A5034472419- Cancer Genomics and Diagnostics
- Immune cells in cancer
- Ovarian cancer diagnosis and treatment
- Single-cell and spatial transcriptomics
- Immune Cell Function and Interaction
- CAR-T cell therapy research
- Acute Myeloid Leukemia Research
- Cancer Immunotherapy and Biomarkers
- Epigenetics and DNA Methylation
- Ferroptosis and cancer prognosis
- RNA modifications and cancer
- Immunotherapy and Immune Responses
- Bioinformatics and Genomic Networks
- Cancer-related molecular mechanisms research
- Protein Degradation and Inhibitors
- Peptidase Inhibition and Analysis
- Ubiquitin and proteasome pathways
- Cancer Cells and Metastasis
- Advanced Wireless Communication Techniques
- Lung Cancer Research Studies
- Lymphoma Diagnosis and Treatment
- Pancreatic and Hepatic Oncology Research
- Gene Regulatory Network Analysis
- T-cell and B-cell Immunology
- Error Correcting Code Techniques
Harbin Medical University
2013-2025
Jilin University
2022-2025
Affiliated Hospital of Qingdao University
2017-2025
Qingdao University
2008-2025
State Key Laboratory of Inorganic Synthesis and Preparative Chemistry
2022-2025
First Affiliated Hospital of Xi'an Jiaotong University
2020-2024
The University of Texas MD Anderson Cancer Center
2020-2024
Third Affiliated Hospital of Harbin Medical University
2024
Northwestern Polytechnical University
2017-2024
University of Macau
2015-2023
Accumulating evidence demonstrates that long non-coding RNAs (lncRNAs) play important roles in the development of complex human diseases. Predicting novel lncRNA–disease associations is a challenging and essential task.
Abstract Immune checkpoint therapy (ICT) provides substantial clinical benefits to cancer patients, but a large proportion of cancers do not respond ICT. To date, the genomic underpinnings primary resistance ICT remain elusive. Here, we performed immunogenomic analysis data from TCGA and trials anti-PD-1/PD-L1 therapy, with particular focus on homozygous deletion 9p21.3 (9p21 loss), one most frequent defects occurring in ~13% all cancers. We demonstrate that 9p21 loss confers “cold”...
Abstract Little is known of the geospatial architecture individual cell populations in lung adenocarcinoma (LUAD) evolution. Here, we perform single-cell RNA sequencing 186,916 cells from five early-stage LUADs and 14 multiregion normal tissues defined spatial proximities tumors. We show that cellular lineages, states, transcriptomic features geospatially evolve across regions to LUADs. also exhibit pronounced intratumor heterogeneity within single sites transcriptional lineage-plasticity...
Abstract Tumor-infiltrating B and plasma cells (TIB) are prevalent in lung adenocarcinoma (LUAD); however, they poorly characterized. We performed paired single-cell RNA B-cell receptor (BCR) sequencing of 16 early-stage LUADs 47 matching multiregion normal tissues. By integrative analysis ∼50,000 TIBs, we define 12 TIB subsets the LUAD adjacent ecosystems demonstrate extensive remodeling TIBs LUADs. Memory (PC) were highly enriched tumor tissues with more differentiated states increased...
Abstract Interferon gamma (IFNγ) is a critical cytokine known for its diverse roles in immune regulation, inflammation, and tumor surveillance. However, while IFNγ levels were elevated sera of most newly diagnosed acute myeloid leukemia (AML) patients, complex interplay AML remains insufficiently understood. We aim to characterize these interactions through comprehensive bulk single-cell approaches bone marrow patients. identify monocytic as having unique microenvironment characterized by...
Accumulated evidence has shown that long non-coding RNAs (lncRNA) act as a widespread layer in gene regulatory networks and are involved wide range of biological processes.
Accumulated evidence suggests that dysregulated expression of long non-coding RNAs (lncRNAs) may play a critical role in tumorigenesis and prognosis cancer, indicating the potential utility lncRNAs as cancer prognostic or diagnostic markers. However, power lncRNA signatures predicting survival patients with non-small cell lung (NSCLC) has not yet been investigated.We performed an array-based transcriptional analysis large patient cohorts NSCLC by repurposing microarray probes from gene...
Recent evidence shows that cyclic GMP-AMP synthase (cGAS)/stimulator of interferon (IFN) genes (STING) signaling is essential for antitumor immunity by inducing the production type I IFN and thus activating both innate adaptive based on gene knockout mouse models. However, extensive detection expression cGAS/STING in human cancer mining roles this pathway have not been performed until now. In study, we revealed four key molecules (cGAS, STING, TANK binding kinase 1 [TBK1], regulatory factor...
Cancer growth is usually accompanied by metastasis which kills most cancer patients. Here we aim to study the effect of cisplatin at different doses on breast and metastasis. Methods: We used treat cells, then detected migration cells changes epithelial-mesenchymal transition (EMT) markers assay, Western blot, immunofluorescent staining. Next, analyzed RNA expression genes RNA-seq confirmed binding activating transcription factor 3 (ATF3) cytoskeleton related ChIP-seq. Thereafter, combined...
Abstract In contrast to the curative effect of allogenic stem cell transplantation in acute myeloid leukemia via T activity, only modest responses are achieved with checkpoint-blockade therapy, which might be explained by phenotypes and receptor (TCR) repertoires. Here, we show paired single-cell RNA analysis TCR repertoire profiling bone marrow cells relapsed/refractory patients pre/post azacytidine+nivolumab treatment that disease-related subsets highly heterogeneous, their abundance...
Abstract Background Chimeric antigen receptor (CAR) T-cell therapy using brexucabtagene autoleucel (BA) induces remission in many patients with mantle cell lymphoma (MCL), and BA is the only CAR approved by FDA for MCL. However, development of relapses to recognized poor patient outcomes. Multiple therapies have been other lymphomas resistance mechanisms investigated. underlying relapse MCL not investigated whether any previously reported apply BA-relapsed unknown. Methods To interrogate...
The prototypic second messenger cyclic AMP (cAMP) is essential for controlling cellular metabolism, including glucose and lipid homeostasis.In mammals, the majority of cAMP functions are mediated by cAMP-dependent protein kinase (PKA) exchange proteins directly activated (Epacs).To explore physiological Epac1, we generated Epac1 knockout mice.Here report that null mutants have reduced white adipose tissue plasma leptin levels but display heightened sensitivity.Epac1-deficient mice more...
Tumor immune infiltrates of ovarian cancer were quite cohort and subtype dependent.
Purpose: Ovarian cancer is one of the first human cancers for which in situ immune response was reported to be important clinical outcome. To elucidate mechanistic relationship between repertoire and genotype ovarian cancer, development a well-defined score required.Experimental Design: From collection 2,203 patient samples advanced from public available resources, we evaluated prognostic values compendium marker genes proposed an score. The relationships score, tumor-infiltrating cells,...
Epigenetic therapy is a novel tumor therapeutic method and refers to the targeting of aberrant epigenetic modifications presumably at cancer-related genes by chemicals which are drugs (ETDs). Not like in treating hematopoietic cancer, clinical trials investigating potential use ETDs solid not encouraging. Instead, curative effects ETD delivered together with DNA chemo (DTDs) quite promising according our meta-analysis. To investigate synergistic mechanism DTD drug combination, effect was...
Venetoclax is effective in relapsed patients with mantle cell lymphoma (MCL). Mechanisms of resistance to venetoclax MCL are poorly understood. We describe the clinical outcomes and genomic characteristics 24 multiply (median five prior lines therapy) who received venetoclax-based therapies; 67% had progressed on BTK inhibitors (BTKi) 54% blastoid or pleomorphic histology. Median follow up after treatment was 17 months. The overall response rate 50% complete (CR) 21%, 16 15 died. median...
Clonal hematopoiesis is a prevalent age-related condition associated with greatly increased risk of hematologic disease; mutations in DNA methyltransferase 3A (DNMT3A) are the most common driver this state. DNMT3A variants occur across gene some particularly malignancy, but functional relevance and mechanisms pathogenesis majority unknown. Here, we systematically investigated activity protein stability 253 disease-associated mutations, found that 74% were loss-of-function mutations. Half...
Abstract The mechanisms driving therapeutic resistance and poor outcomes of mantle cell lymphoma (MCL) are incompletely understood. We characterize the cellular molecular heterogeneity within across patients delineate dynamic evolution tumor immune compartments at single resolution in longitudinal specimens from ibrutinib-sensitive non-responders. Temporal activation multiple cancer hallmark pathways acquisition 17q observed a refractory MCL. Multi-platform validation is performed genomic...