assays study this problem. gene was detected by RT‑qPCR assay, proteins MAPK pathway were quantified western blot CCK‑8 flow cytometry Hoechest 33342 stain performed detect of cell cycles apoptosis, respectively. Immunohistochemical staining used...