A5052221681- Acute Myeloid Leukemia Research
- CAR-T cell therapy research
- Chronic Myeloid Leukemia Treatments
- Immune cells in cancer
- Immune Cell Function and Interaction
- Single-cell and spatial transcriptomics
- Monoclonal and Polyclonal Antibodies Research
- Immunotherapy and Immune Responses
- Advanced biosensing and bioanalysis techniques
- Cancer Genomics and Diagnostics
- Advanced Biosensing Techniques and Applications
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Cancer Immunotherapy and Biomarkers
- Glycosylation and Glycoproteins Research
- Histone Deacetylase Inhibitors Research
- T-cell and B-cell Immunology
- Protein Degradation and Inhibitors
- Chronic Lymphocytic Leukemia Research
- Acute Lymphoblastic Leukemia research
- Hepatocellular Carcinoma Treatment and Prognosis
- Chemokine receptors and signaling
- Hematopoietic Stem Cell Transplantation
- Galectins and Cancer Biology
- Genomics and Rare Diseases
- PI3K/AKT/mTOR signaling in cancer
The University of Texas MD Anderson Cancer Center
2022-2025
The University of Texas at El Paso
2020-2024
Xi'an Jiaotong University
2024
Zhengzhou University
2019-2023
Leukemia Research Foundation
2022
China Three Gorges University
2022
Chinese Center For Disease Control and Prevention
2021
Weifang People's Hospital
2020
Chinese National Human Genome Center
2008
Chinese National Human Genome Center at Shanghai
2008
Abstract Interferon gamma (IFNγ) is a critical cytokine known for its diverse roles in immune regulation, inflammation, and tumor surveillance. However, while IFNγ levels were elevated sera of most newly diagnosed acute myeloid leukemia (AML) patients, complex interplay AML remains insufficiently understood. We aim to characterize these interactions through comprehensive bulk single-cell approaches bone marrow patients. identify monocytic as having unique microenvironment characterized by...
Background. Immune exhaustion and senescence are dominant dysfunctional states of effector T cells major hurdles for the success cancer immunotherapy. In current study, we characterized how acute myeloid leukemia (AML) promotes generation senescent-like CD8+ whether they have prognostic relevance.
Although the intention of 2016 US Centers for Disease Control and Prevention (CDC) Guideline Prescribing Opioids Chronic Pain was not to limit pain treatment patients with sickle cell disease (SCD), clinicians have recognized possibility that guideline may altered outcomes this population. However, patient population are unknown.
Abstract Purpose: Magrolimab is a monoclonal antibody directed against macrophage checkpoint CD47 on myeloid leukemia cells that was pre-clinically synergistic with azacitidine-venetoclax, warranting further clinical evaluation. Patients and Methods: In this phase 1b/2 study the triplet combination of azacitidine, venetoclax magrolimab evaluated in adult patients frontline (ineligible for intensive chemotherapy) relapsed/refractory AML. Azacitidine dosed at 75mg/m2 7 days, 400 mg/day 28...
Comprehensive investigation of CD8+ T cells in acute myeloid leukemia (AML) is essential for developing immunotherapeutic strategies beyond immune checkpoint blockade. Herein, we performed single-cell RNA profiling from 3 healthy bone marrow donors and 23 newly diagnosed (NewlyDx) 8 relapsed/refractory (RelRef) AML patients. Cells co-expressing canonical exhaustion markers formed a cluster constituting <1% all cells. We identified two effector cell subsets characterized by distinct cytokine...
Actinobacillus pleuropneumoniae is the etiologic agent of porcine contagious pleuropneumonia, a cause considerable world wide economic losses in swine industry. We sequenced complete genome A. pleuropneumoniae, JL03, an isolate serotype 3 prevalent China. Its single chromosome 2,242,062 base pairs containing 2,097 predicted protein-coding sequences, six ribosomal rRNA operons, and 63 tRNA genes. Preliminary analysis genomic sequence functions encoded proteins not only confirmed present...
Background Acute myeloid leukemia (AML) is associated with a dismal prognosis. Immune checkpoint blockade (ICB) to induce antitumor activity in AML patients has yielded mixed results. Despite the pivotal role of B cells immunity, comprehensive assessment lymphocytes within AML’s immunological microenvironment along their interaction ICB remains rather constrained. Methods We performed an extensive analysis that involved paired single-cell RNA and B-cell receptor (BCR) sequencing on 52 bone...
Nanoenabled strategies have recently attracted attention as a sustainable platform for agricultural applications. Here, we present mechanistic understanding of nanobiointeraction through an orthogonal investigation. Pristine (nS) and stearic acid surface-modified (cS) sulfur nanoparticles (NPs) multifunctional nanofertilizer were applied to tomato (Solanum lycopersicumL.) soil. Both nS cS increased root mass by 73% 81% shoot weight 35% 50%, respectively, compared the untreated controls. Bulk...
Monosomy 7 and 7q deletions (-7/del(7q)) are the most common adverse cytogenetic event in acute myeloid leukemia (AML), linked to high relapse rates. We analyzed 115 AML patients with -7/del(7q) who achieved remission after induction therapy characterize mutational landscape from diagnosis relapse. Median overall survival (OS) was 10.4 months, improved without TP53 mutation (13.04 vs. 8.6 months) or complex karyotype (12.4 months). mutations were frequent (67% of cases at diagnosis)...
The prognostic impact of cohesin mutations in patients with acute myeloid leukemia (AML) and myelodysplastic syndromes (MDS) is controversial. In AML MDS who underwent next-generation sequencing at the authors' center during 2017-2023, authors assessed landscape co-occurring on overall survival (OS) compared outcomes between those wild-type (WT) genes. study included 83 patients, 36 (STAG2, n = 28; SMC1A, 7; SMC3, 3; co-expression mutations, 2) 47 WT Of 17 (47%) had (six de novo 11...
Acute myeloid leukemia (AML) is a heterogeneous malignancy of the blood primarily treated with intensive chemotherapy. The allogeneic T-cell antileukemic activity via donor lymphocyte infusions and stem cell transplantation suggests potential role for checkpoint blockade therapy in AML. While clinical trials employing these treatments have fallen short expected results, deeper exploration into functional states T cells AML could bridge this knowledge gap. In study, we analyzed polyfunctional...
Cervical cancer is one of the most common female malignancies worldwide and represents a major global health challenge. The fast growth tumor high rates metastasis still lead to poor prognosis cervical patients. It urgent clarify mechanism identify predictive biomarkers for treatment cancer. Long non-coding RNAs (LncRNAs) have been identified in are related malignant phenotypes cells. However, roles LncRNA deleted lymphocytic leukemia (DLEU2) tumorigenesis progression remain unknown.qPCR was...
Background Serum autoantibodies (AAbs) against tumor-associated antigens (TAAs) could be useful biomarkers for cancer detection. This study aims to evaluate the diagnostic value of autoantibody PDLIM1 improving detection ovarian (OC). Methods Immunohistochemistry (IHC) test in tissue array containing 280 OC tissues, 20 adjacent and 8 normal tissues was performed analyze expression tissues. Enzyme-linked immunosorbent assay (ELISA) employed measure 545 sera samples from 182 patients with OC,...
Abstract Acute myeloid leukemia (AML) is a heterogeneous disease characterized by high rate of therapy resistance. Since the cell origin can impact response to therapy, it crucial understand lineage composition AML cells at time Here we leverage single-cell chromatin accessibility profiling 22 bone marrow aspirates from eight patients resistance and following subsequent characterize their landscape. Our findings reveal complex architecture therapy-resistant that are primed for stem...
Serum autoantibodies that react with tumor-associated antigens (TAAs) can be used as potential biomarkers for diagnosis of cancer. This study aims to evaluate the immunodiagnostic value 11 anti-TAAs detection breast cancer (BC) and establish a diagnostic model distinguishing BC from normal human controls (NHC) benign diseases (BBD). Sera 10 patients NHC were detect by western blotting. The further assessed in 983 sera relative quantitative enzyme-linked immunosorbent assay (ELISA). Binary...
Abstract Tumor‐associated autoantibodies (TAAb) could be serological tumor markers. This study aims to discover novel TAAb signatures for breast cancer (BC) detection. The protein microarray was used identify candidate TAAb, which were further validated in 1197 sera from BC, benign diseases (BD), and healthy controls (HC) by enzyme‐linked immunosorbent assay. In addition, 319 preoperative postoperative evaluated. A panel determined using four different classifiers. Twelve identified with...
Studies have demonstrated that autoantibodies to tumor-associated antigens (TAAs) may be used as efficient biomarkers with low-cost and highly sensitive characteristics. In this study, an enzyme-linked immunosorbent assay (ELISA) was conducted analyze paired box protein Pax-5 (PAX5), patched homolog 1 (PTCH1), guanine nucleotide-binding subunit alpha-11 (GNA11) in sera from Hispanic Americans including hepatocellular carcinoma (HCC) patients, patients liver cirrhosis (LC), chronic hepatitis...
<div>Abstract<p>Comprehensive investigation of CD8+ T cells in acute myeloid leukemia (AML) is essential for developing immunotherapeutic strategies beyond immune checkpoint blockade. Herein, we performed single-cell RNA profiling from 3 healthy bone marrow donors and 23 newly diagnosed (NewlyDx) 8 relapsed/refractory (RelRef) AML patients. Cells co-expressing canonical exhaustion markers formed a cluster constituting <1% all cells. We identified two effector cell subsets...
(1) Background: Autoantibodies to tumor-associated antigens (TAAs) have emerged as promising cancer biomarkers. Luminex technology offers a powerful approach for the simultaneous detection of multiple anti-TAA autoantibodies. (2) Methods: We aimed utilize evaluate and optimize panel anti-TAAs autoantibodies detecting prostate (PCa), which included fourteen TAAs. A total 163 serum samples (91 PCa, 72 normal controls) were screened determine levels using assay. (3) Results: Twelve exhibited...